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Misico, R.I.; Gil, R.R.; Oberti, J.C.; Veleiro, A.S.; Burton, G. "Withanolides from Vassobia lorentzii" (2000) Journal of Natural Products. 63(10):1329-1332
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Abstract:

Eight new withanolides were isolated from the aerial parts of Vassobia lorentzii and characterized by spectroscopic methods and with the aid of molecular modeling. The compounds were identified as (17S,20R,22R)-5β,6β:18,20-diepoxy-18-hydroxy-1-oxowitha-2,5,24-trienolide (1); (17S,20R,22R)-18,20-epoxy-4β,18-dihydroxy-1-oxowitha-2,5,24-trienolide (2); (17S,18R,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trieno lide (3); (17S,18S,20R,22R)-4β-hydroxy-18,20-epoxy-18-methoxy-1-oxowitha-2,5,24-trieno lide (4); (17S,20R,22R)-4β-hydroxy-18,20-epoxy-1,18-dioxowitha-2,5,24-trienolide (5); (17S,18R,20R,22R)-18,20-epoxy-18-methoxy-1,4-dioxowitha-2,5,24-trienolide (6); (17S,18S,20R,22R)-18,20-epoxy-18-methoxy-1,4-dioxowitha-2,5,24-trienolide (7); and (17S,20R,22R)-5β,6β-epoxy-4β,18,20-trihydroxy-1-oxowitha-2,24-dienolide (8). Compounds 1 and 2 were obtained as epimeric mixtures at C-18.

Registro:

Documento: Artículo
Título:Withanolides from Vassobia lorentzii
Autor:Misico, R.I.; Gil, R.R.; Oberti, J.C.; Veleiro, A.S.; Burton, G.
Filiación:Departamento de Química Orgánica and IMBIV, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, 5000 Córdoba, Argentina
Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:18,20 epoxy 18 methoxy 1,4 dioxowitha 2,5,24 trienolide; 18,20 epoxy 4beta,18 dihydroxy 1 oxowitha 2,5,24 trienolide; 4beta hydroxy 18,20 epoxy 1,18 dioxowitha 2,5,24 trienolide; 4beta hydroxy 18,20 epoxy 18 methoxy 1 oxowitha 2,5,24 trienolide; 5beta,6beta epoxy 4beta,18,20 trihydroxy 1 oxowitha 2,24 dienolide; 5beta,6beta:18,20 diepoxy 18 hydroxy 1 oxowitha 2,5,24 trienolide; plant extract; unclassified drug; Vassobia lorentzii extract; withanolide; article; chemical structure; chemotaxonomy; extraction; isomer; molecular model; nonhuman; spectroscopy; Animals; Antimalarials; Ergosterol; Humans; Lactones; Magnetic Resonance Spectroscopy; Plasmodium falciparum; Solanaceae; Vassobia
Año:2000
Volumen:63
Número:10
Página de inicio:1329
Página de fin:1332
DOI: http://dx.doi.org/10.1021/np000022z
Título revista:Journal of Natural Products
Título revista abreviado:J. Nat. Prod.
ISSN:01633864
CODEN:JNPRD
CAS:withanolide, 40326-62-3; Antimalarials; Ergosterol, 57-87-4; Lactones
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v63_n10_p1329_Misico

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Citas:

---------- APA ----------
Misico, R.I., Gil, R.R., Oberti, J.C., Veleiro, A.S. & Burton, G. (2000) . Withanolides from Vassobia lorentzii. Journal of Natural Products, 63(10), 1329-1332.
http://dx.doi.org/10.1021/np000022z
---------- CHICAGO ----------
Misico, R.I., Gil, R.R., Oberti, J.C., Veleiro, A.S., Burton, G. "Withanolides from Vassobia lorentzii" . Journal of Natural Products 63, no. 10 (2000) : 1329-1332.
http://dx.doi.org/10.1021/np000022z
---------- MLA ----------
Misico, R.I., Gil, R.R., Oberti, J.C., Veleiro, A.S., Burton, G. "Withanolides from Vassobia lorentzii" . Journal of Natural Products, vol. 63, no. 10, 2000, pp. 1329-1332.
http://dx.doi.org/10.1021/np000022z
---------- VANCOUVER ----------
Misico, R.I., Gil, R.R., Oberti, J.C., Veleiro, A.S., Burton, G. Withanolides from Vassobia lorentzii. J. Nat. Prod. 2000;63(10):1329-1332.
http://dx.doi.org/10.1021/np000022z