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Abstract:

A shadow passing overhead acts as a danger stimulus and elicits an escape response in the crab Chasmagnathus that habituates promptly and for a long period. Robust retention is shown at 24 h after 15 trials of shadow presentation or at 120 h after 30 trials, but no significant retention is disclosed at 24 h after 5 trials or at 72 h after 15. A cocktail of the cAMP membrane permeable analog 8-(4-chlorophenylthio)-cAMP (CPT-cAMP), plus the phosphodiesterase inhibitor isobutyl methylxanthine (IBMX), was given by systemic administration. Pretraining injection of the cocktail (25 or 50 μM, 15 min before a 5-trial session) failed to affect short-term habituation, but induced significant retention when tested at 24 h. This facilitatory effect was not shown when a lower dose (5 μM) was used. A pest-training injection of 25 μM, immediately after a 5- or 15-trial session, induced retention when tested at 24 or 72 h, respectively. Thus, the administration of CPT-cAMP + IBMX during acquisition of a habituated response or immediately after, improves long-term habituation, a result supporting the view that an increase in the cAMP level is one of the steps in long-term memory consolidation.

Registro:

Documento: Artículo
Título:Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus
Autor:Romano, A.; Delorenzi, A.; Pedreira, M.E.; Tomsic, D.; Maldonado, H.
Filiación:Lab. Fisiol. Comportamiento Anim., Fac. de Ciencias Exactas Y Naturales, Buenos Aires University, 1428 Buenos Aires, Argentina
Palabras clave:(CPT-cAMP); 8-(4-Chlorophenylthio)cyclic adenosine monophosphate; Crustacean; Cyclic adenosine monophosphate (cAMP); Learning; Long-term habituation; Memory; 8 (4 chlorophenylthio) cyclic AMP; cyclic AMP derivative; isobutylmethylxanthine; adolescent; animal experiment; article; controlled study; crab; intramuscular drug administration; learning; male; memory; nonhuman; priority journal
Año:1996
Volumen:75
Número:1-2
Página de inicio:119
Página de fin:125
DOI: http://dx.doi.org/10.1016/0166-4328(96)00179-9
Título revista:Behavioural Brain Research
Título revista abreviado:BEHAV. BRAIN RES.
ISSN:01664328
CODEN:BBRED
CAS:8 (4 chlorophenylthio) cyclic AMP, 41941-66-6; isobutylmethylxanthine, 28822-58-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01664328_v75_n1-2_p119_Romano

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Citas:

---------- APA ----------
Romano, A., Delorenzi, A., Pedreira, M.E., Tomsic, D. & Maldonado, H. (1996) . Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus. Behavioural Brain Research, 75(1-2), 119-125.
http://dx.doi.org/10.1016/0166-4328(96)00179-9
---------- CHICAGO ----------
Romano, A., Delorenzi, A., Pedreira, M.E., Tomsic, D., Maldonado, H. "Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus" . Behavioural Brain Research 75, no. 1-2 (1996) : 119-125.
http://dx.doi.org/10.1016/0166-4328(96)00179-9
---------- MLA ----------
Romano, A., Delorenzi, A., Pedreira, M.E., Tomsic, D., Maldonado, H. "Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus" . Behavioural Brain Research, vol. 75, no. 1-2, 1996, pp. 119-125.
http://dx.doi.org/10.1016/0166-4328(96)00179-9
---------- VANCOUVER ----------
Romano, A., Delorenzi, A., Pedreira, M.E., Tomsic, D., Maldonado, H. Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus. BEHAV. BRAIN RES. 1996;75(1-2):119-125.
http://dx.doi.org/10.1016/0166-4328(96)00179-9