Artículo
Roldan, A.; Charreau, E.; Schillaci, R.; Eugui, E.M.; Allison, A.C. "Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin" (1989) Immunology Letters. 20(1):5-8
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Abstract:
Receptors for insulin and insulin-like growth factor-1 (IGF-1) have been demonstrated on activated T-lymphocytes. The question is whether receptors for insulin or IGF-1 have any function in these cells. In this study we demonstrate that the concentration of IGF-1 in commercial samples of fetal calf serum is about 70 times that of insuli. Moreover, antibodies of IGF-1 reduce responses of human peripheral blood mononuclear cells to PHA by about 50% whereas antibodies to insulin have no demonstrable effect. These observations suggest that binding of IGF-1 to specific receptors contributes to the proliferative responses of activated T-lymphocytes. © 1989.
Registro:
| Documento: | Artículo |
| Título: | Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin |
| Autor: | Roldan, A.; Charreau, E.; Schillaci, R.; Eugui, E.M.; Allison, A.C. |
| Filiación: | Instituto de Biologia y Medicina Experimental, Obligado 2490, 1428 Buenos Aires, Argentina Department of Immunology, Institute of Biological Sciences, Syntex Research, Palo Alto, CA, United States |
| Palabras clave: | Fetal calf serum; Human peripheral blood mononuclear cells; Insulin-like growth factor-1 (IGF-1); Mitogenic response; growth factor; insulin; mitogenic agent; phytohemagglutinin; cell culture; human; human cell; normal human; peripheral lymphocyte; priority journal; t lymphocyte; Animal; Antibodies; Cattle; Cell Division; Fetal Blood; Human; Insulin-Like Growth Factor I; Lymphocyte Activation; Phytohemagglutinins; Receptors, Cell Surface; Receptors, Somatomedin; Recombinant Proteins; Somatomedins; Stimulation, Chemical; Support, Non-U.S. Gov't; T-Lymphocytes |
| Año: | 1989 |
| Volumen: | 20 |
| Número: | 1 |
| Página de inicio: | 5 |
| Página de fin: | 8 |
| DOI: | http://dx.doi.org/10.1016/0165-2478(89)90060-6 |
| Título revista: | Immunology Letters |
| Título revista abreviado: | Immunol. Lett. |
| ISSN: | 01652478 |
| CODEN: | IMLED |
| CAS: | insulin, 9004-10-8; phytohemagglutinin, 9008-97-3; Antibodies; Insulin-Like Growth Factor I, 67763-96-6; Phytohemagglutinins; Receptors, Cell Surface; Receptors, Somatomedin; Recombinant Proteins; Somatomedins |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01652478_v20_n1_p5_Roldan |
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Citas:
---------- APA ----------
Roldan, A., Charreau, E., Schillaci, R., Eugui, E.M. & Allison, A.C. (1989) . Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin. Immunology Letters, 20(1), 5-8.http://dx.doi.org/10.1016/0165-2478(89)90060-6
---------- CHICAGO ----------
Roldan, A., Charreau, E., Schillaci, R., Eugui, E.M., Allison, A.C. "Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin" . Immunology Letters 20, no. 1 (1989) : 5-8.http://dx.doi.org/10.1016/0165-2478(89)90060-6
---------- MLA ----------
Roldan, A., Charreau, E., Schillaci, R., Eugui, E.M., Allison, A.C. "Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin" . Immunology Letters, vol. 20, no. 1, 1989, pp. 5-8.http://dx.doi.org/10.1016/0165-2478(89)90060-6
---------- VANCOUVER ----------
Roldan, A., Charreau, E., Schillaci, R., Eugui, E.M., Allison, A.C. Insulin-like growth factor-1 increases the mitogenic response of human peripheral blood lymphocytes to phytohemagglutinin. Immunol. Lett. 1989;20(1):5-8.http://dx.doi.org/10.1016/0165-2478(89)90060-6
