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Abstract:

Complexes of stoichiometries [M(oda)(4-pic)H 2 O]·xH 2 O [M = Cu(1), x = 2; Co (2), x = 4; Ni (3), x = 2; ] [Fe(oda)(4-pic)]·Cl (4) and {[Cu(2-pa) 2 ]·2H 2 O} n (5) (H 2 oda = oxydiacetic acid, 4-pic = 4-picoline and 2-paH = 2-picolinic acid) were prepared to explore their uses as possible models for mono- and poly-nuclear metallo-pharmaceuticals. The chemical structures were elucidated by IR, FAB-Mass, 1 H, 13 C NMR, EPR and UV-visible (ligand field) spectral analyses. Electrochemical investigations are consistent with formation of stable quasi-reversible redox Co II/III and Cu II/III couples in the solution. Single crystal X-ray data of the complex (5) indicated a 1D coordination polymeric structure with extensive H-bonding to form supramolecular frameworks. The antimicrobial activities were examined against Escherichia coli (k-12), Bacillus subtilis (MTC-121), Staphylococcus aureus (IOASA-22), Salmonella typhimurium (MTCC-98), Candida albicans, Aspergillus fumigatus and Penicillium marneffei. The superoxide dismutase (SOD) activities of the Cu(II) complexes (1 and 5) were assessed employing nitrobluetetrazolium (NBT) assay. © 2012 Elsevier Masson SAS. All rights reserved.

Registro:

Documento: Artículo
Título:Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure
Autor:Siddiqi, Z.A.; Sharma, P.K.; Shahid, M.; Khalid, M.; Anjuli; Siddique, A.; Kumar, S.
Filiación:Coordination Chemistry Research Group, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India
DQIAQF/INQUIMAE, Universidad de Buenos Aires, Ciudad Universitaria, Pab. II, p. 3, EHA1428 Buenos Aires, Argentina
Palabras clave:2-Picolinic acid; 4-Pcoline; Antimicrobial activities; Oxydiacetic acid; Superoxide dismutase (SOD) activity; Ternary complexes; cobalt complex; copper complex; iron complex; ligand; metal complex; nickel complex; oxydiacetic acid; picoline; picolinic acid; superoxide dismutase; transition element; unclassified drug; antibacterial activity; antifungal activity; antimicrobial activity; article; Aspergillus fumigatus; Bacillus subtilis; Candida albicans; carbon nuclear magnetic resonance; chemical structure; complex formation; crystal structure; cyclic potentiometry; electron spin resonance; enzyme activity; Escherichia coli; fast atom bombardment mass spectrometry; infrared spectroscopy; nonhuman; Penicillium marneffei; proton nuclear magnetic resonance; Salmonella typhimurium; Staphylococcus aureus; stoichiometry; structure analysis; supramolecular chemistry; ultraviolet spectroscopy; Acetates; Anti-Infective Agents; Bacteria; Coordination Complexes; Crystallography, X-Ray; Electrochemical Techniques; Fungi; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Metals, Heavy; Microbial Viability; Molecular Structure; Nitroblue Tetrazolium; Picolines; Picolinic Acids; Spectrophotometry, Infrared; Superoxide Dismutase; Superoxides
Año:2012
Volumen:57
Página de inicio:102
Página de fin:111
DOI: http://dx.doi.org/10.1016/j.ejmech.2012.08.043
Título revista:European Journal of Medicinal Chemistry
Título revista abreviado:Eur. J. Med. Chem.
ISSN:02235234
CODEN:EJMCA
CAS:picoline, 108-89-4, 109-06-8, 1333-41-1; picolinic acid, 3198-27-4, 98-98-6; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; Acetates; Anti-Infective Agents; Coordination Complexes; Metals, Heavy; Nitroblue Tetrazolium, 298-83-9; Picolines; Picolinic Acids; Superoxide Dismutase, 1.15.1.1; Superoxides, 11062-77-4; picolinic acid, QZV2W997JQ
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02235234_v57_n_p102_Siddiqi

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Citas:

---------- APA ----------
Siddiqi, Z.A., Sharma, P.K., Shahid, M., Khalid, M., Anjuli, Siddique, A. & Kumar, S. (2012) . Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure. European Journal of Medicinal Chemistry, 57, 102-111.
http://dx.doi.org/10.1016/j.ejmech.2012.08.043
---------- CHICAGO ----------
Siddiqi, Z.A., Sharma, P.K., Shahid, M., Khalid, M., Anjuli, Siddique, A., et al. "Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure" . European Journal of Medicinal Chemistry 57 (2012) : 102-111.
http://dx.doi.org/10.1016/j.ejmech.2012.08.043
---------- MLA ----------
Siddiqi, Z.A., Sharma, P.K., Shahid, M., Khalid, M., Anjuli, Siddique, A., et al. "Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure" . European Journal of Medicinal Chemistry, vol. 57, 2012, pp. 102-111.
http://dx.doi.org/10.1016/j.ejmech.2012.08.043
---------- VANCOUVER ----------
Siddiqi, Z.A., Sharma, P.K., Shahid, M., Khalid, M., Anjuli, Siddique, A., et al. Superoxide scavenging and antimicrobial activities of novel transition metal complexes of oxydiacetate dianion as primary ligand: Spectral characterization, cyclic voltammetric investigations and crystal structure. Eur. J. Med. Chem. 2012;57:102-111.
http://dx.doi.org/10.1016/j.ejmech.2012.08.043