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Abstract:

Erythropoietin (Epo) promotes the development of erythroid progenitors by triggering intracellular signals through the binding to its specific receptor (EpoR). Previous results related to the action of aluminum (Al) on erythropoiesis let us suggest that the metal affects Epo interaction with its target cells. In order to investigate this effect on cell activation by the Epo-EpoR complex, two human cell lines with different dependence on Epo were subjected to Al exposure. In the Epo-independent K562 cells, Al inhibited Epo antiapoptotic action and triggered a simultaneous decrease in protein and mRNA EpoR levels. On the other hand, proliferation of the strongly Epo-dependent UT-7 cells was enhanced by long-term Al treatment, in agreement with the upregulation of EpoR expression during Epo starvation. Results provide some clues to the way by which Epo supports cell survival and growth, and demonstrate that not all the intracellular factors needed to guarantee the different signaling pathways of Epo-cell activation are available or activated in cells expressing EpoR. This study then suggests that at least one of the mechanisms by which Al interfere with erythropoiesis might involve EpoR modulation. © 2004 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor
Autor:Vittori, D.; Pregi, N.; Pérez, G.; Garbossa, G.; Nesse, A.
Filiación:Lab. de Analisis Biologicos, Depto. de Quím. Biol., Ciudad Universitaria, Ciudad de Buenos Aires (C1428EHA), Argentina
Palabras clave:Aluminum; Apoptosis; Erythropoietin; Erythropoietin receptor; K562 cell; UT-7 cell line; aluminum; erythropoietin; erythropoietin receptor; apoptosis; article; cell activation; cell growth; cell line; cell proliferation; cell survival; controlled study; human; human cell; priority journal; protein expression; signal transduction
Año:2005
Volumen:1743
Número:1-2
Página de inicio:29
Página de fin:36
DOI: http://dx.doi.org/10.1016/j.bbamcr.2004.08.004
Título revista:Biochimica et Biophysica Acta - Molecular Cell Research
Título revista abreviado:Biochim. Biophys. Acta Mol. Cell Res.
ISSN:01674889
CODEN:BAMRD
CAS:aluminum, 7429-90-5; erythropoietin, 11096-26-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674889_v1743_n1-2_p29_Vittori

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Citas:

---------- APA ----------
Vittori, D., Pregi, N., Pérez, G., Garbossa, G. & Nesse, A. (2005) . The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor. Biochimica et Biophysica Acta - Molecular Cell Research, 1743(1-2), 29-36.
http://dx.doi.org/10.1016/j.bbamcr.2004.08.004
---------- CHICAGO ----------
Vittori, D., Pregi, N., Pérez, G., Garbossa, G., Nesse, A. "The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor" . Biochimica et Biophysica Acta - Molecular Cell Research 1743, no. 1-2 (2005) : 29-36.
http://dx.doi.org/10.1016/j.bbamcr.2004.08.004
---------- MLA ----------
Vittori, D., Pregi, N., Pérez, G., Garbossa, G., Nesse, A. "The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor" . Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1743, no. 1-2, 2005, pp. 29-36.
http://dx.doi.org/10.1016/j.bbamcr.2004.08.004
---------- VANCOUVER ----------
Vittori, D., Pregi, N., Pérez, G., Garbossa, G., Nesse, A. The distinct erythropoietin functions that promote cell survival and proliferation are affected by aluminum exposure through mechanisms involving erythropoietin receptor. Biochim. Biophys. Acta Mol. Cell Res. 2005;1743(1-2):29-36.
http://dx.doi.org/10.1016/j.bbamcr.2004.08.004