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Abstract:

It has been previously demonstrated that murine alloimmune lymphoid cells were able to exert positive or negative inotropic effects on isolated mouse atria depending on the cellular type used. Here we show that BALB/c anti-C3H B-cells induced positive inotropic action on C3H mouse atria. Supernatants of alloimmunized B-cells co-cultivated with C3H myocardium exerted the same biological effect as alloimmune B-cells, indicating that a soluble factor is involved. Inhibitors of lipoxygenase(s) of arachidonic acid metabolism and a SRS-A blocker inhibited the positive effect of immune cells or its supernatants. The effect was prevented when we inhibited the atria lipoxygenase activity. On the other hand, when the inhibitors were applied to effector cells the response was not modified. In addition, supernatants of B-cells cultured with alloextracts were inactive. Supernatants from alloimmune B-cells plus myocardium release higher amounts of LTC4 than those from normal B-cells. It is proposed that SRS-A synthesis is induced in the atria by direct contact with alloimmune B-cells upon recognition of alloantigens expressed by atria cells; which in turn, triggers the positive inotropic effect. © 1988.

Registro:

Documento: Artículo
Título:Alloimmune B-lymphocytes modify the myocardium contractility-inducing release of SRS-A
Autor:Genaro, A.M.; Borda, E.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET), Serrano 665, 1414 Buenos Aires, Argentina
Palabras clave:alloantigen; slow reacting substance; animal; article; B lymphocyte; heart atrium; heart contraction; heart muscle; immunology; in vitro study; mouse; mouse strain; Animal; B-Lymphocytes; Heart Atrium; In Vitro; Isoantigens; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Myocardial Contraction; Myocardium; SRS-A; Support, Non-U.S. Gov't
Año:1988
Volumen:10
Número:5
Página de inicio:563
Página de fin:568
DOI: http://dx.doi.org/10.1016/0192-0561(88)90074-4
Título revista:International Journal of Immunopharmacology
Título revista abreviado:Int. J. Immunopharmacol.
ISSN:01920561
CODEN:IJIMD
CAS:Isoantigens; SRS-A
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01920561_v10_n5_p563_Genaro

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Citas:

---------- APA ----------
Genaro, A.M. & Borda, E. (1988) . Alloimmune B-lymphocytes modify the myocardium contractility-inducing release of SRS-A. International Journal of Immunopharmacology, 10(5), 563-568.
http://dx.doi.org/10.1016/0192-0561(88)90074-4
---------- CHICAGO ----------
Genaro, A.M., Borda, E. "Alloimmune B-lymphocytes modify the myocardium contractility-inducing release of SRS-A" . International Journal of Immunopharmacology 10, no. 5 (1988) : 563-568.
http://dx.doi.org/10.1016/0192-0561(88)90074-4
---------- MLA ----------
Genaro, A.M., Borda, E. "Alloimmune B-lymphocytes modify the myocardium contractility-inducing release of SRS-A" . International Journal of Immunopharmacology, vol. 10, no. 5, 1988, pp. 563-568.
http://dx.doi.org/10.1016/0192-0561(88)90074-4
---------- VANCOUVER ----------
Genaro, A.M., Borda, E. Alloimmune B-lymphocytes modify the myocardium contractility-inducing release of SRS-A. Int. J. Immunopharmacol. 1988;10(5):563-568.
http://dx.doi.org/10.1016/0192-0561(88)90074-4