Artículo

Sáenz, D.A.; Bari, S.E.; Salido, E.; Chianelli, M.; Rosenstein, R.E. "Effect of nitroxyl on the hamster retinal nitridergic pathway" (2007) Neurochemistry International. 51(6-7):424-432
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Abstract:

There is a growing body of evidence on the role of nitric oxide (NO) in retinal physiology. Recently, interest has developed in the functional role of an alternative redox form of NO, namely nitroxyl (HNO/NO-), because it is formed by a number of diverse biochemical reactions. The aim of the present report was to comparatively analyze the effect of HNO and NO on the retinal nitridergic pathway in the golden hamster. For this purpose, sodium trioxodinitrate (Angeli's salt) and diethylammonium (Z)-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DEA/NO) were used as HNO and NO releasers, respectively. Angeli's salt and DEA/NO significantly decreased nitric oxide synthase activity. In addition, Angeli's salt (but not DEA/NO) significantly decreased l-arginine uptake. DEA/NO significantly increased cGMP accumulation at low micromolar concentrations, while Angeli's salt affected this parameter with a threshold concentration of 200 μM. Although Angeli's salt and DEA/NO significantly diminished reduced glutathione and protein thiol levels in a similar way, DEA/NO was significantly more effective than AS in increasing S-nitrosothiol levels. None of these compounds increased retinal lipid peroxidation. These results suggest that HNO could regulate the hamster retinal nitridergic pathway by acting through a mechanism that only partly overlaps with that involved in NO response. © 2007 Elsevier Ltd. All rights reserved.

Registro:

Documento: Artículo
Título:Effect of nitroxyl on the hamster retinal nitridergic pathway
Autor:Sáenz, D.A.; Bari, S.E.; Salido, E.; Chianelli, M.; Rosenstein, R.E.
Filiación:Laboratorio de Neuroquímica Retiniana y Oftalmología Experimental, Departamento de Bioquímica Humana, Facultad de Medicina, Buenos Aires, Argentina
Departamento de Química Inorgánica, Analítica y Química Física/INQUIMAE, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina
Palabras clave:Nitric oxide; Nitroxyl; Retina; amine; ammonium derivative; arginine; cyclic GMP; diethylammonium 1 (n,n diethylamino)diazen 1 ium 1,2 diolate; glutathione; nitric acid derivative; nitric oxide; nitric oxide synthase; nitroxyl; s nitrosothiol; sodium derivative; sodium trioxodinitrate; thiol; unclassified drug; animal cell; animal tissue; article; comparative study; concentration (parameters); controlled study; enzyme activity; lipid peroxidation; male; nonhuman; oxidation reduction potential; priority journal; regulatory mechanism; retina nerve cell; Syrian hamster; Animals; Antioxidants; Arginine; Cricetinae; Cyclic GMP; Dose-Response Relationship, Drug; Glutathione; Lipid Peroxidation; Male; Mesocricetus; Nitrergic Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitrogen Oxides; Oxidative Stress; Quaternary Ammonium Compounds; Retina; S-Nitrosothiols; Signal Transduction; Visual Pathways; Cricetinae; Mesocricetus auratus
Año:2007
Volumen:51
Número:6-7
Página de inicio:424
Página de fin:432
DOI: http://dx.doi.org/10.1016/j.neuint.2007.04.015
Título revista:Neurochemistry International
Título revista abreviado:Neurochem. Int.
ISSN:01970186
CODEN:NEUID
CAS:arginine, 1119-34-2, 15595-35-4, 7004-12-8, 74-79-3; cyclic GMP, 7665-99-8; glutathione, 70-18-8; nitric oxide, 10102-43-9; nitric oxide synthase, 125978-95-2; Antioxidants; Arginine, 74-79-3; Cyclic GMP, 7665-99-8; Glutathione, 70-18-8; Nitric Oxide, 10102-43-9; Nitric Oxide Synthase, 1.14.13.39; Nitrites; Nitrogen Oxides; Quaternary Ammonium Compounds; S-Nitrosothiols; diethylammonium-1-(N,N-diethylamino)diazen-1-ium-1,2-diolate; nitroxyl, 14332-28-6; oxyhyponitrite, 18550-55-5
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01970186_v51_n6-7_p424_Saenz

Referencias:

  • Adak, S., Wang, Q., Stuehr, D.J., Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase: implications for mechanism (2000) J. Biol. Chem., 275, pp. 33554-33561
  • Ahmad, I., Leinders-Zufall, T., Kocsis, J.D., Shepherd, G.M., Zufall, F., Barnstable, C.J., Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors (1994) Neuron, 12, pp. 155-165
  • Arnelle, D.R., Stamler, J.S., NO+, NO, and NO- donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation (1995) Arch. Biochem. Biophys., 318, pp. 279-285
  • Bae, S.Y., Xu, Q., Hutchinson, D., Colton, C.A., Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase (2005) Biochim. Biophys. Acta, 1745, pp. 65-73
  • Bari, S.E., Martí, M., Amorebieta, V., Estrin, D.A., Doctorovich, F., Fast nitroxyl trapping by ferric porphyrins (2003) J. Am. Chem. Soc., 125, pp. 15272-15273
  • Bazylinski, D.A., Hollocher, T.C., Metmyoglobin and methemoglobin as efficient traps for nitrosyl hydride (nitroxyl) in neutral aqueous solution (1985) J. Am. Chem. Soc., 107, pp. 7982-7986
  • Bermejo, E., Sáenz, D.A., Alberto, F., Rosenstein, R.E., Bari, S.E., Lazzari, M.A., Effect of nitroxyl on human platelets function (2005) Thromb. Haemost., 94, pp. 578-584
  • Beutler, E., Duron, O., Kelly, B.M., Improved method for the determination of blood glutathione (1963) J. Lab. Clin. Med., 61, pp. 882-888
  • Block, E.R., Herrera, H., Couch, M., Hypoxia inhibits l-arginine uptake by pulmonary artery endothelial cells (1995) Am. J. Physiol., 269, pp. L574-L580
  • Blough, N.V., Zafiriou, D.C., Reaction of superoxide with nitric oxide to form peroxynitrite in alkaline solution (1985) Inorg. Chem., 24, pp. 3504-3505
  • Bonner, F.T., Ravid, B., Thermal decomposition of oxyhyponitrite (sodium trioxodinitrate II) in aqueous solution (1975) Inorg. Chem., 14, pp. 558-563
  • Costa, G., Labadia, A., Triguero, D., Jimenez, E., Garcia-Pascual, A., Nitrergic relaxation in urethral smooth muscle: involvement of potassium channels and alternative redox forms of NO (2001) Naunyn Schmiedebergs Arch. Pharmacol., 364, pp. 516-523
  • Cudeiro, J., Rivadulla, C., Sight and insight-on the physiological role of nitric oxide in the visual system (1999) Trends Neurosci., 22, pp. 109-116
  • Dalle-Donne, I., Giustarini, D., Colombo, R., Milzani, A., Rossi, R., S-glutathionylation in human platelets by a thiol-disulfide exchange-independent mechanism (2005) Free Radic. Biol. Med., 38, pp. 1501-1510
  • Dawson, T.M., Steiner, J.P., Dawson, V.L., Dinerman, J.L., Uhl, G.R., Snyder, S.H., Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity (1993) Proc. Natl. Acad. Sci. U.S.A., 90, pp. 9808-9812
  • Devés, R., Boyd, C.A., Transporters for cationic amino acids in animal cells: discovery, structure, and function (1998) Physiol. Rev., 78, pp. 487-545
  • Dierks, E.A., Burstyn, J.N., Nitric oxide (NO), the only nitrogen monoxide redox form capable of activating soluble guanylyl cyclase (1996) Biochem. Pharmacol., 51, pp. 1593-1600
  • Du, Y., Smith, M.A., Miller, C.M., Kern, T.S., Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine (2002) J. Neurochem., 80, pp. 771-779
  • Erwin, P.A., Lin, A.J., Golan, D.E., Michel, T., Receptor-regulated dynamic S-nitrosylation of endothelial nitric-oxide synthase in vascular endothelial cells (2005) J. Biol. Chem., 280, pp. 18894-19888
  • Espey, M.G., Miranda, K.M., Thomas, D.D., Wink, D.A., Ingress and reactive chemistry of nitroxyl-derived species within human cells (2002) Free Radic. Biol. Med., 33, pp. 827-834
  • Feelisch, M., Nitroxyl gets to the heart of the matter (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 4978-4980
  • Fukuto, J.M., Chiang, K., Hszieh, R., Wong, P., Chaudhuri, G., The pharmacological activity of nitroxyl: a potent vasodilator with activity similar to nitric oxide and/or endothelium-derived relaxing factor (1992) J. Pharmacol. Exp. Ther., 263, pp. 546-551
  • Griscavage, J.M., Fukuto, J.M., Komori, Y., Ignarro, L.J., Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide (1994) J. Biol. Chem., 269, pp. 21644-21649
  • Hess, D.T., Matsumoto, A., Kim, S.O., Marshall, H.E., Stamler, J.S., Protein S-nitrosylation: purview and parameters (2005) Natl. Rev. Mol. Cell. Biol., 6, pp. 150-166
  • Hofmann, H., Schmidt, H.H., Thiol dependence of nitric oxide synthase (1995) Biochemistry, 34, pp. 13443-13452
  • Hughes, M.N., Cammack, R., Synthesis, chemistry, and applications of nitroxyl ion releasers sodium trioxodinitrate or Angeli's salt and Piloty's acid (1999) Meth. Enzymol., 301, pp. 279-287
  • Kotsonis, P., Frey, A., Frohlich, L.G., Hofmann, H., Reif, A., Wink, D.A., Feelisch, M., Schmidt, H.H., Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity (1999) Biochem. J., 340, pp. 745-752
  • Kurenny, D.E., Moroz, L.L., Turner, R.W., Sharkey, K.A., Barnes, S., Modulation of ion channels in rod photoreceptors by nitric oxide (1994) Neuron, 13, pp. 315-324
  • Kurz, S., Harrison, D., Insulin and the arginine paradox (1997) J. Clin. Invest., 99, pp. 369-370
  • Llomovatte, D.W., Lacoste, F.F., Zotter, C., Sarmiento, M.I., Rosenstein, R.E., Photic control of nitric oxide synthase activity in golden hamster retina (1997) Neuroreport, 8, pp. 3763-3766
  • Lopez, B.E., Shinyashiki, M., Han, T.H., Fukuto, J.M., Antioxidant actions of nitroxyl (HNO) (2007) Free Radic. Biol. Med., 42, pp. 482-491
  • Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent (1951) J. Biol. Chem., 193, pp. 265-275
  • Maragos, C.M., Morley, D., Wink, D.A., Dunams, T.M., Saavedra, J.E., Hoffman, A., Bove, A.A., Keefer, L.K., Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects (1991) J. Med. Chem., 34, pp. 3242-3247
  • Martinez-Ruiz, A., Lamas, S., S-nitrosylation: a potential new paradigm in signal transduction (2004) Cardiovasc. Res., 62, pp. 43-52
  • Mc Donald, K., Zharikov, S., Block, E., Kilberg, M., A caveolar complex between the cationic amino acid transporter 1 andendothelial nitric-oxide synthase may explain the "arginine paradox" (1997) J. Biol Chem., 272, pp. 31213-31216
  • Michel, T., Li, G.K., Busconi, L., Phosphorylation and subcellular translocation of endothelial nitric oxide synthase (1993) Proc. Natl. Acad. Sci. U.S.A., 90, pp. 6252-6256
  • Miranda, K.M., Espey, M.G., Yamada, K., Krishna, M., Ludwick, N., Kim, S., Jourd'heuil, D., Wink, D.A., Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion (2001) J. Biol. Chem., 276, pp. 1720-1727
  • Miranda, K.M., Nims, R.W., Thomas, D.D., Espey, M.G., Citrin, D., Bartberger, M.D., Paolocci, N., Wink, D.A., Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS (2003) J. Inorg. Biochem., 93, pp. 52-60
  • Miranda, K.M., Paolocci, N., Katori, T., Thomas, D.D., Ford, E., Bartberger, M.D., Espey, M.G., Wink, D.A., A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 9196-9201
  • Miranda, K.M., Dutton, A.S., Ridnour, L.A., Foreman, C.A., Ford, E., Paolocci, N., Katori, T., Wink, D.A., Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH (2005) J. Am. Chem. Soc., 127, pp. 722-731
  • Mitchell, D.A., Erwin, P.A., Michel, T., Marletta, M.A., S-Nitrosation and regulation of inducible nitric oxide synthase (2005) Biochemistry, 44, pp. 4636-4647
  • Nawy, S., Jahr, C.E., Suppression by glutamate of cGMP-activated conductance in retinal bipolar cells (1990) Nature, 346, pp. 269-271
  • Noll, G.N., Billek, M., Pietruck, C., Schmidt, K.F., Inhibition of nitric oxide synthase alters light responses and dark voltage of amphibian photoreceptors (1994) Neuropharmacology, 33, pp. 1407-1412
  • O'Brien, D.F., The chemistry of vision (1982) Science, 218, pp. 961-966
  • Osborne, N.N., Wood, J.P., Metipranolol blunts nitric oxide-induced lipid peroxidation and death of retinal photoreceptors: a comparison with other anti-glaucoma drugs (2004) Invest. Ophthalmol. Vis. Sci., 45, pp. 3787-3795
  • Paolocci, N., Katori, T., Champion, H.C., St John, M.E., Miranda, K.M., Fukuto, J.M., Wink, D.A., Kass, D.A., Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling (2003) Proc. Natl. Acad. Sci. U.S.A., 100, pp. 5537-5542
  • Peyrot, F., Fernandez, B.O., Bryan, N.S., Feelisch, M., Ducrocq, C., N-Nitroso products from the reaction of indoles with Angeli's salt (2006) Chem. Res. Toxicol., 19, pp. 58-67
  • Rogers, N.E., Ignarro, L.J., Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from l-arginine (1992) Biochem. Biophys. Res. Commun., 189, pp. 242-249
  • Sacca, G.B., Sáenz, D.A., Jaliffa, C.O., Minces, L., Keller Sarmiento, M.I., Rosenstein, R.E., Photic regulation of heme oxygenase activity in the golden hamster retina: involvement of dopamine (2003) J. Neurochem., 85, pp. 534-542
  • Sáenz, D.A., Cymeryng, C.B., De Nichilo, A., Sacca, G.B., Keller Sarmiento, M.I., Rosenstein, R.E., Photic regulation of l-arginine uptake in the golden hamster retina (2002) J. Neurochem., 80, pp. 512-519
  • Schmidt, H.H., Hofmann, H., Schindler, U., Shutenko, Z.S., Cunningham, D.D., Feelisch, M., NO from NO synthase (1996) Proc. Natl. Acad. Sci. U.S.A., 93, pp. 14492-14497
  • Sessa, W.C., The nitric oxide synthase family of proteins (1994) J. Vasc. Res., 31, pp. 131-143
  • Stamler, J.S., Lamas, S., Fang, F.C., Nitrosylation. The prototypic redox-based signalling mechanism (2001) Cell, 106, pp. 675-683
  • Vaananen, A.J., Moed, M., Tuominen, R.K., Helkamaa, T.H., Wiksten, M., Liesi, P., Chiueh, C.C., Rauhala, P., Angeli's salt induces neurotoxicity in dopaminergic neurons in vivo and in vitro (2003) Free Radic. Res., 37, pp. 381-389
  • Vanuffelen, B.E., Van Der Zee, J., De Koster, B.M., Vansteveninck, J., Elferink, J.G., Intracellular but not extracellular conversion of nitroxyl anion into nitric oxide leads to stimulation of human neutrophil migration (1998) Biochem. J., 330, pp. 719-722
  • Wink, D.A., Mitchell, J.B., Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide (1998) Free Radic. Biol. Med., 25, pp. 434-456
  • Wink, D.A., Kim, S., Coffin, D., Cook, J.C., Vodovotz, Y., Chistodoulou, D., Jourd'heuil, D., Grisham, M.B., Detection of S-nitrosothiols by fluorometric and colorimetric methods (1999) Meth. Enzymol., 301, pp. 201-211
  • Wink, D.A., Vodovotz, Y., Grisham, M.B., DeGraff, W., Cook, J.C., Pacelli, R., Krishna, M., Mitchell, J.B., Antioxidant effects of nitric oxide (1999) Meth. Enzymol., 301, pp. 413-424
  • Wink, D.A., Miranda, K.M., Katori, T., Mancardi, D., Thomas, D.D., Ridnour, L., Espey, M.G., Paolocci, N., Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm (2003) Am. J. Physiol.: Heart. Circ. Physiol., 285, pp. 2264-2276
  • Wong, P.S., Hyun, J., Fukuto, J.M., Shirota, F.N., DeMaster, E.G., Shoeman, D.W., Nagasawa, H.T., Reaction between S-nitrosothiols and thiols: generation of nitroxyl (HNO) and subsequent chemistry (1998) Biochemistry, 37, pp. 5362-5371
  • Xia, Y., Zweier, J.L., Direct measurement of nitric oxide generation from nitric oxide synthase (1997) Proc. Natl. Acad. Sci. U.S.A., 94, pp. 12705-12710

Citas:

---------- APA ----------
Sáenz, D.A., Bari, S.E., Salido, E., Chianelli, M. & Rosenstein, R.E. (2007) . Effect of nitroxyl on the hamster retinal nitridergic pathway. Neurochemistry International, 51(6-7), 424-432.
http://dx.doi.org/10.1016/j.neuint.2007.04.015
---------- CHICAGO ----------
Sáenz, D.A., Bari, S.E., Salido, E., Chianelli, M., Rosenstein, R.E. "Effect of nitroxyl on the hamster retinal nitridergic pathway" . Neurochemistry International 51, no. 6-7 (2007) : 424-432.
http://dx.doi.org/10.1016/j.neuint.2007.04.015
---------- MLA ----------
Sáenz, D.A., Bari, S.E., Salido, E., Chianelli, M., Rosenstein, R.E. "Effect of nitroxyl on the hamster retinal nitridergic pathway" . Neurochemistry International, vol. 51, no. 6-7, 2007, pp. 424-432.
http://dx.doi.org/10.1016/j.neuint.2007.04.015
---------- VANCOUVER ----------
Sáenz, D.A., Bari, S.E., Salido, E., Chianelli, M., Rosenstein, R.E. Effect of nitroxyl on the hamster retinal nitridergic pathway. Neurochem. Int. 2007;51(6-7):424-432.
http://dx.doi.org/10.1016/j.neuint.2007.04.015