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Abstract:

The conventional therapy for the management of Herpes Simplex Virus Type 1 (HSV-1) infections mainly comprises acyclovir (ACV) and other nucleoside analogues. A common outcome of this treatment is the emergence of resistant viral strains, principally when immunosuppressed patients are involved. Thus, the development of new antiherpetic compounds remains as a central challenge. In this work we describe the synthesis and the in vitro antiherpetic activity of a new family of steroidal compounds derived from the endogenous hormone pregnenolone. Some of these derivatives showed a remarkable inhibitory effect on HSV-1 spread both on wild type and ACV-resistant strains. The results also show that these compounds seem to interfere with the late steps of the viral cycle. © 2015 Elsevier B.V.

Registro:

Documento: Artículo
Título:Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1
Autor:Dávola, M.E.; Mazaira, G.I.; Galigniana, M.D.; Alché, L.E.; Ramírez, J.A.; Barquero, A.A.
Filiación:CONICET - Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Piso 4 Ciudad Universitaria, Pabellón 2Buenos Aires C1428EGA, Argentina
Instituto de Biología y Medicina Experimental (IBYME), CONICET, Vuelta de Obligado 2490Buenos Aires C1428ADN, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Piso 4 Ciudad UniversitariaBuenos Aires C1428EGA, Argentina
Departamento de Química Orgánica and UMYMFOR, (CONICET - Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellón 2, Piso 3 Ciudad UniversitariaBuenos Aires C1428EGA, Argentina
Palabras clave:Acyclovir resistant; Antiviral; Herpes simplex type I; Non-natural side chains; Pregnenolone analogs; aciclovir; glucocorticoid; pregnenolone derivative; aciclovir; antivirus agent; pregnenolone; animal cell; antiviral activity; antiviral resistance; Article; controlled study; cytotoxicity; drug synthesis; Herpes simplex virus 1; nonhuman; priority journal; Vero cell line; virus isolation; virus strain; analogs and derivatives; animal; Chlorocebus aethiops; drug development; drug effects; growth, development and aging; herpes simplex; Herpes simplex virus 1; microbial sensitivity test; synthesis; Human herpesvirus 1; Acyclovir; Animals; Antiviral Agents; Cercopithecus aethiops; Drug Discovery; Drug Resistance, Viral; Herpes Simplex; Herpesvirus 1, Human; Microbial Sensitivity Tests; Pregnenolone; Vero Cells
Año:2015
Volumen:122
Página de inicio:55
Página de fin:63
DOI: http://dx.doi.org/10.1016/j.antiviral.2015.08.002
Título revista:Antiviral Research
Título revista abreviado:Antiviral Res.
ISSN:01663542
CODEN:ARSRD
CAS:aciclovir, 59277-89-3; pregnenolone, 145-13-1; Acyclovir; Antiviral Agents; Pregnenolone
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01663542_v122_n_p55_Davola

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Citas:

---------- APA ----------
Dávola, M.E., Mazaira, G.I., Galigniana, M.D., Alché, L.E., Ramírez, J.A. & Barquero, A.A. (2015) . Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1. Antiviral Research, 122, 55-63.
http://dx.doi.org/10.1016/j.antiviral.2015.08.002
---------- CHICAGO ----------
Dávola, M.E., Mazaira, G.I., Galigniana, M.D., Alché, L.E., Ramírez, J.A., Barquero, A.A. "Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1" . Antiviral Research 122 (2015) : 55-63.
http://dx.doi.org/10.1016/j.antiviral.2015.08.002
---------- MLA ----------
Dávola, M.E., Mazaira, G.I., Galigniana, M.D., Alché, L.E., Ramírez, J.A., Barquero, A.A. "Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1" . Antiviral Research, vol. 122, 2015, pp. 55-63.
http://dx.doi.org/10.1016/j.antiviral.2015.08.002
---------- VANCOUVER ----------
Dávola, M.E., Mazaira, G.I., Galigniana, M.D., Alché, L.E., Ramírez, J.A., Barquero, A.A. Synthetic pregnenolone derivatives as antiviral agents against acyclovir-resistant isolates of Herpes Simplex Virus Type 1. Antiviral Res. 2015;122:55-63.
http://dx.doi.org/10.1016/j.antiviral.2015.08.002