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Abstract:

Voltage-dependent calcium channels are essential in neuronal signaling and synaptic transmission, and their functional alterations underlie numerous human disorders whether monogenic (e.g., ataxia, migraine, etc.) or autoimmune. We review recent work on CaV2.1 or P/Q channelopathies, mostly using neuromuscular junction preparations, and focus specially on the functional hierarchy among the calcium channels recruited to mediate neurotransmitter release when CaV2.1 channels are mutated or depleted. In either case, synaptic transmission is greatly compromised; evidently, none of the reported functional replacements with other calcium channels compensates fully. © 2008 Elsevier B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Calcium channels, neuromuscular synaptic transmission and neurological diseases
Autor:Urbano, F.J.; Pagani, M.R.; Uchitel, O.D.
Filiación:Laboratorio de Fisiología y Biología Molecular, Instituto de Fisiología y Biología Molecular y Neurociencias, Universidad de Buenos Aires-CONICET, Pabellon 2, Piso 2, Ciudad Universitaria, C1428 Buenos Aires, Argentina
Palabras clave:Autoinmune Lambert-Eaton Syndrome; Calcium channels; Knock-in; Knock-out; L-type calcium channels; Neuromuscular junction; P/Q-type calcium channels; calcium channel cav2.1; calcium channel P type; calcium channel Q type; nifedipine; nitrendipine; unclassified drug; voltage gated calcium channel; Eaton Lambert syndrome; human; neurologic disease; neuromuscular synapse; neuromuscular transmission; nonhuman; priority journal; protein expression; protein function; protein protein interaction; review; synaptic transmission; Animals; Calcium Channels; Humans; Models, Biological; Models, Molecular; Nervous System Diseases; Neuromuscular Junction; Synaptic Transmission
Año:2008
Volumen:201-202
Número:C
Página de inicio:136
Página de fin:144
DOI: http://dx.doi.org/10.1016/j.jneuroim.2008.06.031
Título revista:Journal of Neuroimmunology
Título revista abreviado:J. Neuroimmunol.
ISSN:01655728
CODEN:JNRID
CAS:nifedipine, 21829-25-4; nitrendipine, 39562-70-4; Calcium Channels
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01655728_v201-202_nC_p136_Urbano

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Citas:

---------- APA ----------
Urbano, F.J., Pagani, M.R. & Uchitel, O.D. (2008) . Calcium channels, neuromuscular synaptic transmission and neurological diseases. Journal of Neuroimmunology, 201-202(C), 136-144.
http://dx.doi.org/10.1016/j.jneuroim.2008.06.031
---------- CHICAGO ----------
Urbano, F.J., Pagani, M.R., Uchitel, O.D. "Calcium channels, neuromuscular synaptic transmission and neurological diseases" . Journal of Neuroimmunology 201-202, no. C (2008) : 136-144.
http://dx.doi.org/10.1016/j.jneuroim.2008.06.031
---------- MLA ----------
Urbano, F.J., Pagani, M.R., Uchitel, O.D. "Calcium channels, neuromuscular synaptic transmission and neurological diseases" . Journal of Neuroimmunology, vol. 201-202, no. C, 2008, pp. 136-144.
http://dx.doi.org/10.1016/j.jneuroim.2008.06.031
---------- VANCOUVER ----------
Urbano, F.J., Pagani, M.R., Uchitel, O.D. Calcium channels, neuromuscular synaptic transmission and neurological diseases. J. Neuroimmunol. 2008;201-202(C):136-144.
http://dx.doi.org/10.1016/j.jneuroim.2008.06.031