Artículo
Abstract:
The effects of injecting estradiol, progesterone or both hormones, to immature rats,on the spontaneous contractions of isolated uterine horns and on prostaglandin (PG) E and F-like materials released into the bathing medium, were studied. The in vitro contractile decrement detected both in controls as well as in the group receiving progesterone (P4) alone, was only minor. On the other hand, preparations from rats treated with 17-beta-estradiol (E2) exhibited a significant and progressive reduction of spontaneous motility. Coincident with these smaller contractions a significant diminution of PGE-output accompanied by an enhancement of the release of PGF-like material into the suspending solution, were found. The initial (postisolation) isometric developed tension (IDT) of uterine preparations from immature rats injected with sex hormones was significantly higher than that of tissues from untreated control animals. Neither the initial contractile frequency (CF) nor its constancy changed following hormonal treatment (E2 Or P4),except in the case of uteri from animals administered with P4, which showed a smaller decrement of CF than controls. Furthermore, tissue preparations obtained from animals injected with P4 released into the bathing media similar amounts of PGE-like material as controls, but significantly more PGF. It is interesting that the injection of E2 Plus P4 increased the output of PGF-like material but did not modify that of PGE i. e., the depressive effect of estradiol on the release of PGE into the bathing media was abolished by the administration of P4. On the other hand, the addition of indomethacin or acetylsalicylic acid to the bath solution reduced significantly contractions of uterine horns isolated from immature animals. The foregoing results, supporting our previous findings on the effect of P4 on PGF release from the rat uterus, are in keeping with the hypothesis holding that better spontaneous motility correlates well with a greater release of PGE and that E2 injection coincides with a depression of both PGE output and myometrial contractions. © 1984.
Registro:
| Documento: | Artículo |
| Título: | Sex hormones and the motility of and prostaglandin output from, uterine horns of immature rats |
| Autor: | Chaud, M.; Gonzalez, E.T.; Franchi, A.M.; Gimeno, M.F.; Gimeno, A.L. |
| Filiación: | Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN). Serrano 665/669, 1414 Buenos Aires, Argentina Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET). Serr, 1414 Buenos Aires, Argentina |
| Palabras clave: | acetylsalicylic acid; estradiol; indometacin; progesterone; prostaglandin; age; animal experiment; drug efficacy; female genital system; immaturity; nonhuman; rat; uterus; Animals; Aspirin; Estradiol; Female; Indomethacin; Progesterone; Prostaglandins E; Prostaglandins F; Rats; Sexual Maturation; Uterine Contraction; Uterus; Animalia |
| Año: | 1984 |
| Volumen: | 15 |
| Número: | 1 |
| Página de inicio: | 35 |
| Página de fin: | 44 |
| DOI: | http://dx.doi.org/10.1016/0262-1746(84)90054-4 |
| Título revista: | Prostaglandins, Leukotrienes and Medicine |
| Título revista abreviado: | Prostaglandins Leukotrienes Med. |
| ISSN: | 02621746 |
| CODEN: | PLMED |
| CAS: | acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; estradiol, 50-28-2; indometacin, 53-86-1, 74252-25-8, 7681-54-1; progesterone, 57-83-0; Aspirin, 50-78-2; Estradiol, 50-28-2; Indomethacin, 53-86-1; Progesterone, 57-83-0; Prostaglandins E; Prostaglandins F |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02621746_v15_n1_p35_Chaud |
Referencias:
- Sterin-Speziale, Gimeno, Bonacossa, Gimeno, The effect of estradiol on isolated rat uterine motility and on prostaglandin generation (1980) Prostaglandins, 20, p. 233
- Franchi, Bonacossa, Gimeno, Gimeno, Effect of progesterone on the spontaneous motility and prostaglandin synthesis in uterine horns isolated from overiectomized rats (1982) Prostaglandins, 23, p. 819
- Franchi, Gonzalez, Gimeno, Gimeno, Progesterone enhances the output of prostaglandin F2-alpha by isolated uterine horns isolated from adult ovariectomized and immature rats (1982) Prostaglandins, 24, p. 775
- Gimeno, Borda, Lazzari, Gimeno, Ovarian hormones inhibit the release of prostacyclin like material from isolated rat uterus (1980) Prostaglandins, 20, p. 223
- Franchi, Chaud, Borda, Gimeno, Lazzari, Gimeno, Spontaneous motility and prostaglandin generation in rat uterine horns isolated during the es trous cycle (1981) Prostaglandins, 22, p. 637
- Meijs-Roelofs, de Greeff, Uilenbroek, Plasma progesterone and its relationship to serum gonadotrophins in immature female rats (1975) Journal of Endocrinology, 64, p. 329
- Meijs-Roelofs, Uilenbroek, de Jong, Welschen, Plasma oestradiol 17e and its relationship to serum follicle-stimulating hormone in immature female rats (1973) Journal of Endocrinology, 59, p. 295
- Gimeno, Borda, Sterin-Borda, Vidal, Gimeno, Pharmacologic influences on human ovarian contractions (1976) Obtet.Gynec. (N.Y.), 47, p. 218
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- Gilmore, Vane, Willie, Prostaglandins release by the spleen (1968) Nature, 218, p. 135
- Gimeno, Sterin-Speziale, Landa, Bonacossa, Gimeno, Is the spontaneous motility of isolated rat uterus controlled by prostaglandin E? (1979) Prostaglandins, 17, p. 673
- Ham, Cirillo, Zenetti, Kuehl, Estrogen directed synthesis of specific prostaglandins in uterus (1975) Proc. Natl. Acad. Sci.(U.S.A.), 72, p. 1420. , 3rd Ed
- Gimeno, Bedners, Goldraij, Gimeno, Studies on the contractile activity of myometrium isolated from overiectomized rats (1970) Acte physiol. latinoam., 20, p. 275
- Lima, Gimeno, Goldraij, Bedners, Gimeno, Prostaglandin F2 and motility of the myometrium isolated from overiectomized rats. Effects of 17-beta-es tradiol (1971) Life Science (Part I), 10, p. 999
- Vane, Williams, The contribution of prostaglandin production to contractions of the isolated uterus of the rat (1973) Brit. J. Pherm., 48, p. 629
- Landa, Sterin-Speziale, Bonscossa, Gimeno, Gimeno, Relationships between spontaneous or oxytocin induced motility and endogenous prostaglandins in two different regions of uterine horns isolated from rats in different periods of the estrus cycle (1977) Acts physiol. latinoem., 27, p. 391
- Gimeno, Borda, Peredo, Franchi, Lazzari, Gimeno, The spontaneous motility and the prostaglandin E-like material generation is different in the implantation and in the non-implantation regions of the uterus isolated from rats in natural estrus. Influences of indomethecin (1981) Pharmacol.Res.Comm., 13, p. 679
Citas:
---------- APA ----------
Chaud, M., Gonzalez, E.T., Franchi, A.M., Gimeno, M.F. & Gimeno, A.L. (1984) . Sex hormones and the motility of and prostaglandin output from, uterine horns of immature rats. Prostaglandins, Leukotrienes and Medicine, 15(1), 35-44.http://dx.doi.org/10.1016/0262-1746(84)90054-4
---------- CHICAGO ----------
Chaud, M., Gonzalez, E.T., Franchi, A.M., Gimeno, M.F., Gimeno, A.L. "Sex hormones and the motility of and prostaglandin output from, uterine horns of immature rats" . Prostaglandins, Leukotrienes and Medicine 15, no. 1 (1984) : 35-44.http://dx.doi.org/10.1016/0262-1746(84)90054-4
---------- MLA ----------
Chaud, M., Gonzalez, E.T., Franchi, A.M., Gimeno, M.F., Gimeno, A.L. "Sex hormones and the motility of and prostaglandin output from, uterine horns of immature rats" . Prostaglandins, Leukotrienes and Medicine, vol. 15, no. 1, 1984, pp. 35-44.http://dx.doi.org/10.1016/0262-1746(84)90054-4
---------- VANCOUVER ----------
Chaud, M., Gonzalez, E.T., Franchi, A.M., Gimeno, M.F., Gimeno, A.L. Sex hormones and the motility of and prostaglandin output from, uterine horns of immature rats. Prostaglandins Leukotrienes Med. 1984;15(1):35-44.http://dx.doi.org/10.1016/0262-1746(84)90054-4
