Three new and two known sulfated steroidal polyols have been isolated from the Antarctic ophiuroid Astrotoma agassizii. All of the new steroids possess a terminal isopropenyl group and a C-21 sulfoxy moiety in the side chain but differ in the steroidal nuclei. The structures of these new steroids were established from spectral and chemical correlations with related steroids as (20R)-cholesta-5,24-diene-2β,3α,21-triol 2,21-disulfate (1), (20R)-5α-cholest-24-ene-2β,3α,21-triol 3,21-disulfate (3), and (20R)- cholesta-5,24-diene-2α,3α,4β,21-tetrol 3,21-disulfate (5). Analysis of the nonsulfated sterol fraction has shown the presence of cholest-5-en-3β-ol, cholesta-5,24-dien-3β-ol and (22E) cholesta-5,22-dien-3β-ol as the major sterols.
Documento: | Artículo |
Título: | New sulfated polyhydroxysteroids from the Antarctic ophiuroid Astrotoma agassizii |
Autor: | Roccatagliata, A.J.; Maier, M.S.; Seldes, A.M. |
Filiación: | Departamento de Quimica Organica, Fac. de Ciencias Exactas y Naturales, Pabellon 2, 1428 Buenos Aires, Argentina |
Palabras clave: | 5alpha cholest 24 ene 2beta,3alpha,21 triol 3,21 disulfate; cholesta 5,24 diene 2alpha,3alpha,4beta,21 tetrol 3,21 disulfate; cholesta 5,24 diene 2beta,3alpha,21 triol 2,21 disulfate; cholesterol; hydroxysteroid; sterol; unclassified drug; article; chemical analysis; column chromatography; data analysis; drug isolation; enzyme activity; high performance liquid chromatography; nuclear magnetic resonance; sulfation; Astrotoma agassizii |
Año: | 1998 |
Volumen: | 61 |
Número: | 3 |
Página de inicio: | 370 |
Página de fin: | 374 |
DOI: | http://dx.doi.org/10.1021/np970429c |
Título revista: | Journal of Natural Products |
Título revista abreviado: | J. Nat. Prod. |
ISSN: | 01633864 |
CODEN: | JNPRD |
CAS: | cholesterol, 57-88-5 |
Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v61_n3_p370_Roccatagliata |