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Schijman, A.G.; Vazquez, M.P.; Dov, C.B.; Ghio, S.; Lorenzi, H.; Levin, M.J. "Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi" (1995) BBA - Gene Structure and Expression. 1264(1):15-18
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Abstract:

P2β acidic ribosomal protein is a relevant antigen in Chagas' disease. cDNA cloning demonstrated that Trypanosoma cruzi expresses at least six types of TcP2β transcripts that differed by point nucleotides substitutions. The distribution and type of mutations seemed to follow the typical structural organization of eukaryotic acidic ribosomal proteins. Most of the synonymous changes clustered in the amino-terminus, suggesting that conservation of this domain was crucial for an equivalent functional ability of each TcP2β variant to bind to the ribosome. Interestingly, most amino acid changes in the central-globular and hinge domains caused polymorphism in putative phosphorylatable sites. © 1995.

Registro:

Documento: Artículo
Título:Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi
Autor:Schijman, A.G.; Vazquez, M.P.; Dov, C.B.; Ghio, S.; Lorenzi, H.; Levin, M.J.
Filiación:Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular (INGEBI), Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
Palabras clave:Acidic ribosomal protein; Chagas' disease; Multigene family; Phosphorylation site; gene transcript; ribosome protein; unclassified drug; amino acid sequence; article; chagas disease; molecular cloning; multigene family; nonhuman; nucleotide sequence; phosphorylation; priority journal; trypanosoma cruzi; Amino Acid Sequence; Animal; Base Sequence; Cloning, Molecular; DNA, Complementary; Molecular Sequence Data; Mutation; Ribosomal Proteins; Sequence Alignment; Support, Non-U.S. Gov't; Trypanosoma cruzi; Eukaryota; Trypanosoma; Trypanosoma cruzi
Año:1995
Volumen:1264
Número:1
Página de inicio:15
Página de fin:18
DOI: http://dx.doi.org/10.1016/0167-4781(95)00142-4
Título revista:BBA - Gene Structure and Expression
Título revista abreviado:Biochim. Biophys. Acta Gene Struct. Expr.
ISSN:01674781
CODEN:BBGSD
CAS:DNA, Complementary; Ribosomal Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674781_v1264_n1_p15_Schijman

Referencias:

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Citas:

---------- APA ----------
Schijman, A.G., Vazquez, M.P., Dov, C.B., Ghio, S., Lorenzi, H. & Levin, M.J. (1995) . Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi. BBA - Gene Structure and Expression, 1264(1), 15-18.
http://dx.doi.org/10.1016/0167-4781(95)00142-4
---------- CHICAGO ----------
Schijman, A.G., Vazquez, M.P., Dov, C.B., Ghio, S., Lorenzi, H., Levin, M.J. "Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi" . BBA - Gene Structure and Expression 1264, no. 1 (1995) : 15-18.
http://dx.doi.org/10.1016/0167-4781(95)00142-4
---------- MLA ----------
Schijman, A.G., Vazquez, M.P., Dov, C.B., Ghio, S., Lorenzi, H., Levin, M.J. "Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi" . BBA - Gene Structure and Expression, vol. 1264, no. 1, 1995, pp. 15-18.
http://dx.doi.org/10.1016/0167-4781(95)00142-4
---------- VANCOUVER ----------
Schijman, A.G., Vazquez, M.P., Dov, C.B., Ghio, S., Lorenzi, H., Levin, M.J. Cloning and sequence analysis of the TcP2β cDNA variants of Trypanosoma cruzi. Biochim. Biophys. Acta Gene Struct. Expr. 1995;1264(1):15-18.
http://dx.doi.org/10.1016/0167-4781(95)00142-4