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Correale, J.; Lund, B.; McMillan, M.; Ko, D.Y.; McCarthy, K.; Weiner, L.P. "T cell vaccination in secondary progressive multiple sclerosis" (2000) Journal of Neuroimmunology. 107(2):130-139
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Abstract:

Four secondary progressive MS patients were vaccinated with bovine myelin-reactive irradiated T cell lines from their peripheral blood. Patients were followed for 30-39 months, and monitored for immunological responses toward the vaccine, and for their clinical characteristics. Two patients showed stable EDSS score over time, one patient showed improvement by one EDSS step, and in the remaining patient her EDSS advanced over time. After the second inoculation there was a progressive decline of circulating whole myelin-reactive T cells, MBP143-168, PLP104-117, and MOG43-55-peptide- reactive T cells. In contrast the frequency of tetanus toxoid-reactive T cells remained unchanged. T cell vaccination (TCV) was also associated with a decline of myelin-specific IL-2- and IFN-γ-secreting T cells. Twelve T cell lines (TCL) that recognize the inoculates were isolated from the peripheral blood of two patients. Ten of these TCL were CD8+ and lysed the inoculates in a MHC Class I restricted manner. The remaining two TCL were CD4+, and lysed the inoculates by MHC Class II restricted cytolytic activity. All T cell lines lysed not only myelin-reactive T cells, but also TCL specific for MBP143-168, PLP104-117 and MOG43-55 peptides. Control TCL specific for tetanus toxoid were not lysed. Neutralizing anti-Fas mAb did not influence the killing. Moreover, culture supernatants from two TCL which produce IL-10, were able to block the proliferation of myelin protein-specific TCL. This effect was abrogated using mAbs specific for IL-10. The data obtained indicated that TCV using autologous irradiated bovine myelin-reactive T cells promotes an effective depletion of T cells reactive against different myelin antigens. (C) 2000 Elsevier Science B.V.

Registro:

Documento: Artículo
Título:T cell vaccination in secondary progressive multiple sclerosis
Autor:Correale, J.; Lund, B.; McMillan, M.; Ko, D.Y.; McCarthy, K.; Weiner, L.P.
Filiación:Department of Neurology, USC Sch. Med., 1333 S. Pablo St., M., Los Angeles, CA 90033, United States
Dept. Molec. Microbiol. and Immunol., USC Sch. Med., 1333 S. Pablo St., M., Los Angeles, CA 90033, United States
Inst. Neurol. Res. 'Dr Raul C., Montañeses 2325 (1428), Buenos Aires, Argentina
Palabras clave:Lymphocytes; Multiple sclerosis; Myelin proteins; Vaccination; antibody specificity; antigen specificity; autoimmunity; conference paper; gene targeting; human; human cell; immune response; major histocompatibility complex restriction; molecular cloning; multiple sclerosis; oligodendroglia; priority journal; T lymphocyte activation; vaccination; Animals; Antibodies, Monoclonal; Antibody Formation; Cattle; CD8-Positive T-Lymphocytes; Cell Line; Disability Evaluation; Fas Ligand Protein; Humans; Interferon Type II; Membrane Glycoproteins; Multiple Sclerosis, Chronic Progressive; Myelin Proteins; Pilot Projects; Receptors, Antigen, T-Cell, alpha-beta; Species Specificity; Tumor Necrosis Factor-alpha; Vaccination
Año:2000
Volumen:107
Número:2
Página de inicio:130
Página de fin:139
DOI: http://dx.doi.org/10.1016/S0165-5728(00)00235-6
Título revista:Journal of Neuroimmunology
Título revista abreviado:J. Neuroimmunol.
ISSN:01655728
CODEN:JNRID
CAS:Antibodies, Monoclonal; Fas Ligand Protein; FASLG protein, human; Interferon Type II, 82115-62-6; Membrane Glycoproteins; Myelin Proteins; Receptors, Antigen, T-Cell, alpha-beta; Tumor Necrosis Factor-alpha
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01655728_v107_n2_p130_Correale

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Citas:

---------- APA ----------
Correale, J., Lund, B., McMillan, M., Ko, D.Y., McCarthy, K. & Weiner, L.P. (2000) . T cell vaccination in secondary progressive multiple sclerosis. Journal of Neuroimmunology, 107(2), 130-139.
http://dx.doi.org/10.1016/S0165-5728(00)00235-6
---------- CHICAGO ----------
Correale, J., Lund, B., McMillan, M., Ko, D.Y., McCarthy, K., Weiner, L.P. "T cell vaccination in secondary progressive multiple sclerosis" . Journal of Neuroimmunology 107, no. 2 (2000) : 130-139.
http://dx.doi.org/10.1016/S0165-5728(00)00235-6
---------- MLA ----------
Correale, J., Lund, B., McMillan, M., Ko, D.Y., McCarthy, K., Weiner, L.P. "T cell vaccination in secondary progressive multiple sclerosis" . Journal of Neuroimmunology, vol. 107, no. 2, 2000, pp. 130-139.
http://dx.doi.org/10.1016/S0165-5728(00)00235-6
---------- VANCOUVER ----------
Correale, J., Lund, B., McMillan, M., Ko, D.Y., McCarthy, K., Weiner, L.P. T cell vaccination in secondary progressive multiple sclerosis. J. Neuroimmunol. 2000;107(2):130-139.
http://dx.doi.org/10.1016/S0165-5728(00)00235-6