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Abstract:

The autoimmune sialadenitis developed by non-obese diabetic (NOD) mice is considered a suitable model to study the ethiopathogenic mechanisms leading to sicca symptoms in Sjögren's syndrome (SS). Evidence supporting a neural rather than immune origin of the secretory dysfunction has been provided. As both nitric oxide and vasoactive intestinal peptide (VIP) are common messengers to nervous and immune systems mediating secretory and inflammatory responses, we examined nitric oxide synthase (NOS) activity with special focus on VIP-mediated effects in salivary glands of NOD mice. We found a decreased NOS activity and expression in major salivary glands of NOD mice with respect to control mice. In addition, there was a deficient VIP-activated signaling associated with a reduced saliva and amylase secretion in response to VIP. Our results support the hypothesis of an impaired balance of neuroimmune interactions in salivary glands as early events to take place in the progressive loss of secretory function of NOD mice. © 2002 Elsevier Science B.V. All rights reserved.

Registro:

Documento: Artículo
Título:Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice
Autor:Rosignoli, F.; Pérez Leirós, C.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina
Departamento de Qu, Ciudad Universitaria, Buenos Aires, Argentina
Palabras clave:Autoimmune sialadenitis; Nitric oxide; NOD mice; NOS isoforms; Salivary glands; VIP signaling; amylase; nitric oxide synthase; vasoactive intestinal polypeptide; amylase release; animal experiment; animal model; animal tissue; article; controlled study; diabetes mellitus; enzyme activation; enzyme activity; enzyme release; immune system; inflammation; mouse; nervous system; nonhuman; parotid gland; pathogenesis; priority journal; protein deficiency; protein expression; protein secretion; saliva level; salivation; sialoadenitis; signal transduction; Sjoegren syndrome; submandibular gland; Age Factors; Animals; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Neuroimmunomodulation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Parasympathetic Fibers, Postganglionic; Protein Isoforms; Receptors, Muscarinic; Saliva; Salivary Glands; Signal Transduction; Sjogren's Syndrome; Vasoactive Intestinal Peptide
Año:2002
Volumen:130
Número:1-2
Página de inicio:109
Página de fin:116
DOI: http://dx.doi.org/10.1016/S0165-5728(02)00223-0
Título revista:Journal of Neuroimmunology
Título revista abreviado:J. Neuroimmunol.
ISSN:01655728
CODEN:JNRID
CAS:Nitric Oxide Synthase Type I, EC 1.14.13.39; Nitric Oxide Synthase, EC 1.14.13.39; Nitric Oxide, 10102-43-9; Nos1 protein, mouse, EC 1.14.13.39; Protein Isoforms; Receptors, Muscarinic; Vasoactive Intestinal Peptide, 37221-79-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01655728_v130_n1-2_p109_Rosignoli

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Citas:

---------- APA ----------
Rosignoli, F. & Pérez Leirós, C. (2002) . Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice. Journal of Neuroimmunology, 130(1-2), 109-116.
http://dx.doi.org/10.1016/S0165-5728(02)00223-0
---------- CHICAGO ----------
Rosignoli, F., Pérez Leirós, C. "Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice" . Journal of Neuroimmunology 130, no. 1-2 (2002) : 109-116.
http://dx.doi.org/10.1016/S0165-5728(02)00223-0
---------- MLA ----------
Rosignoli, F., Pérez Leirós, C. "Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice" . Journal of Neuroimmunology, vol. 130, no. 1-2, 2002, pp. 109-116.
http://dx.doi.org/10.1016/S0165-5728(02)00223-0
---------- VANCOUVER ----------
Rosignoli, F., Pérez Leirós, C. Nitric oxide synthase I and VIP-activated signaling are affected in salivary glands of NOD mice. J. Neuroimmunol. 2002;130(1-2):109-116.
http://dx.doi.org/10.1016/S0165-5728(02)00223-0