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Daniel Bonfil, R.; Medina, P.A.; Gómez, D.E.; Farias, E.; Lazarowski, A.; Gritti, M.F.L.; Meiss, R.P.; Bustuoabad, O.D. "Expression of gelatinise/type IV collagenase in tumor necrosis correlates with cell detachment and tumor invasion" (1992) Clinical & Experimental Metastasis. 10(3):211-220
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Abstract:

We have previously observed that acellular extracts from necrotic areas (NE) of the non-metastatic murine mammary adenocarcinoma M3, enhance in vitro cell detachment and spontaneous lung metastases. In the present study, using different proteinase inhibitors along with NE, only the calcium chelator EDTA could significantly abrogate the enhanced cell detachment from M3 produced by NE. The typical cleavage products of type IV collagenase were detected inside the tumor necrotic area, mainly in association with necrobiotic cells, as evaluated by Western blot analysis and immunohistochemical assays. Zymography revealed the presence of 72- and 92-kDa gelatinise/type IV collagenase in NE. Moreover, NE increased the in vitro invasive ability of cultured M3 cells. The use of specific antibodies against both 72- and 92-kDa type IV collagenases in the invasion assay showed that only the latter was able to revert the enhanced invasiveness to the baseline. It can be concluded that tumor necrosis is an important source of gelatinise/type IV collagenase, mainly in its 92 kDa form, and plays a major role in tumor invasion. © 1992 Rapid Communications of Oxford Ltd.

Registro:

Documento: Artículo
Título:Expression of gelatinise/type IV collagenase in tumor necrosis correlates with cell detachment and tumor invasion
Autor:Daniel Bonfil, R.; Medina, P.A.; Gómez, D.E.; Farias, E.; Lazarowski, A.; Gritti, M.F.L.; Meiss, R.P.; Bustuoabad, O.D.
Filiación:HHEMA, Academia Nacional de Medicina, Argentina
Fundación de Investigación del Cáncer, Argentina
Fundación de Investigación del Cáncer, F. D. Roosevelt 2408 1 'C', Buenos Aires, 1428, Argentina
Palabras clave:gelatinase; metalloproteinases; tumor invasion; tumor necrosis; type IV collagenase; antibody; collagenase; edetic acid; gelatinase; proteinase inhibitor; animal model; article; breast adenocarcinoma; cancer invasion; cell division; cell line; controlled study; enzyme activity; female; metastasis; mouse; nonhuman; tumor necrosis; Animal; Cell Adhesion; Collagen; Extracellular Matrix; Female; Gelatinases; Mice; Mice, Inbred BALB C; Microbial Collagenase; Necrosis; Neoplasm Invasiveness; Neoplasms, Experimental; Pepsin A; Protease Inhibitors; Support, Non-U.S. Gov't
Año:1992
Volumen:10
Número:3
Página de inicio:211
Página de fin:220
DOI: http://dx.doi.org/10.1007/BF00132753
Título revista:Clinical & Experimental Metastasis
Título revista abreviado:Clin Exp Metast
ISSN:02620898
CODEN:CEXMD
CAS:collagenase, 37288-86-1, 39433-96-0, 9001-12-1; edetic acid, 150-43-6, 60-00-4; gelatinase, 9040-48-6; proteinase inhibitor, 37205-61-1; Collagen, 9007-34-5; Gelatinases, EC 3.4.24.-; Microbial Collagenase, EC 3.4.24.3; Pepsin A, EC 3.4.23.1; Protease Inhibitors
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02620898_v10_n3_p211_DanielBonfil

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Citas:

---------- APA ----------
Daniel Bonfil, R., Medina, P.A., Gómez, D.E., Farias, E., Lazarowski, A., Gritti, M.F.L., Meiss, R.P.,..., Bustuoabad, O.D. (1992) . Expression of gelatinise/type IV collagenase in tumor necrosis correlates with cell detachment and tumor invasion. Clinical & Experimental Metastasis, 10(3), 211-220.
http://dx.doi.org/10.1007/BF00132753
---------- CHICAGO ----------
Daniel Bonfil, R., Medina, P.A., Gómez, D.E., Farias, E., Lazarowski, A., Gritti, M.F.L., et al. "Expression of gelatinise/type IV collagenase in tumor necrosis correlates with cell detachment and tumor invasion" . Clinical & Experimental Metastasis 10, no. 3 (1992) : 211-220.
http://dx.doi.org/10.1007/BF00132753
---------- MLA ----------
Daniel Bonfil, R., Medina, P.A., Gómez, D.E., Farias, E., Lazarowski, A., Gritti, M.F.L., et al. "Expression of gelatinise/type IV collagenase in tumor necrosis correlates with cell detachment and tumor invasion" . Clinical & Experimental Metastasis, vol. 10, no. 3, 1992, pp. 211-220.
http://dx.doi.org/10.1007/BF00132753
---------- VANCOUVER ----------
Daniel Bonfil, R., Medina, P.A., Gómez, D.E., Farias, E., Lazarowski, A., Gritti, M.F.L., et al. Expression of gelatinise/type IV collagenase in tumor necrosis correlates with cell detachment and tumor invasion. Clin Exp Metast. 1992;10(3):211-220.
http://dx.doi.org/10.1007/BF00132753