Abstract:
In addition to the known mutisicoumaranones A (1) and B (2), the methanolic extract of the aerial parts of the shrub Mutisia friesiana afforded two new 5-methylcoumaranones, mutisicoumaranones C (3) and D (4). Their structures were elucidated by spectroscopic methods. 13C NMR data for mutisicoumaranones A and B are reported for the first time. All compounds showed antifungal activity against the phytopathogenic fungus Cladosporium cucumerinum and bactericidal activity against Staphylococcus aureus. The presence of 5-methylcoumaranones A-D is biosynthetically related to 5-methylcoumarins and phenolic derivatives previously isolated from M. friesiana.
Registro:
Documento: |
Artículo
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Título: | 5-Methylcoumaranones from Mutisia friesiana and their bioactivity |
Autor: | Viturro, C.I.; De La Fuente, J.R.; Maier, M.S. |
Filiación: | Facultad de Ingeniería, Universidad Nacional de Jujuy, Gorriti 237, 4600 S. S. de Jujuy, Jujuy, Argentina Facultad de Ciencias Exactas, Universidad Nacional de Salta, 4400 Salta, Salta, Argentina Departamento de Quimica Organica, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
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Palabras clave: | 5 methylcoumaranone; 5 methylcoumaranone a; 5 methylcoumaranone b; 5 methylcoumaranone c; 5 methylcoumaranone d; mutisicoumaranone a; mutisicoumaranone b; mutisicoumaranone c; mutisicoumaranone d; plant extract; unclassified drug; antifungal activity; article; bactericidal activity; carbon nuclear magnetic resonance; chemical structure; Cladosporium cucumerinum; drug activity; Mutisia friesiana; plant; proton nuclear magnetic resonance; spectroscopy; Staphylococcus aureus; structure analysis; woody stem; Antibiotics, Antifungal; Antifungal Agents; Argentina; Asteraceae; Benzofurans; Cladosporium; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Staphylococcus aureus; Cladosporium; Cladosporium cucumerinum; Fungi; Mutisia; Staphylococcus; Staphylococcus aureus |
Año: | 2004
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Volumen: | 67
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Número: | 5
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Página de inicio: | 778
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Página de fin: | 782
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DOI: |
http://dx.doi.org/10.1021/np0304058 |
Título revista: | Journal of Natural Products
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Título revista abreviado: | J. Nat. Prod.
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ISSN: | 01633864
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CODEN: | JNPRD
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CAS: | Antibiotics, Antifungal; Antifungal Agents; Benzofurans
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v67_n5_p778_Viturro |
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Citas:
---------- APA ----------
Viturro, C.I., De La Fuente, J.R. & Maier, M.S.
(2004)
. 5-Methylcoumaranones from Mutisia friesiana and their bioactivity. Journal of Natural Products, 67(5), 778-782.
http://dx.doi.org/10.1021/np0304058---------- CHICAGO ----------
Viturro, C.I., De La Fuente, J.R., Maier, M.S.
"5-Methylcoumaranones from Mutisia friesiana and their bioactivity"
. Journal of Natural Products 67, no. 5
(2004) : 778-782.
http://dx.doi.org/10.1021/np0304058---------- MLA ----------
Viturro, C.I., De La Fuente, J.R., Maier, M.S.
"5-Methylcoumaranones from Mutisia friesiana and their bioactivity"
. Journal of Natural Products, vol. 67, no. 5, 2004, pp. 778-782.
http://dx.doi.org/10.1021/np0304058---------- VANCOUVER ----------
Viturro, C.I., De La Fuente, J.R., Maier, M.S. 5-Methylcoumaranones from Mutisia friesiana and their bioactivity. J. Nat. Prod. 2004;67(5):778-782.
http://dx.doi.org/10.1021/np0304058