Abstract:
Amino-acid starvation in polyamine-auxotrophic bacteria grown in the presence of putrescine provokes a marked inhibition of protein synthesis. This inhibition is almost completely relieved in polyamine-depleted cells. The differential behaviour of bacterial protein synthesis depending on the endogenous levels of polyamines is not due to a change in the uptake of amino acids used to measure protein synthesis, nor to the decreased growth rate of polyamine-depleted cells. During leucine starvation, cells grown with putrescine synthesized a somewhat lower amount of high-molecular-weight proteins than polyamine-depleted bacteria. In addition, cells with normal endogenous levels of polyamines accumulated significant amounts of 62 and 41 kDa polypeptides as well as several low-molecular-weight peptides. © 1988.
Registro:
Documento: |
Artículo
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Título: | Protein synthesis in polyamine-deficient bacteria during amino-acid starvation |
Autor: | Nastri, H.G.; Algranati, I.D. |
Filiación: | Instituto de Investigaciones Bioquimicas 'Fundacion Campomar', Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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Palabras clave: | (E. coli); Amino acid starvation; Polyamide auxotrophy; Translation; amino acid; bacterial protein; polyamine; putrescine; article; biosynthesis; drug effect; Escherichia coli; genetics; kinetics; metabolism; molecular weight; transport at the cellular level; Amino Acids; Bacterial Proteins; Biological Transport; Escherichia coli; Kinetics; Molecular Weight; Polyamines; Putrescine; Support, Non-U.S. Gov't |
Año: | 1988
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Volumen: | 949
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Número: | 1
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Página de inicio: | 65
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Página de fin: | 70
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DOI: |
http://dx.doi.org/10.1016/0167-4781(88)90055-3 |
Título revista: | BBA - Gene Structure and Expression
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Título revista abreviado: | Biochim. Biophys. Acta Gene Struct. Expr.
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ISSN: | 01674781
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CODEN: | BBGSD
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CAS: | amino acid, 65072-01-7; putrescine, 110-60-1, 333-93-7; Amino Acids; Bacterial Proteins; Polyamines; Putrescine, 110-60-1
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674781_v949_n1_p65_Nastri |
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Citas:
---------- APA ----------
Nastri, H.G. & Algranati, I.D.
(1988)
. Protein synthesis in polyamine-deficient bacteria during amino-acid starvation. BBA - Gene Structure and Expression, 949(1), 65-70.
http://dx.doi.org/10.1016/0167-4781(88)90055-3---------- CHICAGO ----------
Nastri, H.G., Algranati, I.D.
"Protein synthesis in polyamine-deficient bacteria during amino-acid starvation"
. BBA - Gene Structure and Expression 949, no. 1
(1988) : 65-70.
http://dx.doi.org/10.1016/0167-4781(88)90055-3---------- MLA ----------
Nastri, H.G., Algranati, I.D.
"Protein synthesis in polyamine-deficient bacteria during amino-acid starvation"
. BBA - Gene Structure and Expression, vol. 949, no. 1, 1988, pp. 65-70.
http://dx.doi.org/10.1016/0167-4781(88)90055-3---------- VANCOUVER ----------
Nastri, H.G., Algranati, I.D. Protein synthesis in polyamine-deficient bacteria during amino-acid starvation. Biochim. Biophys. Acta Gene Struct. Expr. 1988;949(1):65-70.
http://dx.doi.org/10.1016/0167-4781(88)90055-3