Artículo

Costas, M.A.; Mella, D.; Criscuolo, M.; Díaz, A.; Finkielman, S.; Nahmod, V.E.; Arzt, E. "Superinduction of Mitogen-Stimulated Interferon-γ Production and Other Lymphokines by Sendai Virus" (1993) Journal of Interferon Research. 13(6):407-412
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Abstract:

We observed that Sendai virus preinduction of peripheral blood mononuclear cells and subsequent mitogenic stimulation resulted in: (i) Superproduction of interferon-γ, (IFN-γ) (ii) an increase in interleukin-2 (IL-2) synthesis that correlates with DNA synthesis when stimulated with phytohemagglutinin (PHA) or pokeweed mitogen (PWM) after treatment with the Sendai virus, while stimulation with Protein A from Staphylococcus aureus was not affected, and (iii) enhanced tumor necrosis factor-α (TNF-α) production in response to bacterial lipopolyssacharide (LPS). Treatment of monocyte cultures with LPS and cycloheximide or actinomycin-D inhibited the superinduction phenomenon. When cycloheximide was added at the viral induction time, the inhibition of TNF-α superproduction and DNA synthesis was still observed. These results suggest that Sendai virus lymphocyte superinduction is specific for a particular stimulatory pathway, not dependent on mRNA accumulation, and probably mediated by induction of an activating protein. © 1993, Mary Ann Liebert, Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Superinduction of Mitogen-Stimulated Interferon-γ Production and Other Lymphokines by Sendai Virus
Autor:Costas, M.A.; Mella, D.; Criscuolo, M.; Díaz, A.; Finkielman, S.; Nahmod, V.E.; Arzt, E.
Filiación:Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET, 1033 Buenos Aires, Argentina
Biosidus S.A., 1254 Buenos Aires, Argentina
Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Buenos Aires, 1427 Buenos Aires, Argentina
Departamento de Biología, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Palabras clave:bacterium lipopolysaccharide; gamma interferon; interleukin 2; lymphokine; mitogenic agent; phytohemagglutinin; pokeweed mitogen; protein a; tumor necrosis factor alpha; article; cell stimulation; dna synthesis; gene expression; genetic transcription; human; human cell; immune response; interferon production; mononuclear cell; priority journal; sendai virus; virus induction; virus inhibition; CD4-CD8 Ratio; Cells, Cultured; Cycloheximide; Dactinomycin; DNA; Human; Interferon Inducers; Interferon Type II; Interleukin-2; Lymphokines; Mitogens; Parainfluenza Virus 1, Human; Proteins; Tumor Necrosis Factor; Viral Proteins
Año:1993
Volumen:13
Número:6
Página de inicio:407
Página de fin:412
DOI: http://dx.doi.org/10.1089/jir.1993.13.407
Título revista:Journal of Interferon Research
Título revista abreviado:J. Interferon Res.
ISSN:01978357
CAS:gamma interferon, 82115-62-6; interleukin 2, 85898-30-2; phytohemagglutinin, 9008-97-3; pokeweed mitogen, 63231-57-2; Cycloheximide, 66-81-9; Dactinomycin, 50-76-0; DNA, 9007-49-2; Interferon Inducers; Interferon Type II, 82115-62-6; Interleukin-2; Lymphokines; Mitogens; Proteins; Tumor Necrosis Factor; Viral Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01978357_v13_n6_p407_Costas

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Citas:

---------- APA ----------
Costas, M.A., Mella, D., Criscuolo, M., Díaz, A., Finkielman, S., Nahmod, V.E. & Arzt, E. (1993) . Superinduction of Mitogen-Stimulated Interferon-γ Production and Other Lymphokines by Sendai Virus. Journal of Interferon Research, 13(6), 407-412.
http://dx.doi.org/10.1089/jir.1993.13.407
---------- CHICAGO ----------
Costas, M.A., Mella, D., Criscuolo, M., Díaz, A., Finkielman, S., Nahmod, V.E., et al. "Superinduction of Mitogen-Stimulated Interferon-γ Production and Other Lymphokines by Sendai Virus" . Journal of Interferon Research 13, no. 6 (1993) : 407-412.
http://dx.doi.org/10.1089/jir.1993.13.407
---------- MLA ----------
Costas, M.A., Mella, D., Criscuolo, M., Díaz, A., Finkielman, S., Nahmod, V.E., et al. "Superinduction of Mitogen-Stimulated Interferon-γ Production and Other Lymphokines by Sendai Virus" . Journal of Interferon Research, vol. 13, no. 6, 1993, pp. 407-412.
http://dx.doi.org/10.1089/jir.1993.13.407
---------- VANCOUVER ----------
Costas, M.A., Mella, D., Criscuolo, M., Díaz, A., Finkielman, S., Nahmod, V.E., et al. Superinduction of Mitogen-Stimulated Interferon-γ Production and Other Lymphokines by Sendai Virus. J. Interferon Res. 1993;13(6):407-412.
http://dx.doi.org/10.1089/jir.1993.13.407