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Abstract:

Pinealectomy of rats resulted in significant depression of benzodiazepine receptors (assessed by [3H]flunitrazepam binding) in cerebral cortex 3-14 days after surgery without affecting their affinity significantly. A single s.c. injection of melatonin (800 μg/kg body wt) restored the depressed brain benzodiazepine receptor sites. Single melatonin injections (up to 1600 μg/kg) to intact rats did not affect brain benzodiazepine binding when injected at either morning or evening hours. Daily melatonin treatment to intact rats for 5 days augmented benzodiazepine receptor density in brain (morning injections) or its dissociation constant (evening injections). Melatonin added in vitro to rat cerebral cortex membranes only slightly depressed [3H]flunitrazepam binding at 100 μM concentrations. These results point out a link between pineal activity and benzodiazepine receptor function in rats. They also indicate that pharmacological doses of melatonin affect benzodiazepine binding sites in rat cerebral cortex. © 1985.

Registro:

Documento: Artículo
Título:Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex
Autor:Lowenstein, P.R.; Rosenstein, R.; Cardinali, D.P.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Serrano 665, 1414 Buenos Aires, Argentina
Palabras clave:4' chlorodiazepam; benzodiazepine; clonazepam; flumazenil; flunitrazepam; melatonin; radioisotope; animal cell; animal experiment; biological model; brain cortex; central nervous system; dose response; dose time effect relation; drug comparison; drug interaction; drug mechanism; drug receptor binding; drug response; endocrine system; flunitrazepam h 3; nonhuman; pharmacokinetics; priority journal; rat; subcutaneous drug administration
Año:1985
Volumen:7
Número:4
Página de inicio:675
Página de fin:681
DOI: http://dx.doi.org/10.1016/0197-0186(85)90065-8
Título revista:Neurochemistry International
Título revista abreviado:Neurochem. Int.
ISSN:01970186
CODEN:NEUID
CAS:4' chlorodiazepam, 14439-61-3; benzodiazepine, 12794-10-4; clonazepam, 1622-61-3; flumazenil, 78755-81-4; flunitrazepam, 1622-62-4; melatonin, 73-31-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01970186_v7_n4_p675_Lowenstein

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Citas:

---------- APA ----------
Lowenstein, P.R., Rosenstein, R. & Cardinali, D.P. (1985) . Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex. Neurochemistry International, 7(4), 675-681.
http://dx.doi.org/10.1016/0197-0186(85)90065-8
---------- CHICAGO ----------
Lowenstein, P.R., Rosenstein, R., Cardinali, D.P. "Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex" . Neurochemistry International 7, no. 4 (1985) : 675-681.
http://dx.doi.org/10.1016/0197-0186(85)90065-8
---------- MLA ----------
Lowenstein, P.R., Rosenstein, R., Cardinali, D.P. "Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex" . Neurochemistry International, vol. 7, no. 4, 1985, pp. 675-681.
http://dx.doi.org/10.1016/0197-0186(85)90065-8
---------- VANCOUVER ----------
Lowenstein, P.R., Rosenstein, R., Cardinali, D.P. Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex. Neurochem. Int. 1985;7(4):675-681.
http://dx.doi.org/10.1016/0197-0186(85)90065-8