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Abstract:

The presence of cellular reactivity against homologous tissues and subcellular fractions of Trypanosoma cruzi was investigated in Chagas' disease patients (CDP). CDP were grouped in asymptomatic (CDP-1) and with probable (CDP-2) and overt (CDP-3) cardiomyopathy. Healthy and non-Chagasic cardiomyopathic subjects were studied as controls. Lymphoproliferative reactions against heart tissue extracts were detected in 42% of 72 CDP studied, with similar prevalence of positive reactions in all groups, and correlated with reactivity to both liver and kidney homologous tissues (P<0.001). These results confirm the existence of cellular immune reactivity against tissues in CDP, and indicate the lack of organ specificity of this reaction as well as the absence of relation with the clinical state of patients. Cellular reactivity to subcellular fractions of T. cruzi showed a definite pattern according to the clinical status of CDP. Although prevalence of T. cruzi stimulation appeared similar in all groups (70% in CDP-1, 82% in CDP-2 and 75% in CDP-3), CDP-3 showed a significantly higher reactivity to flagellar (69%) and cytosol (63%) fractions than CDP-1 (38 and 27%, respectively). These findings suggest a variable modulation of immune response according to the clinical state of T. cruzi infected subjects. © 1985.

Registro:

Documento: Artículo
Título:Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients
Autor:De Titto, E.H.; Braun, M.; Lazzari, J.O.; Segura, E.L.
Filiación:Instituto Nacional de Diagnostico e Investigacion de la Enfermedad de Chagas' Dr. Mario Fatala Chaben (INDIECH), Ministerio de Salud y Accion Social, Av. Paseo Colon 568, (1063) Buenos Aires, Argentina, Argentina
Division de Inmunofarmacologia, Centro de Estudios Farmacologicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Serrano 665, 1414 Buenos Aires, Argentina
Servicio de Cardiologia, Hospital Ramos Mejia, Municipalidad la Ciudad Buenos Aires, Urquiza 609, 1221 Buenos Aires, Argentina
Palabras clave:cell-mediated immunity subcellular antigens; Chagas' disease; heart antigens; T. cruzi; blood and hemopoietic system; cardiomyopathy; cellular immunity; chagas disease; diagnosis; etiology; heart; human; human cell; human experiment; priority journal; protozoon; trypanosoma cruzi antigen; Adolescent; Adult; Aged; Antigens, Protozoan; Chagas Disease; Comparative Study; Female; Human; Immunity, Cellular; In Vitro; Isoantigens; Lymphocyte Activation; Male; Middle Age; Myocardium; Subcellular Fractions; Support, Non-U.S. Gov't; Trypanosoma cruzi
Año:1985
Volumen:9
Número:5
Página de inicio:249
Página de fin:254
DOI: http://dx.doi.org/10.1016/0165-2478(85)90002-1
Título revista:Immunology Letters
Título revista abreviado:Immunol. Lett.
ISSN:01652478
CODEN:IMLED
CAS:Antigens, Protozoan; Isoantigens
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01652478_v9_n5_p249_DeTitto

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Citas:

---------- APA ----------
De Titto, E.H., Braun, M., Lazzari, J.O. & Segura, E.L. (1985) . Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients. Immunology Letters, 9(5), 249-254.
http://dx.doi.org/10.1016/0165-2478(85)90002-1
---------- CHICAGO ----------
De Titto, E.H., Braun, M., Lazzari, J.O., Segura, E.L. "Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients" . Immunology Letters 9, no. 5 (1985) : 249-254.
http://dx.doi.org/10.1016/0165-2478(85)90002-1
---------- MLA ----------
De Titto, E.H., Braun, M., Lazzari, J.O., Segura, E.L. "Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients" . Immunology Letters, vol. 9, no. 5, 1985, pp. 249-254.
http://dx.doi.org/10.1016/0165-2478(85)90002-1
---------- VANCOUVER ----------
De Titto, E.H., Braun, M., Lazzari, J.O., Segura, E.L. Cell-mediated reactivity against human and Trypanosoma cruzi antigens according to clinical status in Chagas' disease patients. Immunol. Lett. 1985;9(5):249-254.
http://dx.doi.org/10.1016/0165-2478(85)90002-1