Artículo

Sciutto, E.; Fragoso, G.; Manoutcharian, K.; Gevorkian, G.; Rosas-Salgado, G.; Hernández-Gonzalez, M.; Herrera-Estrella, L.; Cabrera-Ponce, J.L.; López-Casillas, F.; González-Bonilla, C.; Santiago-Machuca, A.; Ruíz-Pérez, F.; Sánchez, J.; Goldbaum, F.; Aluja, A.; Larralde, C. "New approaches to improve a peptide vaccine against porcine Taenia solium cysticercosis" (2002) Archives of Medical Research. 33(4):371-378
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Abstract:

Cysticercosis caused by Taenia solium frequently affects human health and rustic porciculture. Cysticerci may localize in the central nervous system of humans causing neurocysticercosis, a major health problem in undeveloped countries. Prevalence and intensity of this disease in pigs and humans are related to social factors (poor personal hygiene, low sanitary conditions, rustic rearing of pigs, open fecalism) and possibly to biological factors such as immunity, genetic background, and gender. The indispensable role of pigs as an obligatory intermediate host in the life cycle offers the possibility of interfering with transmission through vaccination of pigs. An effective vaccine based on three synthetic peptides against pig cysticercosis has been successfully developed and proved effective in experimental and field conditions. The well-defined peptides that constitute the cysticercosis vaccine offer the possibility to explore alternative forms of antigen production and delivery systems that may improve the cost/benefit of this and other vaccines. Encouraging results were obtained in attempts to produce large amounts of these peptides and increased its immunogenicity by expression in recombinant filamentous phage (M13), in transgenic plants (carrots and papaya), and associated to bacterial immunogenic carrier proteins. © 2002 IMSS. Published by Elsevier Science Inc.

Registro:

Documento: Artículo
Título:New approaches to improve a peptide vaccine against porcine Taenia solium cysticercosis
Autor:Sciutto, E.; Fragoso, G.; Manoutcharian, K.; Gevorkian, G.; Rosas-Salgado, G.; Hernández-Gonzalez, M.; Herrera-Estrella, L.; Cabrera-Ponce, J.L.; López-Casillas, F.; González-Bonilla, C.; Santiago-Machuca, A.; Ruíz-Pérez, F.; Sánchez, J.; Goldbaum, F.; Aluja, A.; Larralde, C.
Filiación:Departamento de Inmunología, Inst. de Investigaciones Biomedicas, Mexico City, Mexico
Departamento de Biología Celular, Instituto de Fisiología Celular, Mexico City, Mexico
Departamento de Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico
Unidad de Medicina Biomolecular, Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
Unidad de Investigación Médica en Inmunología e Infectología, Hospital de Infectología, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico
Departamento de Ingeniería Genética de Plantas, Unidad de Biotecnología e Ingeniería Genética de Plantas, Centro de Investigaciones y de Estudios, Avanzados del Instituto Politécnico Nacional (CINVESTAV del IPN), Irapuato, Guanajuato, Mexico
Facultad de Ciencias Exactas y Naturales, Instituto de Investigaciones Bioquímicas Dr. Luis F. Leloir, Fundación Campomar, Buenos Aires, Argentina
Palabras clave:Antigen delivery; Cysticercosis; Synthetic vaccine; Taenia crassiceps; Taenia solium; Vaccination; carrier protein; vaccine; bacteriophage; central nervous system; conference paper; cost benefit analysis; cost effectiveness analysis; cysticercosis; developing country; disease severity; disease transmission; host parasite interaction; human; immunity; immunogenicity; infection prevention; infection rate; neurocysticercosis; nonhuman; personal hygiene; pig farming; sex difference; swine; Taenia solium; transgenic plant; vaccination; Animals; Base Sequence; Cholera Toxin; Cysticercosis; Cysticercus; Humans; Molecular Sequence Data; Plants, Genetically Modified; Plasmids; Recombinant Fusion Proteins; Swine; Swine Diseases; Vaccination; Vaccines, Subunit
Año:2002
Volumen:33
Número:4
Página de inicio:371
Página de fin:378
DOI: http://dx.doi.org/10.1016/S0188-4409(02)00376-4
Título revista:Archives of Medical Research
Título revista abreviado:Arch. Med. Res.
ISSN:01884409
CAS:Cholera Toxin, 9012-63-9; Recombinant Fusion Proteins; Vaccines, Subunit
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01884409_v33_n4_p371_Sciutto

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Citas:

---------- APA ----------
Sciutto, E., Fragoso, G., Manoutcharian, K., Gevorkian, G., Rosas-Salgado, G., Hernández-Gonzalez, M., Herrera-Estrella, L.,..., Larralde, C. (2002) . New approaches to improve a peptide vaccine against porcine Taenia solium cysticercosis. Archives of Medical Research, 33(4), 371-378.
http://dx.doi.org/10.1016/S0188-4409(02)00376-4
---------- CHICAGO ----------
Sciutto, E., Fragoso, G., Manoutcharian, K., Gevorkian, G., Rosas-Salgado, G., Hernández-Gonzalez, M., et al. "New approaches to improve a peptide vaccine against porcine Taenia solium cysticercosis" . Archives of Medical Research 33, no. 4 (2002) : 371-378.
http://dx.doi.org/10.1016/S0188-4409(02)00376-4
---------- MLA ----------
Sciutto, E., Fragoso, G., Manoutcharian, K., Gevorkian, G., Rosas-Salgado, G., Hernández-Gonzalez, M., et al. "New approaches to improve a peptide vaccine against porcine Taenia solium cysticercosis" . Archives of Medical Research, vol. 33, no. 4, 2002, pp. 371-378.
http://dx.doi.org/10.1016/S0188-4409(02)00376-4
---------- VANCOUVER ----------
Sciutto, E., Fragoso, G., Manoutcharian, K., Gevorkian, G., Rosas-Salgado, G., Hernández-Gonzalez, M., et al. New approaches to improve a peptide vaccine against porcine Taenia solium cysticercosis. Arch. Med. Res. 2002;33(4):371-378.
http://dx.doi.org/10.1016/S0188-4409(02)00376-4