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Abstract:

Two new sulfated polyhydroxylated steroidal xylosides, minutosides A (1) and B (2), together with the known pycnopodioside B (3), have been isolated from the brine shrimp active fraction of the ethanolic extract of the starfish Anasterias minuta. The structures have been elucidated by extensive 1D and 2D NMR as well as FABMS analysis and chemical methods. Compound 2 is the first example of a polyhydroxylated steroidal xyloside containing an amide function in the aglycon side chain. The three xylosides exhibited antifungal activity against Cladosporium cucumerinum and Aspergillus flavus. © 2005 American Chemical Society and American Society of Pharmacognosy.

Registro:

Documento: Artículo
Título:Minutosides A and B, antifungal sulfated steroid xylosides from the patagonian starfish Anasterias minuta
Autor:Chludil, H.D.; Maier, M.S.
Filiación:Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:antifungal agent; benomyl; minutoside A; minutoside B; pycnopodioside A; pycnopodioside B; steroid; unclassified drug; xyloside derivative; Anasterias minuta; antifungal activity; article; Aspergillus flavus; Asterias; carbon nuclear magnetic resonance; Cladosporium cucumerinum; controlled study; drug hydroxylation; drug isolation; drug structure; drug sulfation; fast atom bombardment mass spectrometry; minimum inhibitory concentration; nonhuman; nuclear magnetic resonance spectroscopy; nuclear Overhauser effect; proton nuclear magnetic resonance; structure analysis; Animals; Antifungal Agents; Argentina; Aspergillus flavus; Cladosporium; Glycosides; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Starfish; Steroids; Sulfuric Acid Esters; Anostraca; Aspergillus flavus; Asteroidea; Cladosporium cucumerinum
Año:2005
Volumen:68
Número:8
Página de inicio:1279
Página de fin:1283
DOI: http://dx.doi.org/10.1021/np050086f
Título revista:Journal of Natural Products
Título revista abreviado:J. Nat. Prod.
ISSN:01633864
CODEN:JNPRD
CAS:benomyl, 17804-35-2; Antifungal Agents; Glycosides; minutoside A; minutoside B; Steroids; Sulfuric Acid Esters
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v68_n8_p1279_Chludil

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Citas:

---------- APA ----------
Chludil, H.D. & Maier, M.S. (2005) . Minutosides A and B, antifungal sulfated steroid xylosides from the patagonian starfish Anasterias minuta. Journal of Natural Products, 68(8), 1279-1283.
http://dx.doi.org/10.1021/np050086f
---------- CHICAGO ----------
Chludil, H.D., Maier, M.S. "Minutosides A and B, antifungal sulfated steroid xylosides from the patagonian starfish Anasterias minuta" . Journal of Natural Products 68, no. 8 (2005) : 1279-1283.
http://dx.doi.org/10.1021/np050086f
---------- MLA ----------
Chludil, H.D., Maier, M.S. "Minutosides A and B, antifungal sulfated steroid xylosides from the patagonian starfish Anasterias minuta" . Journal of Natural Products, vol. 68, no. 8, 2005, pp. 1279-1283.
http://dx.doi.org/10.1021/np050086f
---------- VANCOUVER ----------
Chludil, H.D., Maier, M.S. Minutosides A and B, antifungal sulfated steroid xylosides from the patagonian starfish Anasterias minuta. J. Nat. Prod. 2005;68(8):1279-1283.
http://dx.doi.org/10.1021/np050086f