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Abstract:

The structure of scleroglucan gel matrices was characterized by dynamic rheological studies. The results were compared with the release kinetics of theophylline in analogous samples using a Franz diffusion cell, fitting the drug release data with a semi-empirical power law. Dynamic rheology gave information about the viscous and elastic components (loss and storage moduli, respectively) of the gel which could influence the drug-release profiles. Scleroglucan gels showed two structural transitions within the gel regime that coincided with changes in the release pattern. It was found that the introduction of 0.4% (w/w) of theophylline decreased the loss and storage moduli in the 2% (w/w) scleroglucan gels by 50%. The influence of the same wt.% theophylline in other gels was strongly dependent on the gel concentration. These results demonstrated the value of rheological studies to detect matrix structural changes produced by the inclusion of drugs which may modify the drug-release profile. © 2003 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices
Autor:François, N.J.; Rojas, A.M.; Daraio, M.E.; Bernik, D.L.
Filiación:Lab. de Quim. de Sist. Heterogeneos, Facultad de Ingeniería, Universidad de Buenos Aires, Paseo Colón 850, C1063ACV Buenos Aires, Argentina
Departamento de Industrias, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
Inst. Quim. Fis. Mat., Ambiente y E., INQUIMAE, Universidad de Buenos Aires, 3er Piso, C1428EHA Buenos Aires, Argentina
Palabras clave:Drug release; Dynamic rheology; Hydrophilic matrices; Scleroglucan; Elasticity; Gels; Reaction kinetics; Rheology; Viscosity; Franz diffusion cells; Controlled drug delivery; scleroglucan; theophylline; article; drug release; drug structure; elasticity; flow kinetics; gel; priority journal; viscosity
Año:2003
Volumen:90
Número:3
Página de inicio:355
Página de fin:362
DOI: http://dx.doi.org/10.1016/S0168-3659(03)00204-9
Título revista:Journal of Controlled Release
Título revista abreviado:J. Control. Release
ISSN:01683659
CODEN:JCREE
CAS:scleroglucan, 39464-87-4; theophylline, 58-55-9, 5967-84-0, 8055-07-0, 8061-56-1, 99007-19-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01683659_v90_n3_p355_Francois

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Citas:

---------- APA ----------
François, N.J., Rojas, A.M., Daraio, M.E. & Bernik, D.L. (2003) . Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices. Journal of Controlled Release, 90(3), 355-362.
http://dx.doi.org/10.1016/S0168-3659(03)00204-9
---------- CHICAGO ----------
François, N.J., Rojas, A.M., Daraio, M.E., Bernik, D.L. "Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices" . Journal of Controlled Release 90, no. 3 (2003) : 355-362.
http://dx.doi.org/10.1016/S0168-3659(03)00204-9
---------- MLA ----------
François, N.J., Rojas, A.M., Daraio, M.E., Bernik, D.L. "Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices" . Journal of Controlled Release, vol. 90, no. 3, 2003, pp. 355-362.
http://dx.doi.org/10.1016/S0168-3659(03)00204-9
---------- VANCOUVER ----------
François, N.J., Rojas, A.M., Daraio, M.E., Bernik, D.L. Dynamic rheological measurements and drug release kinetics in swollen scleroglucan matrices. J. Control. Release. 2003;90(3):355-362.
http://dx.doi.org/10.1016/S0168-3659(03)00204-9