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Abstract:

We focus on how the IL-1 system, T-helper1 (Th1) or Th2 cytokines and glucocorticoids, converge to give a unified physiological response. Glucocorticoids inhibit IL-1 and IL-1 receptor antagonist (IL-1ra) expression, Th1 cytokines stimulate both and Th2 cytokines stimulate IL-1ra and inhibit IL-1. Thus, during the Th1 response there is a window for IL-1 inflammatory activity, absent during the Th2 response. We also study the interactions among glucocorticoid and cytokine transcriptional activity. Glucocorticoids inhibit cytokine-induced transcription factors (NFkB, AP1) and cytokines enhance glucocorticoid receptor (GR) transcriptional activity, thus reciprocally fine tuning immunological control mechanisms. (C) 2000 Elsevier Science B.V.

Registro:

Documento: Artículo
Título:Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production
Autor:Kovalovsky, D.; Refojo, D.; Holsboer, F.; Arzt, E.
Filiación:Lab. de Fisiol. Y Biol. Molecular, Depto. Biol., FCEN, Univ. Buenos A., Buenos Aires, Argentina
CONICET, Buenos Aires, Argentina
Max-Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany
Palabras clave:Cytokines; Glucocorticoids; IL-1; IL-1ra; Th1; Th2; cytokine; gamma interferon; glucocorticoid; glucocorticoid receptor; hydrocortisone; immunoglobulin enhancer binding protein; interleukin 1; interleukin 1 receptor blocking agent; interleukin 10; interleukin 13; interleukin 2; interleukin 4; interleukin 5; lipopolysaccharide; lymphotoxin; STAT protein; transcription factor; transcription factor AP 1; transcription factor GATA 3; transforming growth factor beta; article; genetic transcription; hormonal regulation; human; hypothalamus hypophysis adrenal system; immune response; immune system; inflammation; priority journal; Animals; Glucocorticoids; Humans; Hypothalamo-Hypophyseal System; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Pituitary-Adrenal System; Sialoglycoproteins; Signal Transduction; Th1 Cells; Th2 Cells; Transcription, Genetic
Año:2000
Volumen:109
Número:1
Página de inicio:23
Página de fin:29
DOI: http://dx.doi.org/10.1016/S0165-5728(00)00298-8
Título revista:Journal of Neuroimmunology
Título revista abreviado:J. Neuroimmunol.
ISSN:01655728
CODEN:JNRID
CAS:Glucocorticoids; IL1RN protein, human; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Sialoglycoproteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01655728_v109_n1_p23_Kovalovsky

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Citas:

---------- APA ----------
Kovalovsky, D., Refojo, D., Holsboer, F. & Arzt, E. (2000) . Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production. Journal of Neuroimmunology, 109(1), 23-29.
http://dx.doi.org/10.1016/S0165-5728(00)00298-8
---------- CHICAGO ----------
Kovalovsky, D., Refojo, D., Holsboer, F., Arzt, E. "Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production" . Journal of Neuroimmunology 109, no. 1 (2000) : 23-29.
http://dx.doi.org/10.1016/S0165-5728(00)00298-8
---------- MLA ----------
Kovalovsky, D., Refojo, D., Holsboer, F., Arzt, E. "Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production" . Journal of Neuroimmunology, vol. 109, no. 1, 2000, pp. 23-29.
http://dx.doi.org/10.1016/S0165-5728(00)00298-8
---------- VANCOUVER ----------
Kovalovsky, D., Refojo, D., Holsboer, F., Arzt, E. Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production. J. Neuroimmunol. 2000;109(1):23-29.
http://dx.doi.org/10.1016/S0165-5728(00)00298-8