Abstract:
External proton and 6,7Li beams, of energies around 24 and 48 MeV respectively, were produced and characterized dosimetrically at the Tandem accelerator TANDAR in Buenos Aires and used for radiobiology studies on tumor and normal cell cultures. The beam monitoring instrumentation of a dedicated beam line is discussed. Relative biological effectiveness (RBE) values (at 10% survival) have been measured as functions of projectile energy (0-21 MeV) for protons and 6,7Li ions for different tumor (PDV, PDVC57) and reference cell lines (V79). The RBE values for these cell lines have been determined here for the first time but are similar to those reported in the literature for other cell lines. © 2002 Elsevier Science B.V. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells |
Autor: | Schuff, J.A.; Policastro, L.; Durán, H.; Kreiner, A.J; Mazal, A.; Molinari, B.L.; Burlón, A.; Debray, M.E.; Kesque, J.M.; Somacal, H.; Stoliar, P.; Valda, A.; Bernaola, O.A.; Perez de la Hoz, A.; Saint-Martin, G.; O'Connor, S.; Davidson, J.; Davidson, M.; Naab, F.; Ozafrán, M.J.; Vázquez, M.E.; Cáneva, S.; Delacroix, S.; Favaudon, F.; Henry, Y.; Nauraye, C.; Brune, E.; Gautier, C.; Habrand, J.L.; Palmieri, M.; Ruffolo, M. |
Filiación: | Departamento de Física, Comisión Nacional de Energia Atomica, CP 1429, Buenos Aires, Argentina Escuela de Ciencia y Tecnologia, Universidad de San Martin, Villa Ballester 1653, Argentina Departamento de Radiobiologia, Comision Nacional de Energia Atomica, San Martin 1650, Argentina CONICET, Capital 1030, Argentina Centre de Protontherapie d'Orsay, Orsay 91406, France Lnstitut Curie, Paris 75231, France Departamento de Biologia, Facultad de Ciencias Exactas y Naturales, Ciuded Universitaria 1428, Argentina Departamento de Fisica, Comisin Nacional de Energa, Universidad de Buenos Aires, Libertador 8250, 1429 Buenos Aires, Argentina
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Idioma: |
Inglés
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Palabras clave: | 6,7Li ions; Cells; Dosimetry; Instrumentation; Protons; RBE; Biological radiation effects; Cell culture; Dosimetry; Lithium; Particle accelerators; Radiotherapy; Tumors; Radiobiology; Proton beams |
Año: | 2002
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Volumen: | 187
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Número: | 3
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Página de inicio: | 345
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Página de fin: | 353
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DOI: |
http://dx.doi.org/10.1016/S0168-583X(01)01136-3 |
Título revista: | Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
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Título revista abreviado: | Nucl Instrum Methods Phys Res Sect B
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ISSN: | 0168583X
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CODEN: | NIMBE
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0168583X_v187_n3_p345_Schuff |
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Citas:
---------- APA ----------
Schuff, J.A., Policastro, L., Durán, H., Kreiner, A.J, Mazal, A., Molinari, B.L., Burlón, A.,..., Ruffolo, M.
(2002)
. Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, 187(3), 345-353.
http://dx.doi.org/10.1016/S0168-583X(01)01136-3---------- CHICAGO ----------
Schuff, J.A., Policastro, L., Durán, H., Kreiner, A.J, Mazal, A., Molinari, B.L., et al.
"Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells"
. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms 187, no. 3
(2002) : 345-353.
http://dx.doi.org/10.1016/S0168-583X(01)01136-3---------- MLA ----------
Schuff, J.A., Policastro, L., Durán, H., Kreiner, A.J, Mazal, A., Molinari, B.L., et al.
"Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells"
. Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, vol. 187, no. 3, 2002, pp. 345-353.
http://dx.doi.org/10.1016/S0168-583X(01)01136-3---------- VANCOUVER ----------
Schuff, J.A., Policastro, L., Durán, H., Kreiner, A.J, Mazal, A., Molinari, B.L., et al. Relative biological effectiveness measurements of low energy proton and lithium beams on tumor cells. Nucl Instrum Methods Phys Res Sect B. 2002;187(3):345-353.
http://dx.doi.org/10.1016/S0168-583X(01)01136-3