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Florin-Christensen, M.; Florin-Christensen, J.; De Isola, E.D.; Lammel, E.; Meinardi, E.; Brenner, R.R.; Rasmussen, L. "Temperature acclimation of Trypanosoma cruzi epimastigote and metacyclic trypomastigote lipids" (1997) Molecular and Biochemical Parasitology. 88(1-2):25-33
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Abstract:

This study examines the changes in cellular lipids that take place when Trypanosoma cruzi epimastigotes and metacyclic trypomastigotes are transferred from 28 to 37°C. We found a rise in the sterol to phospholipid ratio, as well as in the triacylglycerol and steryl ester cellular content in T. cruzi epimastigotes. In addition, saturated to unsaturated fatty acid ratios in phospholipids increase. This latter effect appears to be due to two concurrent processes. Firstly, fatty acyl Δ9 and, especially, Δ12 desaturations are significantly diminished at 37°C. Secondly, triacylglycerols and steryl esters undergo changes in their fatty acyl composition opposite to those simultaneously observed in phospholipids, i.e. the ratio of saturated to unsaturated fatty acids markedly decreases. Similar alterations in each of the lipid classes and in the fatty acid composition of polar and neutral lipids were found in cultured metacyclic trypomastigotes on exposure to the same shift-up. These observations suggest that a global remodeling of cellular lipids that involves extensive fatty acid exchange between neutral and polar lipid pools represents a novel and important mechanism of adaptation of the parasites to the temperature changes they encounter in their life cycle.

Registro:

Documento: Artículo
Título:Temperature acclimation of Trypanosoma cruzi epimastigote and metacyclic trypomastigote lipids
Autor:Florin-Christensen, M.; Florin-Christensen, J.; De Isola, E.D.; Lammel, E.; Meinardi, E.; Brenner, R.R.; Rasmussen, L.
Filiación:Institute of Neuroscience (INEUCI), CONICET-UBA, Ciudad Universitaria, 4o Piso, RA-1428 Buenos Aires, Argentina
Institute of Biochemistry (INIBIOLP), CONICET-UNLP, Avenida 60 y 120, RA-1900 La Plata, Argentina
Department of Microbiology, Univ. of Buenos Aires Medical School, Paraguay 1256, RA-1113 Buenos Aires, Argentina
Dept. of Anatomy and Cell Biology, Odense University, Campusvej 55, DK-5230 Odense M, Denmark
INEUCI-CONICET, Casilla de Correo 137, (RA-1663) San Miguel, Argentina
Palabras clave:Fatty acids; Lipids; Phospholipids; Sterols; Temperature; Trypanosoma cruzi; fatty acid; lipid; sterol; article; epimastigote; fatty acid desaturation; life cycle; lipid composition; lipid metabolism; priority journal; temperature acclimatization; trypanosoma cruzi; trypomastigote; Adaptation, Physiological; Animals; Fatty Acid Desaturases; Fatty Acids; Lipid Metabolism; Lipids; Phospholipids; Sterols; Temperature; Triglycerides; Trypanosoma cruzi; Trypanosoma; Trypanosoma cruzi
Año:1997
Volumen:88
Número:1-2
Página de inicio:25
Página de fin:33
DOI: http://dx.doi.org/10.1016/S0166-6851(97)00056-X
Título revista:Molecular and Biochemical Parasitology
Título revista abreviado:MOL. BIOCHEM. PARASITOL.
ISSN:01666851
CODEN:MBIPD
CAS:Fatty Acid Desaturases, EC 1.14.99.-; Fatty Acids; Lipids; Phospholipids; Sterols; Triglycerides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01666851_v88_n1-2_p25_FlorinChristensen

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Citas:

---------- APA ----------
Florin-Christensen, M., Florin-Christensen, J., De Isola, E.D., Lammel, E., Meinardi, E., Brenner, R.R. & Rasmussen, L. (1997) . Temperature acclimation of Trypanosoma cruzi epimastigote and metacyclic trypomastigote lipids. Molecular and Biochemical Parasitology, 88(1-2), 25-33.
http://dx.doi.org/10.1016/S0166-6851(97)00056-X
---------- CHICAGO ----------
Florin-Christensen, M., Florin-Christensen, J., De Isola, E.D., Lammel, E., Meinardi, E., Brenner, R.R., et al. "Temperature acclimation of Trypanosoma cruzi epimastigote and metacyclic trypomastigote lipids" . Molecular and Biochemical Parasitology 88, no. 1-2 (1997) : 25-33.
http://dx.doi.org/10.1016/S0166-6851(97)00056-X
---------- MLA ----------
Florin-Christensen, M., Florin-Christensen, J., De Isola, E.D., Lammel, E., Meinardi, E., Brenner, R.R., et al. "Temperature acclimation of Trypanosoma cruzi epimastigote and metacyclic trypomastigote lipids" . Molecular and Biochemical Parasitology, vol. 88, no. 1-2, 1997, pp. 25-33.
http://dx.doi.org/10.1016/S0166-6851(97)00056-X
---------- VANCOUVER ----------
Florin-Christensen, M., Florin-Christensen, J., De Isola, E.D., Lammel, E., Meinardi, E., Brenner, R.R., et al. Temperature acclimation of Trypanosoma cruzi epimastigote and metacyclic trypomastigote lipids. MOL. BIOCHEM. PARASITOL. 1997;88(1-2):25-33.
http://dx.doi.org/10.1016/S0166-6851(97)00056-X