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Abstract:

The effects of intracellular levels of polyamines on both the in vivo inhibition of protein synthesis and the decrease of translation accuracy induced by streptomycin have been studied in polyamine-auxotrophic strains of Escherichia coli infected with the MS2 bacteriophage. The amount of viral coat protein formed was strongly reduced upon addition of increasing concentrations of streptomycin to polyamine-supplemented bacteria. In contrast, the antibiotic almost did not inhibit coat protein synthesis in polyamine-starved cells. The increase of mistranslation frequency elicited by streptomycin was only observed in bacteria grown with putrescine. In these cells several coat protein-satellites were detected after two-dimensional gel electrophoresis. These proteins, more basic than the normal MS2 coat protein, contain multiple substitutions of lysine for asparagine. © 1993.

Registro:

Documento: Artículo
Título:Polyamines modulate streptomycin-induced mistranslation in Escherichia coli
Autor:Nastri, H.G.; Fastame, I.G.; Algranati, I.D.
Filiación:Instituto de Investigaciones Bioquímicas 'Fundación Campomar', Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, A. Machado 151, 1405 Buenos Aires, Argentina
Palabras clave:(E. coli); Polyamine; Streptomycin; Translation fidelity; coat protein; polyamine; streptomycin; article; bacteriophage; controlled study; escherichia coli; nonhuman; priority journal; rna translation; virus infection; Autoradiography; Bacterial Proteins; Capsid; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Levivirus; Methionine; Molecular Weight; Polyamines; Streptomycin; Support, Non-U.S. Gov't; Translation, Genetic; Escherichia coli
Año:1993
Volumen:1216
Número:3
Página de inicio:455
Página de fin:459
DOI: http://dx.doi.org/10.1016/0167-4781(93)90014-5
Título revista:BBA - Gene Structure and Expression
Título revista abreviado:Biochim. Biophys. Acta Gene Struct. Expr.
ISSN:01674781
CODEN:BBGSD
CAS:Bacterial Proteins; Methionine, 63-68-3; Polyamines; Streptomycin, 57-92-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01674781_v1216_n3_p455_Nastri

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Citas:

---------- APA ----------
Nastri, H.G., Fastame, I.G. & Algranati, I.D. (1993) . Polyamines modulate streptomycin-induced mistranslation in Escherichia coli. BBA - Gene Structure and Expression, 1216(3), 455-459.
http://dx.doi.org/10.1016/0167-4781(93)90014-5
---------- CHICAGO ----------
Nastri, H.G., Fastame, I.G., Algranati, I.D. "Polyamines modulate streptomycin-induced mistranslation in Escherichia coli" . BBA - Gene Structure and Expression 1216, no. 3 (1993) : 455-459.
http://dx.doi.org/10.1016/0167-4781(93)90014-5
---------- MLA ----------
Nastri, H.G., Fastame, I.G., Algranati, I.D. "Polyamines modulate streptomycin-induced mistranslation in Escherichia coli" . BBA - Gene Structure and Expression, vol. 1216, no. 3, 1993, pp. 455-459.
http://dx.doi.org/10.1016/0167-4781(93)90014-5
---------- VANCOUVER ----------
Nastri, H.G., Fastame, I.G., Algranati, I.D. Polyamines modulate streptomycin-induced mistranslation in Escherichia coli. Biochim. Biophys. Acta Gene Struct. Expr. 1993;1216(3):455-459.
http://dx.doi.org/10.1016/0167-4781(93)90014-5