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Abstract:

In addition to the known mutisicoumaranones A (1) and B (2), the methanolic extract of the aerial parts of the shrub Mutisia friesiana afforded two new 5-methylcoumaranones, mutisicoumaranones C (3) and D (4). Their structures were elucidated by spectroscopic methods. 13C NMR data for mutisicoumaranones A and B are reported for the first time. All compounds showed antifungal activity against the phytopathogenic fungus Cladosporium cucumerinum and bactericidal activity against Staphylococcus aureus. The presence of 5-methylcoumaranones A-D is biosynthetically related to 5-methylcoumarins and phenolic derivatives previously isolated from M. friesiana.

Registro:

Documento: Artículo
Título:5-Methylcoumaranones from Mutisia friesiana and their bioactivity
Autor:Viturro, C.I.; De La Fuente, J.R.; Maier, M.S.
Filiación:Facultad de Ingeniería, Universidad Nacional de Jujuy, Gorriti 237, 4600 S. S. de Jujuy, Jujuy, Argentina
Facultad de Ciencias Exactas, Universidad Nacional de Salta, 4400 Salta, Salta, Argentina
Departamento de Quimica Organica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Palabras clave:5 methylcoumaranone; 5 methylcoumaranone a; 5 methylcoumaranone b; 5 methylcoumaranone c; 5 methylcoumaranone d; mutisicoumaranone a; mutisicoumaranone b; mutisicoumaranone c; mutisicoumaranone d; plant extract; unclassified drug; antifungal activity; article; bactericidal activity; carbon nuclear magnetic resonance; chemical structure; Cladosporium cucumerinum; drug activity; Mutisia friesiana; plant; proton nuclear magnetic resonance; spectroscopy; Staphylococcus aureus; structure analysis; woody stem; Antibiotics, Antifungal; Antifungal Agents; Argentina; Asteraceae; Benzofurans; Cladosporium; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Staphylococcus aureus; Cladosporium; Cladosporium cucumerinum; Fungi; Mutisia; Staphylococcus; Staphylococcus aureus
Año:2004
Volumen:67
Número:5
Página de inicio:778
Página de fin:782
DOI: http://dx.doi.org/10.1021/np0304058
Título revista:Journal of Natural Products
Título revista abreviado:J. Nat. Prod.
ISSN:01633864
CODEN:JNPRD
CAS:Antibiotics, Antifungal; Antifungal Agents; Benzofurans
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v67_n5_p778_Viturro

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Citas:

---------- APA ----------
Viturro, C.I., De La Fuente, J.R. & Maier, M.S. (2004) . 5-Methylcoumaranones from Mutisia friesiana and their bioactivity. Journal of Natural Products, 67(5), 778-782.
http://dx.doi.org/10.1021/np0304058
---------- CHICAGO ----------
Viturro, C.I., De La Fuente, J.R., Maier, M.S. "5-Methylcoumaranones from Mutisia friesiana and their bioactivity" . Journal of Natural Products 67, no. 5 (2004) : 778-782.
http://dx.doi.org/10.1021/np0304058
---------- MLA ----------
Viturro, C.I., De La Fuente, J.R., Maier, M.S. "5-Methylcoumaranones from Mutisia friesiana and their bioactivity" . Journal of Natural Products, vol. 67, no. 5, 2004, pp. 778-782.
http://dx.doi.org/10.1021/np0304058
---------- VANCOUVER ----------
Viturro, C.I., De La Fuente, J.R., Maier, M.S. 5-Methylcoumaranones from Mutisia friesiana and their bioactivity. J. Nat. Prod. 2004;67(5):778-782.
http://dx.doi.org/10.1021/np0304058