Artículo
Piroli, G.; Grillo, C.; Lux de Lantos, V.; Libertun, C.; De Nicola, A.F. "Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors" (1991) Neuroendocrinology Letters. 13(2):75-81
Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor
Abstract:
In estrogen-induced pituitary tumors, binding of (3H)-dexamethasone (DEX) to soluble glucocorticoid receptors (GCR) was reduced 5-6 fold with respect to normal pituitaries. GCR in the tumors, however, bound normally to DNA-cellulose after heat-induced transformation. In control rats, serum prolactin (PRL) increased after ether stress and decreased following DEX treatment, whereas these maneuvres failed to change the hyperprolactinemia of rats with pituitary tumors. Thus, in rats with experimental prolactinomas, impaired negative feedback of serum PRL to DEX seems to correlate with a low content of functional GCR.
Registro:
| Documento: | Artículo |
| Título: | Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors |
| Autor: | Piroli, G.; Grillo, C.; Lux de Lantos, V.; Libertun, C.; De Nicola, A.F. |
| Filiación: | Neuroendocr. Biochemistry Lab., Instituto de Biologia, Obligado 2490, 1428 Buenos Aires, Argentina |
| Palabras clave: | dexamethasone; glucocorticoid receptor; prolactin; animal experiment; animal model; article; controlled study; feedback system; hypophysis tumor; male; nonhuman; priority journal; rat |
| Año: | 1991 |
| Volumen: | 13 |
| Número: | 2 |
| Página de inicio: | 75 |
| Página de fin: | 81 |
| Título revista: | Neuroendocrinology Letters |
| Título revista abreviado: | NEUROENDOCRINOL. LETT. |
| ISSN: | 0172780X |
| CODEN: | NLETD |
| CAS: | dexamethasone, 50-02-2; prolactin, 12585-34-1, 50647-00-2, 9002-62-4 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0172780X_v13_n2_p75_Piroli |
Citas:
---------- APA ----------
Piroli, G., Grillo, C., Lux de Lantos, V., Libertun, C. & De Nicola, A.F. (1991) . Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors. Neuroendocrinology Letters, 13(2), 75-81.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0172780X_v13_n2_p75_Piroli [ ]
---------- CHICAGO ----------
Piroli, G., Grillo, C., Lux de Lantos, V., Libertun, C., De Nicola, A.F. "Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors" . Neuroendocrinology Letters 13, no. 2 (1991) : 75-81.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0172780X_v13_n2_p75_Piroli [ ]
---------- MLA ----------
Piroli, G., Grillo, C., Lux de Lantos, V., Libertun, C., De Nicola, A.F. "Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors" . Neuroendocrinology Letters, vol. 13, no. 2, 1991, pp. 75-81.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0172780X_v13_n2_p75_Piroli [ ]
---------- VANCOUVER ----------
Piroli, G., Grillo, C., Lux de Lantos, V., Libertun, C., De Nicola, A.F. Glucocorticoid receptors and inhibition of serum prolactin by dexamethasone are reduced in rats with estrogen-induced pituitary tumors. NEUROENDOCRINOL. LETT. 1991;13(2):75-81.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0172780X_v13_n2_p75_Piroli [ ]
