Artículo

Urbano, F.J.; Bisagno, V.; Garcia-Rill, E. "Arousal and drug abuse" (2017) Behavioural Brain Research. 333:276-281
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Abstract:

The reticular activating system (RAS) is not an amorphous region but distinct nuclei with specific membrane properties that dictate their firing during waking and sleep. The locus coeruleus and raphe nucleus fire during waking and slow wave sleep, with the pedunculopontine nucleus (PPN) firing during both waking and REM sleep, the states manifesting arousal-related EEG activity. Two important discoveries in the PPN in the last 10 years are, 1) that some PPN cells are electrically coupled, and 2) every PPN cell manifests high threshold calcium channels that allow them to oscillate at beta/gamma band frequencies. The role of arousal in drug abuse is considered here in terms of the effects of drugs of abuse on these two mechanisms. Drug abuse and the perception of withdrawal/relapse are mediated by neurobiological processes that occur only when we are awake, not when we are asleep. These relationships focus on the potential role of arousal, more specifically of RAS electrical coupling and gamma band activity, in the addictive process as well as the relapse to drug use. © 2017

Registro:

Documento: Artículo
Título:Arousal and drug abuse
Autor:Urbano, F.J.; Bisagno, V.; Garcia-Rill, E.
Filiación:Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, United States
IFIBYNE-CONICET, ININFA-CONICET, University of Buenos Aires, Argentina
Palabras clave:Cocaine; Connexin 36; Dopamine; Modafinil; N- and P/Q-type calcium channels; Preconscious awareness; 4 aminobutyric acid; alpha 2 adrenergic receptor; calcium channel T type; carbachol; catecholamine; cocaine; modafinil; opsin; orexin; rhodopsin; addiction; arousal; beta rhythm; cell nucleus membrane; cholinergic activity; dopaminergic activity; drug abuse; drug craving; drug effect; electroencephalogram; excitation contraction coupling; firing rate; GABAergic system; gamma rhythm; gap junction; high frequency oscillation; human; hypothalamus; locus ceruleus; membrane potential; nonhuman; optogenetics; pedunculopontine tegmental nucleus; priority journal; raphe nucleus; relapse; REM sleep; reticular formation; Review; sleep; sleep waking cycle; slow wave sleep; wakefulness; withdrawal syndrome; animal; arousal; drug dependence; pathophysiology; physiology; Animals; Arousal; Humans; Substance-Related Disorders
Año:2017
Volumen:333
Página de inicio:276
Página de fin:281
DOI: http://dx.doi.org/10.1016/j.bbr.2017.07.013
Título revista:Behavioural Brain Research
Título revista abreviado:Behav. Brain Res.
ISSN:01664328
CODEN:BBRED
CAS:4 aminobutyric acid, 28805-76-7, 56-12-2; carbachol, 462-58-8, 51-83-2; cocaine, 50-36-2, 53-21-4, 5937-29-1; modafinil, 68693-11-8; rhodopsin, 60383-01-9, 9009-81-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01664328_v333_n_p276_Urbano

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Citas:

---------- APA ----------
Urbano, F.J., Bisagno, V. & Garcia-Rill, E. (2017) . Arousal and drug abuse. Behavioural Brain Research, 333, 276-281.
http://dx.doi.org/10.1016/j.bbr.2017.07.013
---------- CHICAGO ----------
Urbano, F.J., Bisagno, V., Garcia-Rill, E. "Arousal and drug abuse" . Behavioural Brain Research 333 (2017) : 276-281.
http://dx.doi.org/10.1016/j.bbr.2017.07.013
---------- MLA ----------
Urbano, F.J., Bisagno, V., Garcia-Rill, E. "Arousal and drug abuse" . Behavioural Brain Research, vol. 333, 2017, pp. 276-281.
http://dx.doi.org/10.1016/j.bbr.2017.07.013
---------- VANCOUVER ----------
Urbano, F.J., Bisagno, V., Garcia-Rill, E. Arousal and drug abuse. Behav. Brain Res. 2017;333:276-281.
http://dx.doi.org/10.1016/j.bbr.2017.07.013