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Abstract:

The influence of glycoprotein processing, cleavage and transport on Junin virus (JV) infectivity was investigated using monensin combined with lectin binding assays. Yields of extracellular virus were more significantly reduced than cell-associated virus, indicating that monensin inhibited the transport of infectious virus to the extracellular space on a late stage of the replicative cycle. Shown by lectin reactivity and immunoprecipitation, the intracellular processing of JV glycoproteins involved first the maturation of GPC oligosaccharides to a complex form and then the precursor cleavage which might occur late in transit through or exit from the Golgi cisternae. Cleavage of GPC to yield the mature GP38 as well as cell surface immunofluorescence were blocked by monensin. Thus, GP38 production together with glycoprotein transport to the cell membrane seemed to be required for the release of infectious virus from JV-infected cells. © 1994.

Registro:

Documento: Artículo
Título:Intracellular processing and transport of Junin virus glycoproteins influences virion infectivity
Autor:Damonte, E.B.; Mersich, S.E.; Candurra, N.A.
Filiación:Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellon 2, Piso 4, 1428 Buenos Aires, Argentina
Palabras clave:Arenavirus; Glycoprotein processing; Glycoprotein transport; Junin virus; Monensin; monensin; virus glycoprotein; animal cell; article; controlled study; junin virus; nonhuman; priority journal; protein processing; protein transport; virion; virus infectivity; Animal; Biological Transport; Cercopithecus aethiops; Fluorescent Antibody Technique; Glycoproteins; Junin virus; Lectins; Monensin; Peptide Hydrolases; Protein Processing, Post-Translational; Support, Non-U.S. Gov't; Vero Cells; Viral Envelope Proteins; Viral Proteins; Virus Replication; Animalia; Arenavirus; Junin virus
Año:1994
Volumen:34
Número:3
Página de inicio:317
Página de fin:326
DOI: http://dx.doi.org/10.1016/0168-1702(94)90131-7
Título revista:Virus Research
Título revista abreviado:Virus Res.
ISSN:01681702
CODEN:VIRED
CAS:Glycoproteins; Lectins; Monensin, 17090-79-8; Peptide Hydrolases, EC 3.4; Viral Envelope Proteins; Viral Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01681702_v34_n3_p317_Damonte

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Citas:

---------- APA ----------
Damonte, E.B., Mersich, S.E. & Candurra, N.A. (1994) . Intracellular processing and transport of Junin virus glycoproteins influences virion infectivity. Virus Research, 34(3), 317-326.
http://dx.doi.org/10.1016/0168-1702(94)90131-7
---------- CHICAGO ----------
Damonte, E.B., Mersich, S.E., Candurra, N.A. "Intracellular processing and transport of Junin virus glycoproteins influences virion infectivity" . Virus Research 34, no. 3 (1994) : 317-326.
http://dx.doi.org/10.1016/0168-1702(94)90131-7
---------- MLA ----------
Damonte, E.B., Mersich, S.E., Candurra, N.A. "Intracellular processing and transport of Junin virus glycoproteins influences virion infectivity" . Virus Research, vol. 34, no. 3, 1994, pp. 317-326.
http://dx.doi.org/10.1016/0168-1702(94)90131-7
---------- VANCOUVER ----------
Damonte, E.B., Mersich, S.E., Candurra, N.A. Intracellular processing and transport of Junin virus glycoproteins influences virion infectivity. Virus Res. 1994;34(3):317-326.
http://dx.doi.org/10.1016/0168-1702(94)90131-7