Artículo

Elola, M.T.; Ferragut, F.; Cárdenas Delgado, V.M.; Nugnes, L.G.; Gentilini, L.; Laderach, D.; Troncoso, M.F.; Compagno, D.; Wolfenstein-Todel, C.; Rabinovich, G.A. "Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors" (2014) Histology and Histopathology. 29(9):1093-1105
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Abstract:

Galectin-8 (Gal-8) is a 'tandem-repeat'-type galectin, which possesses two carbohydrate recognition domains connected by a linker peptide. Gal-8 complexity is related to the alternative splicing of its mRNA precursor, which is known to generate isoforms. Regarding its carbohydrate-binding specificity, Gal-8 has a unique feature among galectins, since its C-terminal domain has higher affinity for N-glycan-type branched oligosaccharides, while its N-terminal domain shows strong affinity for α2-3-sialylated or 3'-sulfated ß-galactosides. We integrate here the available information on Gal-8 expression in different tumor types and attempt to elucidate associations of its expression and localization during tumor progression with the overarching goal of analyzing its potential applications in diagnosis and prognosis. Differential diagnosis is still a prime concern in tumor pathology, and Gal-8 could be of great value in some types of primary or secondary tumors (i.e. papillary thyroid carcinoma, advanced colon carcinoma from patients with distant metastases, or metastases from primary lung carcinoma). The prognostic value of Gal-8 has been described for laryngeal carcinoma as well as advanced colon carcinoma. Further studies are needed to explain the relevance of Gal-8 and its isoforms in tumor pathology and their different intra- or extracellular roles (cytoplasmic, nuclear or extracellular) in tumor biology.

Registro:

Documento: Artículo
Título:Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors
Autor:Elola, M.T.; Ferragut, F.; Cárdenas Delgado, V.M.; Nugnes, L.G.; Gentilini, L.; Laderach, D.; Troncoso, M.F.; Compagno, D.; Wolfenstein-Todel, C.; Rabinovich, G.A.
Filiación:Institute of Biochemistry and Biophysics (IQUIFIB), UBA-CONICET, Department of Biological Chemistry, School of Pharmacy and Biochemistry. University of Buenos Aires, Argentina
Laboratory of Functional Glycomics, IQUIBICEN, CONICET, Department of Biological Chemistry, School of Exact and Natural Sciences, University of Buenos Aires, Argentina
Laboratory of Immunopathology, Institute of Experimental Biology and Medicine (IBYME), NICET, Buenos Aires, Argentina
Palabras clave:Galectin-8; Isoforms; Lung; Prostate; Tumors; galectin; LGALS8 protein, human; tumor marker; human; metabolism; neoplasm; pathology; Galectins; Humans; Neoplasms; Tumor Markers, Biological
Año:2014
Volumen:29
Número:9
Página de inicio:1093
Página de fin:1105
Título revista:Histology and Histopathology
Título revista abreviado:Histol. Histopathol.
ISSN:02133911
CODEN:HIHIE
CAS:Galectins; LGALS8 protein, human; Tumor Markers, Biological
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02133911_v29_n9_p1093_Elola

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Citas:

---------- APA ----------
Elola, M.T., Ferragut, F., Cárdenas Delgado, V.M., Nugnes, L.G., Gentilini, L., Laderach, D., Troncoso, M.F.,..., Rabinovich, G.A. (2014) . Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors. Histology and Histopathology, 29(9), 1093-1105.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02133911_v29_n9_p1093_Elola [ ]
---------- CHICAGO ----------
Elola, M.T., Ferragut, F., Cárdenas Delgado, V.M., Nugnes, L.G., Gentilini, L., Laderach, D., et al. "Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors" . Histology and Histopathology 29, no. 9 (2014) : 1093-1105.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02133911_v29_n9_p1093_Elola [ ]
---------- MLA ----------
Elola, M.T., Ferragut, F., Cárdenas Delgado, V.M., Nugnes, L.G., Gentilini, L., Laderach, D., et al. "Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors" . Histology and Histopathology, vol. 29, no. 9, 2014, pp. 1093-1105.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02133911_v29_n9_p1093_Elola [ ]
---------- VANCOUVER ----------
Elola, M.T., Ferragut, F., Cárdenas Delgado, V.M., Nugnes, L.G., Gentilini, L., Laderach, D., et al. Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors. Histol. Histopathol. 2014;29(9):1093-1105.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02133911_v29_n9_p1093_Elola [ ]