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Abstract:

The present work shows that allylisopropylacetamide exerts an inducing effect on δ-aminolevulinic acid synthase and ferrochelatase activities in isolated rat hepatocytes of normal adult rats. Dibutyryl cyclic AMP enhances the inducing effect produced in both enzymes. Glucose inhibits the induction of δ-aminolevulinic acid synthase and ferrochelatase in this in vitro system. A similar effect was observed with fructose and 2-deoxyglucose. No glucose effect was observed with galactose, mannose, glycerol, pyruvate and lactate. The glucose effect can be reversed with increasing concentrations of dibutyryl cyclic AMP. The simple in vitro method used in the present work promises to be a very useful tool for studies of regulatory mechanisms of porphyrin and heme biosynthesis in hepatocytes under normal and pathological conditions (hepatic porphyrias). © 1984.

Registro:

Documento: Artículo
Título:Effect of glucose on the induction of δ-aminolevulinic acid synthase and ferrochelatase in isolated rat hepatocytes by allylisopropylacetamide
Autor:Canepa, E.; Llambias, E.B.C.; Grinstein, M.
Filiación:Laboratorio de Porfirinas, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Núñez, (1428) Buenos Aires Argentina
Palabras clave:(Rat hepatocyte); Enzyme induction; Ferrochelatase; Glucose; δ-Aminolevulinate synthase; allylisopropylacetamide; bucladesine; cycloheximide; deoxyglucose; ferrochelatase; fructose; galactose; glucose; glycerol; lactic acid; mannose; porphobilinogen synthase; pyruvic acid; alkylisopropylacetamide; drug efficacy; enzyme induction; in vitro study; liver; liver cell; nonhuman; rat; 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animal; Bucladesine; Carbohydrates; Cycloheximide; Enzyme Induction; Ferrochelatase; Gene Expression Regulation; Glucose; Heme; Liver; Lyases; Male; Rats; Support, Non-U.S. Gov't
Año:1984
Volumen:804
Número:1
Página de inicio:8
Página de fin:15
DOI: http://dx.doi.org/10.1016/0167-4889(84)90092-2
Título revista:BBA - Molecular Cell Research
Título revista abreviado:Biochim. Biophys. Acta Mol. Cell Res.
ISSN:01674889
CODEN:BAMRD
CAS:allylisopropylacetamide, 299-78-5; bucladesine, 16980-89-5, 362-74-3; cycloheximide, 642-81-9, 66-81-9; deoxyglucose, 154-17-6; ferrochelatase, 9012-93-5; fructose, 30237-26-4, 57-48-7, 7660-25-5, 77907-44-9; galactose, 26566-61-0, 50855-33-9, 59-23-4; glucose, 50-99-7, 84778-64-3; glycerol, 56-81-5; lactic acid, 113-21-3, 50-21-5; mannose, 31103-86-3, 3458-28-4; porphobilinogen synthase, 9036-37-7; pyruvic acid, 127-17-3, 19071-34-2, 57-60-3; 5-Aminolevulinate Synthetase, EC 2.3.1.37; Allylisopropylacetamide, 299-78-5; Bucladesine, 362-74-3; Carbohydrates; Cycloheximide, 66-81-9; Ferrochelatase, EC 4.99.1.1; Glucose, 50-99-7; Heme, 14875-96-8; Lyases, EC 4.
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674889_v804_n1_p8_Canepa

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Citas:

---------- APA ----------
Canepa, E., Llambias, E.B.C. & Grinstein, M. (1984) . Effect of glucose on the induction of δ-aminolevulinic acid synthase and ferrochelatase in isolated rat hepatocytes by allylisopropylacetamide. BBA - Molecular Cell Research, 804(1), 8-15.
http://dx.doi.org/10.1016/0167-4889(84)90092-2
---------- CHICAGO ----------
Canepa, E., Llambias, E.B.C., Grinstein, M. "Effect of glucose on the induction of δ-aminolevulinic acid synthase and ferrochelatase in isolated rat hepatocytes by allylisopropylacetamide" . BBA - Molecular Cell Research 804, no. 1 (1984) : 8-15.
http://dx.doi.org/10.1016/0167-4889(84)90092-2
---------- MLA ----------
Canepa, E., Llambias, E.B.C., Grinstein, M. "Effect of glucose on the induction of δ-aminolevulinic acid synthase and ferrochelatase in isolated rat hepatocytes by allylisopropylacetamide" . BBA - Molecular Cell Research, vol. 804, no. 1, 1984, pp. 8-15.
http://dx.doi.org/10.1016/0167-4889(84)90092-2
---------- VANCOUVER ----------
Canepa, E., Llambias, E.B.C., Grinstein, M. Effect of glucose on the induction of δ-aminolevulinic acid synthase and ferrochelatase in isolated rat hepatocytes by allylisopropylacetamide. Biochim. Biophys. Acta Mol. Cell Res. 1984;804(1):8-15.
http://dx.doi.org/10.1016/0167-4889(84)90092-2