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Abstract:

Objectives: To study the interrelationship between serum Interleukin-6 (IL-6), serum Interleukin-6 soluble Receptor (IL-6 sR), C-Reactive Protein (C-RP), plasmatic Zinc levels (PlZn) and their response in relation to Zn administered by TPN, in critical patients. Methods: 17 patients, receiving TPN as a consequence of acute pancreatitis (n = 4) or after a major abdominal surgery due to intestinal cancer (n = 7), intestinal fístula (n = 3), intestinal obstruction (n = 2) or intestinal íleus (n = 1) were studied. At the beginning (To) and at the end of the TPN administration (6-21days) serum IL-6 and IL-6 sR were determined by ELISA; C-RP ultrasensitive (C-RP us) by inmunoturbidimetric method; Zn was determined in TPN and in plasma by Atomic Absorption Spectrometry. Characteristics of the patients were (mean ± SD and ranges): age: 60.6 ± 11.7 (37-77) years; BMI (kg/m2): 26.0 ± 3.4 (19.9-34.0). Results: The results (mean ± standard deviation and ranges) were: Zn provided by TPN (mg/d): 6.1 ± 2.0 (range 2.8 to 10.8). Biochemical levels were, at To and Tf, respectively: (mean±SD and ranges) were at To y Tf, respectively: Zn Pl (?g/dl): 104 ± 46 (35-177); 120 ± 55 (52-229); IL-6 (pg/mL) 93 ± 74 (10-262); 117 ± 180 (7-761); IL6sR (pg/mL): 1,012 ± 322 (589-1855); 1,269 ± 451 (631-2195); C-RP us (mg/L): 71 ± 63 (2-196); 65 ± 43 (0-137). There was no correlation between variations of IL6, IL6sR, C-RP, PlZn levels and the daily amount of Zn administered in the TPN mixtures. Two patients presented a bad evolution; they received 4.2 and 5.2 md/d of Zn and showed an increase of IL6 levels, maintained high levels of IL6sR but C-RP levels decreased Conclusions: the range of 2.8 to 10.8 mg/d of Zn administered in TPN mixtures did not exacerbate the inflammatory response.

Registro:

Documento: Artículo
Título:Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients
Autor:Menéndez, A.Ma.; De Portela, Ma.L.P.M.; Weisstaub, A.; Montemerlo, H.; Guidoni, Ma.E.; Rusí, F.; Zeni, S.
Filiación:Cátedra de Nutrición, Facultad de Farmacia Y Bioquímica, UBA, Junin 956, 2 p., 1113 Buenos Aires, Argentina
Instituto Argentino de Educación e Investigación en Nutrición, Buenos Aires, Argentina
Cátedra de Farmacia Hospitalaria Y Clínica, Facultad de Ciencias Exactas Y Naturales, Universidad de Belgrano, Buenos Aires, Argentina
CONICET (Consejo Nacional de Investigaciones Científicas Y Técnicas), Argentina
Idioma: Español
Palabras clave:Critically ill patients with parenteral nutrition; Interleukin-6; Soluble receptor of interleukin-6, and C reactive protein; Zinc; C reactive protein; interleukin 6; interleukin 6 receptor; zinc; abdominal surgery; acute pancreatitis; adult; aged; article; clinical article; critically ill patient; diet supplementation; enzyme linked immunosorbent assay; female; human; ileus; inflammation; intestine cancer; intestine fistula; male; total parenteral nutrition; Adult; Aged; C-Reactive Protein; Critical Illness; Female; Humans; Interleukin-6; Male; Middle Aged; Parenteral Nutrition, Total; Receptors, Interleukin-6; Zinc; Fistula
Año:2009
Volumen:24
Número:3
Página de inicio:340
Página de fin:346
Título revista:Nutricion Hospitalaria
Título revista abreviado:Nutr. Hosp.
ISSN:02121611
CODEN:NUHOE
CAS:C reactive protein, 9007-41-4; zinc, 7440-66-6; C-Reactive Protein, 9007-41-4; Interleukin-6; Receptors, Interleukin-6; Zinc, 7440-66-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02121611_v24_n3_p340_Menendez

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Citas:

---------- APA ----------
Menéndez, A.Ma., De Portela, Ma.L.P.M., Weisstaub, A., Montemerlo, H., Guidoni, Ma.E., Rusí, F. & Zeni, S. (2009) . Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients . Nutricion Hospitalaria, 24(3), 340-346.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02121611_v24_n3_p340_Menendez [ ]
---------- CHICAGO ----------
Menéndez, A.Ma., De Portela, Ma.L.P.M., Weisstaub, A., Montemerlo, H., Guidoni, Ma.E., Rusí, F., et al. "Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients " . Nutricion Hospitalaria 24, no. 3 (2009) : 340-346.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02121611_v24_n3_p340_Menendez [ ]
---------- MLA ----------
Menéndez, A.Ma., De Portela, Ma.L.P.M., Weisstaub, A., Montemerlo, H., Guidoni, Ma.E., Rusí, F., et al. "Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients " . Nutricion Hospitalaria, vol. 24, no. 3, 2009, pp. 340-346.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02121611_v24_n3_p340_Menendez [ ]
---------- VANCOUVER ----------
Menéndez, A.Ma., De Portela, Ma.L.P.M., Weisstaub, A., Montemerlo, H., Guidoni, Ma.E., Rusí, F., et al. Influence of zinc administered by total parenteral nutrition on plasmatic zinc levels, on reactive C protein, on serum interleukin-6 and on serum interleukin-6 soluble receptor, in critical patients . Nutr. Hosp. 2009;24(3):340-346.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02121611_v24_n3_p340_Menendez [ ]