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Abstract:

Isolated hepatocytes from rats with experimental diabetes exhibit increased content of cytochrome P-450 and cyclic AMP and normal activities of the regulatory enzymes δ-aminolevulinic acid synthase and ferrochelatase. The inducing effect exerted by phenobarbital on cytochrome P-450, δ-aminolevulinic acid synthase and ferrochelatase biosynthesis and cyclic AMP content in diabetic hepatic cells is markedly greater than that observed in normal hepatocytes. This stimulatory response is neither enhanced by added dibutyryl cyclic AMP nor repressed by glucose. The present results suggest that the heme pathway of diabetic hepatocytes is more susceptible to porphyrinogenic factors. © 1985.

Registro:

Documento: Artículo
Título:Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats
Autor:Cánepa, E.T.; Galvagno, M.A.; Llambías, E.B.C.; Passeron, S.; Grinstein, M.
Filiación:Laboratorio de Porfirinas and Programa de Regulación Hormonal y Metabólica, Departamento de Quimica Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, (1428) Buenos Aires Argentina
Palabras clave:(Diabetic rat hepatocyte); cyclic AMP; Cytochrome P-450; Enzyme induction; Ferrochelatase; δ-Aminolevulinic acid synthase; 5 aminolevulinate synthase; cyclic amp; cytochrome p450; ferrochelatase; heme; animal model; biosynthesis; diabetes mellitus; endocrine system; etiology; experimental diabetes mellitus; liver; liver cell; nonhuman; priority journal; rat; 5-Aminolevulinate Synthetase; Animals; Bucladesine; Cyclic AMP; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Ferrochelatase; Glucose; Heme; Homeostasis; Kinetics; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values
Año:1985
Volumen:847
Número:2
Página de inicio:191
Página de fin:197
DOI: http://dx.doi.org/10.1016/0167-4889(85)90020-5
Título revista:BBA - Molecular Cell Research
Título revista abreviado:Biochim. Biophys. Acta Mol. Cell Res.
ISSN:01674889
CODEN:BAMRD
CAS:5 aminolevulinate synthase, 9037-14-3; cyclic AMP, 60-92-4; cytochrome P450, 9035-51-2; ferrochelatase, 9012-93-5; heme, 14875-96-8; 5-Aminolevulinate Synthetase, 2.3.1.37; Bucladesine, 362-74-3; Cyclic AMP, 60-92-4; Cytochrome P-450 Enzyme System, 9035-51-2; Ferrochelatase, 4.99.1.1; Glucose, 50-99-7; Heme, 14875-96-8; Phenobarbital, 50-06-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674889_v847_n2_p191_Canepa

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Citas:

---------- APA ----------
Cánepa, E.T., Galvagno, M.A., Llambías, E.B.C., Passeron, S. & Grinstein, M. (1985) . Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats. BBA - Molecular Cell Research, 847(2), 191-197.
http://dx.doi.org/10.1016/0167-4889(85)90020-5
---------- CHICAGO ----------
Cánepa, E.T., Galvagno, M.A., Llambías, E.B.C., Passeron, S., Grinstein, M. "Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats" . BBA - Molecular Cell Research 847, no. 2 (1985) : 191-197.
http://dx.doi.org/10.1016/0167-4889(85)90020-5
---------- MLA ----------
Cánepa, E.T., Galvagno, M.A., Llambías, E.B.C., Passeron, S., Grinstein, M. "Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats" . BBA - Molecular Cell Research, vol. 847, no. 2, 1985, pp. 191-197.
http://dx.doi.org/10.1016/0167-4889(85)90020-5
---------- VANCOUVER ----------
Cánepa, E.T., Galvagno, M.A., Llambías, E.B.C., Passeron, S., Grinstein, M. Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from experimental-diabetic rats. Biochim. Biophys. Acta Mol. Cell Res. 1985;847(2):191-197.
http://dx.doi.org/10.1016/0167-4889(85)90020-5