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Abstract:

Four experiments using T-2 toxin and nivalenol at different dosage, which represented the 25% and 40% of the LD50 (experiment A: 1.04 mg of T-2 toxin per kilogram of body weight, experiment B: 2.34 mg of T-2 toxin/kg b.w., experiment C: 1.04 mg of T-2 toxin/kg b. w. and 2.34 mg of T-2 toxin/kg b.w.; experiment D: 0.82 mg of nivalenol/kg b.w. and 1.845 mg of nivalenol/kg b.w.) were conducted on 400 mice. Both toxins were administered to mice of different ages (experiments A and B were adults, experiment C and D were young) by intraperitoneal single injection, and the clinical signs, hematological variables and histoanatomo pathological changes were studied. All animals survived. No changes anatomo-histopathological nor significative differences in weight gain were observed. Different behaviors were found for nivalenol and T-2 toxin. The most significant change was the increase in the level of monocytes in old animals, so this could be a biological indicator for T-2 toxin subclinical intoxication. © 1994 Society of Mycotoxin Research and Springer.

Registro:

Documento: Artículo
Título:Subclinic effect of the administration of T-2 Toxin and Nivalenol in mice
Autor:Ana, P.; Carlos, R.; Hebe, M.; Graciela, O.; Graciela, B.
Filiación:Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CIC), Buenos Aires, Argentina
Universidad Nacional de Luján, Buenos Aires, Argentina
Universidad Nacional del Sur, Buenos Aires, Argentina
Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), Argentina
Año:1994
Volumen:10
Número:2
Página de inicio:85
Página de fin:96
DOI: http://dx.doi.org/10.1007/BF03192257
Título revista:Mycotoxin Research
Título revista abreviado:Mycotox Res
ISSN:01787888
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01787888_v10_n2_p85_Ana

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Citas:

---------- APA ----------
Ana, P., Carlos, R., Hebe, M., Graciela, O. & Graciela, B. (1994) . Subclinic effect of the administration of T-2 Toxin and Nivalenol in mice. Mycotoxin Research, 10(2), 85-96.
http://dx.doi.org/10.1007/BF03192257
---------- CHICAGO ----------
Ana, P., Carlos, R., Hebe, M., Graciela, O., Graciela, B. "Subclinic effect of the administration of T-2 Toxin and Nivalenol in mice" . Mycotoxin Research 10, no. 2 (1994) : 85-96.
http://dx.doi.org/10.1007/BF03192257
---------- MLA ----------
Ana, P., Carlos, R., Hebe, M., Graciela, O., Graciela, B. "Subclinic effect of the administration of T-2 Toxin and Nivalenol in mice" . Mycotoxin Research, vol. 10, no. 2, 1994, pp. 85-96.
http://dx.doi.org/10.1007/BF03192257
---------- VANCOUVER ----------
Ana, P., Carlos, R., Hebe, M., Graciela, O., Graciela, B. Subclinic effect of the administration of T-2 Toxin and Nivalenol in mice. Mycotox Res. 1994;10(2):85-96.
http://dx.doi.org/10.1007/BF03192257