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Abstract:

Praxis functions are predominantly processed by the left hemisphere. However, limb apraxia is found in less than 50% of patients with left hemisphere damage, and also, although infrequently, in patients with right hemisphere damage. We studied brain representation of preparation/planning of tool-use pantomime separating the gestures involving mostly distal limb control (e.g., using scissors) from those involving proximal limb control (e.g., hammering). During the fMRI scan transitive pantomimes were performed with the dominant and the non-dominant hand by right-handed healthy subjects. Random and voxel-based analysis through laterality index (LI) calculation, demonstrated that for both limbs, distal gesture planning was in general left lateralized, while for the proximal condition the representation was found to be more bilateral particularly in the inferior frontal gyrus. LI distributions across subjects indicated that while the majority of subjects are left-hemispheric dominant for praxis, there are a minority with the opposite lateralization. Functional connectivity analysis showed that while the correlation between homolog areas involved in gesture production was high irrespective of gesture type, their correlation to the supplementary motor area was high in proximal but not distal conditions. Therefore, transitive gestures, when pantomimed to verbal commands, are differentially represented inter and intra hemispherically depending on whether the gesture is performed with the right or left arm or whether it involves predominantly distal or proximal limb movements. Furthermore, the representation of the different types of gestures may be related to a modulation of the connectivity between areas involved in motor planning. © 2014 Elsevier B.V.

Registro:

Documento: Artículo
Título:Lateralization of brain activity during motor planning of proximal and distal gestures
Autor:Mäki-Marttunen, V.; Villarreal, M.; Leiguarda, R.C.
Filiación:Neuroscience Department, Institute for Neurological Research, F.L.E.N.I., Montañeses 2325, 1428 Buenos Aires, Argentina
CONICET, Rivadavia 1917, 1033 Buenos Aires, Argentina
Palabras clave:Distal gesture; FMRI; Functional connectivity; Ideomotor apraxia; Praxis planning; Proximal gesture; adult; article; brain function; distal gesture; functional magnetic resonance imaging; gesture; hemispheric dominance; human; human experiment; inferior frontal gyrus; left hemisphere; limb movement; motor performance; normal human; planning; priority journal; proximal gesture; right handedness; supplementary motor area; voxel based morphometry; arm; brain; brain mapping; individuality; nerve tract; nuclear magnetic resonance imaging; physiology; psychomotor performance; Adult; Arm; Brain; Brain Mapping; Functional Laterality; Gestures; Humans; Individuality; Magnetic Resonance Imaging; Neural Pathways; Psychomotor Performance
Año:2014
Volumen:272
Página de inicio:226
Página de fin:237
DOI: http://dx.doi.org/10.1016/j.bbr.2014.06.055
Título revista:Behavioural Brain Research
Título revista abreviado:Behav. Brain Res.
ISSN:01664328
CODEN:BBRED
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01664328_v272_n_p226_MakiMarttunen

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Citas:

---------- APA ----------
Mäki-Marttunen, V., Villarreal, M. & Leiguarda, R.C. (2014) . Lateralization of brain activity during motor planning of proximal and distal gestures. Behavioural Brain Research, 272, 226-237.
http://dx.doi.org/10.1016/j.bbr.2014.06.055
---------- CHICAGO ----------
Mäki-Marttunen, V., Villarreal, M., Leiguarda, R.C. "Lateralization of brain activity during motor planning of proximal and distal gestures" . Behavioural Brain Research 272 (2014) : 226-237.
http://dx.doi.org/10.1016/j.bbr.2014.06.055
---------- MLA ----------
Mäki-Marttunen, V., Villarreal, M., Leiguarda, R.C. "Lateralization of brain activity during motor planning of proximal and distal gestures" . Behavioural Brain Research, vol. 272, 2014, pp. 226-237.
http://dx.doi.org/10.1016/j.bbr.2014.06.055
---------- VANCOUVER ----------
Mäki-Marttunen, V., Villarreal, M., Leiguarda, R.C. Lateralization of brain activity during motor planning of proximal and distal gestures. Behav. Brain Res. 2014;272:226-237.
http://dx.doi.org/10.1016/j.bbr.2014.06.055