Artículo

Suarez, C.; Díaz-Torga, G.; González-Iglesias, A.; Cristina, C.; Becu-Villalobos, D. "Upregulation of angiotensin II type 2 receptor expression in estrogen-induced pituitary hyperplasia" (2004) American Journal of Physiology - Endocrinology and Metabolism. 286(5 49-5):E786-E794
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Abstract:

Recent evidence shows that reexpression and upregulation of angiotensin II (ANG II) type 2 (AT2) receptor in adult tissues occur during pathological conditions such as tissue hyperplasia, inflammation, and remodeling. In particular, expression of functional AT2 receptors in the pituitary and their physiological significance and regulation have not been described. In this study, we demonstrate that chronic in vivo estrogen treatment, which induces pituitary hyperplasia, enhances local AT2 expression (measured by Western blot and RT-PCR) concomitantly with downregulation of ANG II type 1 (AT1) receptors. In vivo progesterone treatment of estrogen-induced pituitary hyperplasia did not modify either the ANG II receptor subtype expression pattern or octapeptide-induced and AT1-mediated calcium signaling. Nevertheless, an unexpected potentiation of the ANG II prolactin-releasing effect was observed in this group, and this response was sensitive to both AT1 and AT2 receptor antagonists. These data are the first to document that ANG II can act at the pituitary level through the AT2 receptor subtype and that estrogens display a differential regulation of AT1 and AT2 receptors at this level.

Registro:

Documento: Artículo
Título:Upregulation of angiotensin II type 2 receptor expression in estrogen-induced pituitary hyperplasia
Autor:Suarez, C.; Díaz-Torga, G.; González-Iglesias, A.; Cristina, C.; Becu-Villalobos, D.
Filiación:Inst. de Biología y Med. Exp., Consejo Nac. de Invest. Cie. y Tec., 1428 Buenos Aires, Argentina
Inst. de Biología y Med. Exp., CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Calcium signaling; Prolactin; Reverse transcriptase-polymerase chain reaction; Western blot; angiotensin 1 receptor antagonist; angiotensin 2 receptor; angiotensin 2 receptor antagonist; diethylstilbestrol; estrogen; hydroxyprogesterone caproate; progesterone; prolactin; animal experiment; animal model; animal tissue; article; controlled study; female; hyperpituitarism; hypophysis; nonhuman; priority journal; prolactin release; protein expression; rat; reverse transcription polymerase chain reaction; Western blotting; 17-alpha-Hydroxyprogesterone; Analysis of Variance; Animals; Calcium Signaling; Diethylstilbestrol; Down-Regulation; Estrogens, Non-Steroidal; Female; Hyperplasia; Pituitary Diseases; Pituitary Gland; Prolactin; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Up-Regulation
Año:2004
Volumen:286
Número:5 49-5
Página de inicio:E786
Página de fin:E794
DOI: http://dx.doi.org/10.1152/ajpendo.00477.2003
Título revista:American Journal of Physiology - Endocrinology and Metabolism
Título revista abreviado:Am. J. Physiol. Endocrinol. Metab.
ISSN:01931849
CODEN:AJPMD
CAS:diethylstilbestrol, 30498-85-2, 56-53-1; hydroxyprogesterone caproate, 630-56-8; progesterone, 57-83-0; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; 17-alpha-Hydroxyprogesterone, 68-96-2; Diethylstilbestrol, 56-53-1; Estrogens, Non-Steroidal; Prolactin, 9002-62-4; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01931849_v286_n549-5_pE786_Suarez

Referencias:

  • AbdAlla, S., Lother, H., Abdel-Tawab, A.M., Quitterer, U., The angiotensin II AT2 receptor is an AT1 receptor antagonist (2001) J Biol Chem, 276, pp. 39721-39726
  • AbdAlla, S., Lother, H., Quitterer, U., AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration (2000) Nature, 407, pp. 94-98
  • Armando, I., Terrón, J.A., Falcón-Neri, A., Takeshi, I., Häuser, W., Inagami, T., Increased angiotensin II AT1 receptor expression in paraventricular nucleus and hypothalamic-pituitary-adrenal axis stimulation in AT2 receptor gene disrupted mice (2002) Neuroendocrinology, 76, pp. 137-147
  • Becu-Villalobos, D., Lacau-Mengido, I.M., Thyssen, S.M., Diaz-Torga, G.S., Libertun, C., Effects of LHRH and Ang II on prolactin stimulation are mediated by hypophysial AT1 receptor subtype (1994) Am J Physiol Endocrinol Metab, 266, pp. E274-E278
  • Bonnet, F., Cooper, M.E., Carey, R.M., Casley, D., Cao, Z., Vascular expression of angiotensin type 2 receptor in the adult rat: Influence of angiotensin II infusion (2001) J Hypertens, 19, pp. 1075-1081
  • Brann, D.W., Rao, I., Mahesh, V.B., Antagonism of estrogen-induced prolactin release by progesterone (1988) Biol Reprod, 39, pp. 1067-1073
  • Brosnihan, K.B., Li, P., Ganten, D., Ferrario, C.M., Estrogen protects transgenic hypertensive rats by shifting the vasoconstrictor-vasodilator balance of RAS (1997) Am J Physiol Regul Integr Comp Physiol, 273, pp. R1908-R1915
  • Brue, T., Pellegrini, I., Priou, A., Morange, I., Jaquet, P., Prolactinomas and resistance to dopamine agonists (1992) Horm Res, 38, pp. 84-89
  • Carrière, P.D., De Léan, A., Gutkowska, J., Genest, J., Cantin, M., Chronic estradiol treatment decreases angiotensin II receptor density in the anterior pituitary gland and adrenal cortex but not in the mesenteric artery (1986) Neuroendocrinology, 43, pp. 49-56
  • Chang, K.-J., Lee, T.T.Y., Linares-Cruz, G., Fournier, S., De Lignieres, B., Influences of percutaneous administration of estradiol and progesterone on human breast epithelial cell cycle in vivo (1995) Fertil Steril, 63, pp. 785-791
  • Cho, B., Suh, Y., Yoon, Y., Lee, C., Kim, K., Progesterone inhibits the estrogen-induced prolactin gene expression in the rat pituitary (1993) Mol Cell Endocrinol, 93, pp. 47-52
  • Close, F.T., Freeman, M.E., Effects of ovarian steroid hormones on dopamine-controlled prolactin secretory responses in vitro (1997) Neuroendocrinology, 65, pp. 430-435
  • Deschepper, C.F., The renin-angiotensin system in the pituitary gland (1991) Trends Endocrinol Metab, 2, pp. 104-107
  • Diaz-Torga, G.S., Becu-Villalobos, D., Libertun, C., Ontogeny of angiotensin-induced prolactin release in vivo and in vitro in female and male rats (1994) Neuroendocrinology, 59, pp. 57-62
  • Diaz-Torga, G.S., Gonzalez Iglesias, A., Achaval-Zaia, R., Libertun, C., Becu-Villalobos, D., Angiotensin II-induced Ca2+ mobilization and prolactin release in normal and hyperplastic pituitary cells (1998) Am J Physiol Endocrinol Metab, 274, pp. E534-E540
  • Dudley, D.T., Summerfelt, R.M., Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells (1993) Regul Pept, 44, pp. 199-206
  • Ewert, S., Laesser, M., Johansson, B., Holm, M., Aneman, A., Fandriks, L., The angiotensin II receptor type 2 agonist CGP 42112A stimulates NO production in the porcine jejunal mucosa (2003) BMC Pharmacol, 3, p. 2
  • Goldenberg, I., Grossman, E., Jacobson, K.A., Shneyvays, V., Shainberg, A., Angiotensin II-induced apoptosis in rat cardiomyocyte culture: A possible role of AT1 and AT2 receptors (2001) J Hypertens, 19, pp. 1681-1689
  • Gonzalez Iglesias, A., Diaz-Torga, G., Lux-Lantos, V., Libertun, C., Becu-Villalobos, D., Calcium influx and intracellular stores in angiotensin II stimulation of normal and hyperplastic pituitary cells (1999) Am J Physiol Endocrinol Metab, 277, pp. E455-E463
  • Gonzalez Iglesias, A., Diaz-Torga, G., Piroli, G., Achaval-Zaia, R., De Nicola, A.F., Libertun, C., Becu-Villalobos, D., Bromocriptine restores angiotensin II response in pituitary hyperplasia (2000) Mol Cell Endocrinol, 165, pp. 67-74
  • Gonzalez Iglesias, A., Suarez, C., Feierstein, C., Diaz-Torga, G., Becu-Villalobos, D., Desensitization of angiotensin II: Effect on [Ca2+]i, inositol triphosphate, and prolactin in pituitary cells (2001) Am J Physiol Endocrinol Metab, 280, pp. E462-E470
  • Harrison-Bernard, L.M., El-Dahr, S.S., O'Leary, D.F., Navar, L.G., Regulation of angiotensin II type 1 receptor mRNA and protein in angiotensin II-induced hypertension (1999) Hypertension, 33, pp. 340-346
  • Healy, D.P., Ye, M.-Q., Yuan, L.-X., Schachter, B.S., Stimulation of angiotensinogen mRNA levels in rat pituitary by estradiol (1992) Am J Physiol Endocrinol Metab, 263, pp. E355-E361
  • Hein, L., Meinel, L., Dzau, V.J., Kobilka, B.K., Intracellular trafficking of angiotensin II and its AT1 and AT2 receptors: Evidence for selective sorting of receptor and ligand (1997) Mol Endocrinol, 11, pp. 1266-1277
  • Horiuchi, M., Lehtonen, J.Y.A., Daviet, L., Signaling mechanism of the AT2 angiotensin II receptor: Crosstalk between AT1 and AT2 receptors in cell growth (1999) Trends Endocrinol Metab, 10, pp. 391-395
  • Hsueh, A.J.W., Peck, E.J., Clark, J.H., Progesterone antagonism of the estrogen receptor and estrogen-induced uterine growth (1975) Nature, 254, pp. 337-339
  • Huang, S.W., Tsai, S.C., Tung, Y.F., Wang, P.S., Role of progesterone in regulating the effect of estradiol on the secretion of thyrotropin-releasing hormone and dopamine into hypophysial portal blood in ovariectomized rats (1995) Neuroendocrinology, 61, pp. 536-541
  • Inagami, T., Guo, D.F., Kitami, Y., Molecular biology of angiotensin II receptors: An overview (1994) J Hypertens Suppl, 12, pp. 583-594
  • Iwai, N., Inagami, T., Regulation of the expression of the rat angiotensin II receptor mRNA (1992) Biochem Biophys Res Commun, 182, pp. 1094-1099
  • Kambayashi, Y., Bardhan, S., Takahashi, K., Tsuzuki, S., Inui, H., Hamakubo, T., Inagami, T., Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition (1993) J Biol Chem, 268, pp. 24543-24546
  • Lenkei, Z., Nuyt, A.M., Grouselle, D., Corvol, P., Llorens-Cortes, C., Identification of endocrine cell population expressing the AT 1B subtype of angiotensin II receptors in anterior pituitary (1999) Endocrinology, 140, pp. 472-477
  • Leri, A., Fiordaliso, F., Setoguchi, M., Limana, F., Bishopric, N.H., Kajstura, J., Webster, K., Anversa, P., Inhibition of p53 function prevents renin-angiotensin system activation and stretch-mediated myocyte apoptosis (2000) Am J Pathol, 157, pp. 843-857
  • Mancina, R., Susini, T., Renzetti, A., Forti, G., Razzoli, E., Serio, M., Maggi, M., Sex steroid modulation of AT2 receptors in human myometrium (1996) J Clin Endocrinol Metab, 81, pp. 1753-1757
  • Miyata, N., Park, F., Feng Li, X., Cowley, A.W., Distribution of angiotensin AT1 and AT2 receptor subtypes in the rat kidney (1999) Am J Physiol Renal Physiol, 277, pp. F437-F446
  • Nora, E.H., Munzenmaier, D.H., Hansen-Smith, F.M., Lombard, J.H., Greene, A.S., Localization of the ANG II type 2 receptor in the microcirculation of skeletal muscle (1998) Am J Physiol Heart Circ Physiol, 275, pp. H1395-H1403
  • Nouet, S., Nahmias, C., Signal transduction from the angiotensin II AT2 receptor (2000) Trends Endocrinol Metab, 11, pp. 1-6
  • Ozono, R., Wang, Z.Q., Moore, A.F., Inagami, T., Siragy, H.M., Carey, R.M., Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney (1997) Hypertension, 30, pp. 1238-1246
  • Phillips, M.I., Wang, H., Kimura, B., Rejtman, M., Koduri, P., Kalra, S.P., Dynamic changes in hypothalamic angiotensin II levels and release in association with progesterone-induced luteinizing hormone surge (1993) Endocrinology, 132, pp. 1637-1642
  • Piroli, G.G., Grillo, C.A., Ferrini, M.G., Lux-Lantos, V., De Nicola, A.F., Antagonism by progesterone of diethylstilbestrol-induced pituitary tumorigenesis in Fischer 344 rats: Effects on sex steroid receptors and tyrosine hydroxylase mRNA (1996) Neuroendocrinology, 63, pp. 530-539
  • Pucell, A.G., Hodges, J.C., Sen, I., Bumpus, F.M., Husain, A., Biochemical properties of the ovarian granulosa cell type 2-angiotensin II receptor (1991) Endocrinology, 128, pp. 1947-1959
  • Sanvitto, G.L., Johren, O., Hauser, W., Saavedra, J.M., Water deprivation upregulates AngII AT1 binding and mRNA in rat subfornical organ and anterior pituitary (1997) Am J Physiol Endocrinol Metab, 273, pp. E156-E163
  • Seltzer, A., Pinto, J.E.B., Viglione, P.N., Correa, F.M.A., Libertun, C., Tsutsumi, K., Steele, M.K., Saavedra, J.M., Estrogens regulate angiotensin-converting enzyme and angiotensin receptors in female rat anterior pituitary (1992) Neuroendocrinology, 55, pp. 460-467
  • Sharma, M., Sharma, R., Greene, A.S., McCarthy, E.T., Savin, V.J., Documentation of angiotensin II receptors in glomerular epithelial cells (1998) Am J Physiol Renal Physiol, 274, pp. F623-F627
  • Sharma, R., Sharma, M., Vamos, S., Savin, V.J., Wiegmann, T.B., Both subtype 1 and 2 receptors of angiotensin II participate in regulation of intracellular calcium in glomerular epithelial cells (2001) J Lab Clin Med, 138, pp. 40-49
  • Shelat, S.G., King, J.L., Flanagan-Cato, L.M., Fluharty, S.J., Mineralocorticoids and glucocorticoids cooperatively increase salt intake and angiotensin II receptor binding in rat brain (1999) Neuroendocrinology, 69, pp. 339-351
  • Su, J.Z., Fukuda, N., Jin, X.Q., Lai, Y.M., Suzuki, M., Tahira, Y., Takagi, H., Miyazaki, H., Effect of AT2 receptor on expression of AT1 and TGF-beta receptors in VSMCs from SHR (2002) Hypertension, 40, pp. 853-858
  • Suarez, C., Diaz-Torga, G., Gonzalez-Iglesias, A., Vela, J., Mladovan, A., Baldi, A., Becu-Villalobos, D., Angiotensin II phosphorylation of extracellular signal-regulated kinases in rat anterior pituitary cells (2003) Am J Physiol Endocrinol Metab, 285, pp. E645-E653
  • Subrahmanyam, C.S., Cassidy, B., Busch, H., Rothblum, L.I., Nucleotide sequence of the region between the 18S rRNA sequence and the 28S rRNA sequence of rat ribosomal DNA (1982) Nucleic Acids Res, 10, pp. 3667-3680
  • Tanaka, M., Tsuchida, S., Imai, T., Fujii, N., Miyazaki, H., Ichiki, T., Naruse, M., Inagami, T., Vascular response to angiotensin II is exaggerated through an upregulation of AT1 receptor in AT2 knockout mice (1999) Biochem Biophys Res Commun, 258, pp. 194-198
  • Tsai, S.C., Lu, C.C., Lau, C.P., Hwang, G.S., Lee, H.Y., Chen, S.L., Huang, S.W., Wang, P.S., Progesterone stimulates in vitro release of prolactin and thyrotropin involving cAMP production in rat pituitary (1996) Chin J Physiol, 39, pp. 245-251
  • Unger, T., The angiotensin type 2 receptor: Variations on an enigmatic theme (1999) J Hypertens, 17, pp. 1775-1786
  • Wintour, E.M., Moritz, K., Butkus, A., Baird, R., Albiston, A., Tenis, N., Ontogeny and regulation of the AT1 and AT2 receptors in the ovine fetal adrenal gland (1999) Mol Cell Endocrinol, 157, pp. 161-170
  • Ying, C., Gregg, D.W., Gorski, J., Estrogen-induced changes in rRNA accumulation and RNA polymerase I activity in the rat pituitary: Correlation with pituitary tumor susceptibility (1996) Mol Cell Endocrinol, 118, p. 213

Citas:

---------- APA ----------
Suarez, C., Díaz-Torga, G., González-Iglesias, A., Cristina, C. & Becu-Villalobos, D. (2004) . Upregulation of angiotensin II type 2 receptor expression in estrogen-induced pituitary hyperplasia. American Journal of Physiology - Endocrinology and Metabolism, 286(5 49-5), E786-E794.
http://dx.doi.org/10.1152/ajpendo.00477.2003
---------- CHICAGO ----------
Suarez, C., Díaz-Torga, G., González-Iglesias, A., Cristina, C., Becu-Villalobos, D. "Upregulation of angiotensin II type 2 receptor expression in estrogen-induced pituitary hyperplasia" . American Journal of Physiology - Endocrinology and Metabolism 286, no. 5 49-5 (2004) : E786-E794.
http://dx.doi.org/10.1152/ajpendo.00477.2003
---------- MLA ----------
Suarez, C., Díaz-Torga, G., González-Iglesias, A., Cristina, C., Becu-Villalobos, D. "Upregulation of angiotensin II type 2 receptor expression in estrogen-induced pituitary hyperplasia" . American Journal of Physiology - Endocrinology and Metabolism, vol. 286, no. 5 49-5, 2004, pp. E786-E794.
http://dx.doi.org/10.1152/ajpendo.00477.2003
---------- VANCOUVER ----------
Suarez, C., Díaz-Torga, G., González-Iglesias, A., Cristina, C., Becu-Villalobos, D. Upregulation of angiotensin II type 2 receptor expression in estrogen-induced pituitary hyperplasia. Am. J. Physiol. Endocrinol. Metab. 2004;286(5 49-5):E786-E794.
http://dx.doi.org/10.1152/ajpendo.00477.2003