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Goddio, M.V.; Gattelli, A.; Slomiansky, V.; Lacunza, E.; Gingerich, T.; Tocci, J.M.; Facchinetti, M.M.; Curino, A.C.; LaMarre, J.; Abba, M.C.; Kordon, E.C. "Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein" (2012) Breast Cancer Research and Treatment. 135(3):749-758
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Abstract:

Tristetraprolin (TTP) is a RNA-binding protein that inhibits the expression of pro-inflammatory cytokines and invasiveness-associated genes. TTP levels are decreased in many different cancer types and it has been proposed that this protein could be used as a prognostic factor in breast cancer. Here, using publicly available DNA microarray datasets, "serial analysis of gene expression" libraries and qRT-PCR analysis, we determined that TTP mRNA is present in normal breast cells and its levels are significantly decreased in all breast cancer subtypes. In addition, by immunostaining, we found that TTP expression is higher in normal breast tissue and benign lesions than in infiltrating carcinomas. Among these, lower grade tumors showed increased TTP expression compared to higher grade cancers. Therefore, these data indicate that TTP protein levels would provide a better negative correlation with breast cancer invasiveness than TTP transcript levels. In mice, we found that TTP mRNA and protein expression is also diminished in mammary tumors. Interestingly, a strong positive association of TTP expression and mammary differentiation was identified in normal and tumor cells. In fact, TTP expression is highly increased during lactation, showing good correlation with various mammary differentiation factors. TTP expression was also induced in mammary HC11 cells treated with lactogenic hormones, mainly by prolactin, through Stat5A activation. The effect of this hormone was highly dependent on mammary differentiation status, as prolactin was unable to elicit a similar response in proliferating or neoplastic mammary cells. In summary, these studies show that TTP expression is strongly linked to the mammary differentiation program in human and mice, suggesting that this protein might play specific and relevant roles in the normal physiology of the gland. © Springer Science+Business Media, LLC. 2012.

Registro:

Documento: Artículo
Título:Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein
Autor:Goddio, M.V.; Gattelli, A.; Slomiansky, V.; Lacunza, E.; Gingerich, T.; Tocci, J.M.; Facchinetti, M.M.; Curino, A.C.; LaMarre, J.; Abba, M.C.; Kordon, E.C.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
CINIBA, Facultad de Ciencias Médicas, Universidad Nacional de la Plata, La Plata, Argentina
OntarioVeterinarian College, University of Guelph, ON, Canada
Laboratorio de Biología Del Cáncer, INIBIBB-CONICET, Centro Científico Tecnológico, Bahía Blanca, Argentina
Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, CM1, Pabellón 2, 2do piso, 1428 Ciudad Autónoma de Buenos Aires, Argentina
Palabras clave:Breast cancer; Lactation; Mammary gland; Prolactin; Tristetraprolin; messenger RNA; prolactin; RNA binding protein; STAT5a protein; tristetraprolin; 3' untranslated region; animal tissue; article; AU rich element; breast cancer; breast carcinoma; breast cell; breast lesion; breast tumor; cancer cell; cancer grading; cancer invasion; cell proliferation; controlled study; DNA microarray; gene expression; human; human tissue; immunohistochemistry; lactation; mammary gland; mouse; nonhuman; priority journal; protein expression; reverse transcription polymerase chain reaction; serial analysis of gene expression; tissue differentiation; Animals; Base Sequence; Breast Neoplasms; Cell Differentiation; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Lactation; Mammary Glands, Animal; Mammary Glands, Human; Mammary Neoplasms, Animal; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Pregnancy; Prolactin; STAT5 Transcription Factor; Tristetraprolin; Tumor Suppressor Proteins
Año:2012
Volumen:135
Número:3
Página de inicio:749
Página de fin:758
DOI: http://dx.doi.org/10.1007/s10549-012-2216-0
Título revista:Breast Cancer Research and Treatment
Título revista abreviado:Breast Cancer Res. Treat.
ISSN:01676806
CODEN:BCTRD
CAS:STAT5a protein, 176744-10-8; prolactin, 12585-34-1, 50647-00-2, 9002-62-4; Prolactin, 9002-62-4; STAT5 Transcription Factor; STAT5A protein, human; Tristetraprolin; Tumor Suppressor Proteins; ZFP36 protein, human; Zfp36 protein, mouse
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01676806_v135_n3_p749_Goddio

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Citas:

---------- APA ----------
Goddio, M.V., Gattelli, A., Slomiansky, V., Lacunza, E., Gingerich, T., Tocci, J.M., Facchinetti, M.M.,..., Kordon, E.C. (2012) . Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein. Breast Cancer Research and Treatment, 135(3), 749-758.
http://dx.doi.org/10.1007/s10549-012-2216-0
---------- CHICAGO ----------
Goddio, M.V., Gattelli, A., Slomiansky, V., Lacunza, E., Gingerich, T., Tocci, J.M., et al. "Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein" . Breast Cancer Research and Treatment 135, no. 3 (2012) : 749-758.
http://dx.doi.org/10.1007/s10549-012-2216-0
---------- MLA ----------
Goddio, M.V., Gattelli, A., Slomiansky, V., Lacunza, E., Gingerich, T., Tocci, J.M., et al. "Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein" . Breast Cancer Research and Treatment, vol. 135, no. 3, 2012, pp. 749-758.
http://dx.doi.org/10.1007/s10549-012-2216-0
---------- VANCOUVER ----------
Goddio, M.V., Gattelli, A., Slomiansky, V., Lacunza, E., Gingerich, T., Tocci, J.M., et al. Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein. Breast Cancer Res. Treat. 2012;135(3):749-758.
http://dx.doi.org/10.1007/s10549-012-2216-0