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Abstract:

The perinatal development of the nervous system is influenced by different external and internal stimuli. Previous data show that maternal care and perinatal inflammation can induce long-term changes in anxiety- and depression-related behavior. Our hypothesis is that both maternal care and perinatal inflammation act through interacting biological pathways to program adult behavior. To evaluate this interaction, we combined a protocol of maternal care variation in mice (C57BL/6J × BALB/c reciprocal F1 offspring) with the administration of bacterial wall lipopolysaccharide (LPS) at a previously reported sensitive development age (postnatal day 3, P3). The analysis of maternal behavior revealed that pups from C57BL/6J dams received more maternal attention than those taken care by BALB/c dams. Pups receiving LPS at P3 showed an acute corticosterone response, and a dose-dependent desensitization of this hormonal response when challenged with LPS at adulthood. We analyzed adult behavior on 6 highly validated tests and found an interaction between maternal care and early postnatal LPS on 7 anxiety-related behaviors in 4 different tests. In particular, early postnatal LPS treatment resulted in higher anxiety-related behavior when administered to females receiving more maternal care (C57 pedigree), but reduced depression-related behavior in males of the same pedigree. These results suggest that specific coping strategies are sensitive to maternal care and/or postnatal inflammation programming of adult anxiety- and depression-related behaviors, suggesting that both divergent and convergent mechanisms participate in this programming. © 2010 Elsevier B.V.

Registro:

Documento: Artículo
Título:Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors
Autor:Lucchina, L.; Carola, V.; Pitossi, F.; Depino, A.M.
Filiación:Instituto de Fisiolologia, Biologia Molecular y Neurociencias, CONICET-UBA, C1428EHA Buenos Aires, Argentina
Santa Lucia Foundation, European Centre for Brain Research, Via Fosso del Fiorano, 00143 Rome, Italy
Department of Psychology, University La Sapienza, 00185 Rome, Italy
Leloir Institute Foundation, Instituto de Investigaciones Bioquimicas Buenos Aires, CONICET, 1405 Buenos Aires, Argentina
Departamento de Fisiologia y Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Palabras clave:Anxiety behavior; Depression behavior; F1 hybrids; Maternal care; Postnatal inflammation; Principal component analysis; Programming of adult behavior; bacterium lipopolysaccharide; corticosterone; adulthood; animal experiment; animal model; anxiety; article; attention; controlled study; coping behavior; depression; desensitization; developmental stage; female; inflammation; maternal behavior; maternal care; mother child relation; mouse; newborn; nonhuman; pedigree; perinatal period; priority journal; validation process; Aging; Animals; Animals, Newborn; Anxiety; Corticosterone; Depression; Female; Inflammation; Lipopolysaccharides; Male; Maternal Behavior; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neuropsychological Tests; Random Allocation; Sex Factors
Año:2010
Volumen:213
Número:1
Página de inicio:56
Página de fin:65
DOI: http://dx.doi.org/10.1016/j.bbr.2010.04.032
Título revista:Behavioural Brain Research
Título revista abreviado:Behav. Brain Res.
ISSN:01664328
CODEN:BBRED
CAS:corticosterone, 50-22-6; Corticosterone, 50-22-6; Lipopolysaccharides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01664328_v213_n1_p56_Lucchina

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Citas:

---------- APA ----------
Lucchina, L., Carola, V., Pitossi, F. & Depino, A.M. (2010) . Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors. Behavioural Brain Research, 213(1), 56-65.
http://dx.doi.org/10.1016/j.bbr.2010.04.032
---------- CHICAGO ----------
Lucchina, L., Carola, V., Pitossi, F., Depino, A.M. "Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors" . Behavioural Brain Research 213, no. 1 (2010) : 56-65.
http://dx.doi.org/10.1016/j.bbr.2010.04.032
---------- MLA ----------
Lucchina, L., Carola, V., Pitossi, F., Depino, A.M. "Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors" . Behavioural Brain Research, vol. 213, no. 1, 2010, pp. 56-65.
http://dx.doi.org/10.1016/j.bbr.2010.04.032
---------- VANCOUVER ----------
Lucchina, L., Carola, V., Pitossi, F., Depino, A.M. Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors. Behav. Brain Res. 2010;213(1):56-65.
http://dx.doi.org/10.1016/j.bbr.2010.04.032