Artículo

Zapata, J.C.; Pauza, C.D.; Djavani, M.M.; Rodas, J.D.; Moshkoff, D.; Bryant, J.; Ateh, E.; Garcia, C.; Lukashevich, I.S.; Salvato, M.S. "Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever" (2011) Antiviral Research. 92(2):125-138
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Abstract:

Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human beings. LCMV is considerably more benign for human beings than Lassa virus, however certain strains, like the LCMV-WE strain, can cause severe disease when the virus is delivered as a high-dose inoculum. Here we describe a rhesus macaque model for Lassa fever that employs a virulent strain of LCMV. Since LASV must be studied within Biosafety Level-4 (BSL-4) facilities, the LCMV-infected macaque model has the advantage that it can be used at BSL-3. LCMV-induced disease is rarely as severe as other VHF, but it is similar in cases where vascular leakage leads to lethal systemic failure. The LCMV-infected macaque has been valuable for describing the course of disease with differing viral strains, doses and routes of infection. By monitoring system-wide changes in physiology and gene expression in a controlled experimental setting, it is possible to identify events that are pathognomonic for developing VHF and potential treatment targets. © 2011 Elsevier B.V.

Registro:

Documento: Artículo
Título:Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever
Autor:Zapata, J.C.; Pauza, C.D.; Djavani, M.M.; Rodas, J.D.; Moshkoff, D.; Bryant, J.; Ateh, E.; Garcia, C.; Lukashevich, I.S.; Salvato, M.S.
Filiación:Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States
Grupo de Investigaciones en Ciencias Veterinarias Centauro, Facultad de Ciencias Agrarias, Universidad de Antioquia, Medellín, Colombia
Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Palabras clave:Arenaviruses; Lassa fever virus; LCMV; Monkey models; Rhesus macaques; Viral hemorrhagic fever; 1 (5 chloro 1 naphthalenesulfonyl)hexahydro 1h 1,4 diazepine; 2 morpholino 8 phenylchromone; 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide; alanine aminotransferase; angiopeptin; antivirus agent; aspartate aminotransferase; bavituximab; benzimidazole; bryostatin; etanercept; f 100g 5; favipiravir; genistein; interleukin 6; isoniazid; lj 001; methyl beta cyclodextrin; monoclonal antibody; octreotide; ribavirin; rofecoxib; st 193; st 294; telmisartan; thalidomide; unclassified drug; antiviral activity; antiviral therapy; arenavirus infection; bleeding; blood clotting disorder; capillary leak syndrome; Chlorocebus; dehydration; erythema; gene expression; headache; heart arrest; histopathology; host; human; hypertransaminasemia; inflammatory infiltrate; influenza; Lassa fever; liver necrosis; lung edema; Lymphocytic choriomeningitis virus; lymphocytic infiltration; Macaca; Macaca mulatta; muscle stiffness; nausea; nonhuman; petechia; photophobia; priority journal; respiratory distress; review; rhesus monkey; seroprevalence; teratogenicity; third trimester pregnancy; thrombocytopenia; virus hemorrhagic fever; virus load; virus morphology; virus replication; virus titration; virus virulence; Animals; Arenaviridae Infections; Disease Models, Animal; Humans; Lassa Fever; Lymphocytic choriomeningitis virus; Macaca mulatta; Lassa virus; Lymphocytic choriomeningitis virus; Macaca; Macaca mulatta; Primates
Año:2011
Volumen:92
Número:2
Página de inicio:125
Página de fin:138
DOI: http://dx.doi.org/10.1016/j.antiviral.2011.07.015
Título revista:Antiviral Research
Título revista abreviado:Antiviral Res.
ISSN:01663542
CODEN:ARSRD
CAS:1 (5 chloro 1 naphthalenesulfonyl)hexahydro 1h 1,4 diazepine, 105637-50-1; 2 morpholino 8 phenylchromone, 154447-36-6; 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide, 146986-50-7; alanine aminotransferase, 9000-86-6, 9014-30-6; angiopeptin, 113294-82-9; aspartate aminotransferase, 9000-97-9; bavituximab, 648904-28-3; benzimidazole, 51-17-2; etanercept, 185243-69-0, 200013-86-1; favipiravir, 259793-96-9; genistein, 446-72-0; isoniazid, 54-85-3, 62229-51-0, 65979-32-0; octreotide, 83150-76-9; ribavirin, 36791-04-5; rofecoxib, 162011-90-7, 186912-82-3; telmisartan, 144701-48-4; thalidomide, 50-35-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01663542_v92_n2_p125_Zapata

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Citas:

---------- APA ----------
Zapata, J.C., Pauza, C.D., Djavani, M.M., Rodas, J.D., Moshkoff, D., Bryant, J., Ateh, E.,..., Salvato, M.S. (2011) . Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever. Antiviral Research, 92(2), 125-138.
http://dx.doi.org/10.1016/j.antiviral.2011.07.015
---------- CHICAGO ----------
Zapata, J.C., Pauza, C.D., Djavani, M.M., Rodas, J.D., Moshkoff, D., Bryant, J., et al. "Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever" . Antiviral Research 92, no. 2 (2011) : 125-138.
http://dx.doi.org/10.1016/j.antiviral.2011.07.015
---------- MLA ----------
Zapata, J.C., Pauza, C.D., Djavani, M.M., Rodas, J.D., Moshkoff, D., Bryant, J., et al. "Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever" . Antiviral Research, vol. 92, no. 2, 2011, pp. 125-138.
http://dx.doi.org/10.1016/j.antiviral.2011.07.015
---------- VANCOUVER ----------
Zapata, J.C., Pauza, C.D., Djavani, M.M., Rodas, J.D., Moshkoff, D., Bryant, J., et al. Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever. Antiviral Res. 2011;92(2):125-138.
http://dx.doi.org/10.1016/j.antiviral.2011.07.015