Artículo
Rojo De Almeida, M.T.; Siless, G.E.; Perez, C.D.; Veloso, M.J.; Schejter, L.; Puricelli, L.; Palermo, J.A. "Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica" (2010) Journal of Natural Products. 73(10):1714-1717
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Abstract:
Two new dolabellane diterpenoids (1 and 2) were isolated from a small sample of the deep water gorgonian octocoral Convexella magelhaenica collected as a nontarget by-catch by dredging (-93 m) in commercial Patagonian scallop fishing grounds in the South Atlantic. The structures of the new compounds, which are major metabolites in the extract, were established by spectroscopic techniques and chemical transformations. Both compounds were cytotoxic against a human pancreatic adenocarcinoma cell line at micromolar concentrations. © 2010 The American Chemical Society and American Society of Pharmacognosy.
Registro:
| Documento: | Artículo |
| Título: | Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica |
| Autor: | Rojo De Almeida, M.T.; Siless, G.E.; Perez, C.D.; Veloso, M.J.; Schejter, L.; Puricelli, L.; Palermo, J.A. |
| Filiación: | UMYMFOR, Departamento de Química Orgánica, Universidad de Buenos Aires, Pabellón 2, (1428), Buenos Aires, Argentina Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Campus Trindade, 88040-970 Florianópolis, SC, Brazil Nucleo de Biologia, Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Rua do Alto do Reservatório s/n, Bela Vista CEP 55608-680, Vitoria de Santo Antao/PE, Brazil Research Area, Angel H. Roffo Institute of Oncology, University of Buenos Aires, Avenida San Martín 5481, (C1417DTB), Buenos Aires, Argentina Laboratorio de Bentos, Instituto Nacional de Investigación y Desarrollo Pesquero, Paseo Victoria Ocampo 1, (B7602HSA), Mar del Plata, Argentina |
| Palabras clave: | 2,13 diacetoxydolabella 3,7,18 trien 9 one; Convexella magelhaenica extract; diterpenoid; dolabella 3,7,18 trien 9 one; dolabellane diterpenoid derivative; plant extract; unclassified drug; (1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one; (1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one; diterpene; dolabellane; animal cell; article; cancer cell culture; concentration response; Convexella magelhaenica; coral; drug cytotoxicity; drug isolation; human; human cell; IC 50; mouse; nonhuman; pancreas adenocarcinoma; adenocarcinoma; animal; Anthozoa; Atlantic Ocean; chemical structure; chemistry; isolation and purification; nuclear magnetic resonance; Pancreatic Neoplasms; Gorgonia; Adenocarcinoma; Animals; Anthozoa; Atlantic Ocean; Diterpenes; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pancreatic Neoplasms |
| Año: | 2010 |
| Volumen: | 73 |
| Número: | 10 |
| Página de inicio: | 1714 |
| Página de fin: | 1717 |
| DOI: | http://dx.doi.org/10.1021/np100337j |
| Título revista: | Journal of Natural Products |
| Título revista abreviado: | J. Nat. Prod. |
| ISSN: | 01633864 |
| CODEN: | JNPRD |
| CAS: | (1R,3E,7E,11S,12R)-dolabella-3,7,18-trien-9-one; (1S,2R,3E,7E,11S,12R,13S)-2,13-diacetoxydolabella-3,7,18-trien-9-one; Diterpenes; dolabellane |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v73_n10_p1714_RojoDeAlmeida |
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Citas:
---------- APA ----------
Rojo De Almeida, M.T., Siless, G.E., Perez, C.D., Veloso, M.J., Schejter, L., Puricelli, L. & Palermo, J.A. (2010) . Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica. Journal of Natural Products, 73(10), 1714-1717.http://dx.doi.org/10.1021/np100337j
---------- CHICAGO ----------
Rojo De Almeida, M.T., Siless, G.E., Perez, C.D., Veloso, M.J., Schejter, L., Puricelli, L., et al. "Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica" . Journal of Natural Products 73, no. 10 (2010) : 1714-1717.http://dx.doi.org/10.1021/np100337j
---------- MLA ----------
Rojo De Almeida, M.T., Siless, G.E., Perez, C.D., Veloso, M.J., Schejter, L., Puricelli, L., et al. "Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica" . Journal of Natural Products, vol. 73, no. 10, 2010, pp. 1714-1717.http://dx.doi.org/10.1021/np100337j
---------- VANCOUVER ----------
Rojo De Almeida, M.T., Siless, G.E., Perez, C.D., Veloso, M.J., Schejter, L., Puricelli, L., et al. Dolabellane diterpenoids from the south atlantic gorgonian convexella magelhaenica. J. Nat. Prod. 2010;73(10):1714-1717.http://dx.doi.org/10.1021/np100337j
