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Abstract:

CD4+ T-cell lines (TCLs) from patients with clinically isolated syndromes (CIS) were selected with purified human myelin basic protein (MBP) and recombinant human myelin oligodendrocyte glycoprotein (rhMOG), at onset of neurological symptoms and when patients developed clinically definite multiple sclerosis (CDMS). The epitope specificity of each TCL was mapped with overlapping synthetic peptides. TCLs were assessed for their ability to secrete IFN-γ, IL-4, and IL-6. Diverse patterns of epitope recognition were observed: (a) recognition of a broad spectrum of MBP peptide epitopes with evidence of shifts over time; (b) an initial T-cell response focused to a restricted segment of the MBP molecule (83-102) that broadened over the course of disease; and (c) persistence of a focused anti-MOG T-cell response. CIS patients who failed to develop CDMS maintained a focused epitope response against two to six MBP epitopes. Most MBP peptide-specific TCLs secreted considerable amounts of IFN-γ and low amounts of IL-4 and IL-6, whereas anti rhMOGIgd peptide-specific TCLs secreted preferentially IL-4 and IL-6. These data raise important issues for the pathogenesis and treatment of multiple sclerosis (MS). © 2003 Elsevier Science B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Time course of T-cell responses to MOG and MBP in patients with clinically isolated syndromes
Autor:Correale, J.; Bassani Molinas, M.D.L.M.
Filiación:Department of Neurology, Raul Carrea Inst. Neurol. R., Montañeses 2325, Buenos Aires 1428, Argentina
Palabras clave:Autoimmunity; Clinically isolated syndromes; MBP; MOG; Multiple sclerosis; antibody; CD4 antigen; epitope; gamma interferon; interleukin 4; interleukin 6; myelin basic protein; myelin oligodendrocyte glycoprotein; adult; antigen recognition; article; cell line; clinical article; controlled study; cytokine release; disease course; female; human; male; multiple sclerosis; neurologic disease; onset age; priority journal; T lymphocyte
Año:2003
Volumen:136
Número:1-2
Página de inicio:162
Página de fin:171
DOI: http://dx.doi.org/10.1016/S0165-5728(03)00035-3
Título revista:Journal of Neuroimmunology
Título revista abreviado:J. Neuroimmunol.
ISSN:01655728
CODEN:JNRID
CAS:gamma interferon, 82115-62-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01655728_v136_n1-2_p162_Correale

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Citas:

---------- APA ----------
Correale, J. & Bassani Molinas, M.D.L.M. (2003) . Time course of T-cell responses to MOG and MBP in patients with clinically isolated syndromes. Journal of Neuroimmunology, 136(1-2), 162-171.
http://dx.doi.org/10.1016/S0165-5728(03)00035-3
---------- CHICAGO ----------
Correale, J., Bassani Molinas, M.D.L.M. "Time course of T-cell responses to MOG and MBP in patients with clinically isolated syndromes" . Journal of Neuroimmunology 136, no. 1-2 (2003) : 162-171.
http://dx.doi.org/10.1016/S0165-5728(03)00035-3
---------- MLA ----------
Correale, J., Bassani Molinas, M.D.L.M. "Time course of T-cell responses to MOG and MBP in patients with clinically isolated syndromes" . Journal of Neuroimmunology, vol. 136, no. 1-2, 2003, pp. 162-171.
http://dx.doi.org/10.1016/S0165-5728(03)00035-3
---------- VANCOUVER ----------
Correale, J., Bassani Molinas, M.D.L.M. Time course of T-cell responses to MOG and MBP in patients with clinically isolated syndromes. J. Neuroimmunol. 2003;136(1-2):162-171.
http://dx.doi.org/10.1016/S0165-5728(03)00035-3