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Abstract:

Introduction: Epidemiological studies have demonstrated that patients with diabetes mellitus have an increased risk of developing Alzheimer disease, but the relationship between the 2 entities is not clear. Development: Both diseases exhibit similar metabolic abnormalities: disordered glucose metabolism, abnormal insulin receptor signalling and insulin resistance, oxidative stress, and structural abnormalities in proteins and β-amyloid deposits. Different hypotheses have emerged from experimental work in the last two decades. One of the most comprehensive relates the microvascular damage in diabetic polyneuritis with the central nervous system changes occurring in Alzheimer disease. Another hypothesis considers that cognitive impairment in both diabetes and Alzheimer disease is linked to a state of systemic oxidative stress. Recently, attenuation of cognitive impairment and normalisation of values in biochemical markers for oxidative stress were found in patients with Alzheimer disease and concomitant diabetes. Antidiabetic drugs may have a beneficial effect on glycolysis and its end products, and on other metabolic alterations. Conclusions: Diabetic patients are at increased risk for developing Alzheimer disease, but paradoxically, their biochemical alterations and cognitive impairment are less pronounced than in groups of dementia patients without diabetes. A deeper understanding of interactions between the pathogenic processes of both entities may lead to new therapeutic strategies that would slow or halt the progression of impairment. © 2013 Sociedad Española de Neurología.

Registro:

Documento: Artículo
Título:Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis
Autor:Domínguez, R.O.; Pagano, M.A.; Marschoff, E.R.; González, S.E.; Repetto, M.G.; Serra, J.A.
Filiación:Departamento de Neurología, Hospital Sirio Libanés, Facultad de Medicina Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
Departamento de Neurología, Hospital Juan A. Fernández, Facultad de Medicina Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Bioquímica y Medicina Molecular (IBIMOL UBA-CONICET), Facultad de Farmacia y Bioquímica Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina
Palabras clave:Alzheimer's disease; Cerebral glucose metabolism; Diabetes mellitus type 2; Hypoglycaemic drugs; Insulin resistance; Oxidative stress; amyloid beta protein; insulin receptor; Alzheimer disease; cognitive defect; diabetic neuropathy; glucose metabolism; human; insulin resistance; microangiopathy; non insulin dependent diabetes mellitus; oxidative stress; protein defect; Short Survey; Alzheimer disease; Cognition Disorders; complication; dementia; disease course; metabolism; non insulin dependent diabetes mellitus; Alzheimer Disease; Cognition Disorders; Dementia; Diabetes Mellitus, Type 2; Disease Progression; Humans; Oxidative Stress
Año:2014
Volumen:29
Número:9
Página de inicio:567
Página de fin:572
DOI: http://dx.doi.org/10.1016/j.nrl.2013.05.006
Título revista:Neurologia
Título revista abreviado:Neurologia
ISSN:02134853
CODEN:NERLE
CAS:amyloid beta protein, 109770-29-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02134853_v29_n9_p567_Dominguez

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Citas:

---------- APA ----------
Domínguez, R.O., Pagano, M.A., Marschoff, E.R., González, S.E., Repetto, M.G. & Serra, J.A. (2014) . Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis . Neurologia, 29(9), 567-572.
http://dx.doi.org/10.1016/j.nrl.2013.05.006
---------- CHICAGO ----------
Domínguez, R.O., Pagano, M.A., Marschoff, E.R., González, S.E., Repetto, M.G., Serra, J.A. "Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis " . Neurologia 29, no. 9 (2014) : 567-572.
http://dx.doi.org/10.1016/j.nrl.2013.05.006
---------- MLA ----------
Domínguez, R.O., Pagano, M.A., Marschoff, E.R., González, S.E., Repetto, M.G., Serra, J.A. "Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis " . Neurologia, vol. 29, no. 9, 2014, pp. 567-572.
http://dx.doi.org/10.1016/j.nrl.2013.05.006
---------- VANCOUVER ----------
Domínguez, R.O., Pagano, M.A., Marschoff, E.R., González, S.E., Repetto, M.G., Serra, J.A. Alzheimer disease and cognitive impairment associated with diabetes mellitus type 2: Associations and a hypothesis . Neurologia. 2014;29(9):567-572.
http://dx.doi.org/10.1016/j.nrl.2013.05.006