Abstract:
From the leaves of Salpichroa origanifolia three new withanolides, (20S,22R,24S,25S,26R)-5α,6α:22,26:24,25-triepoxy-15,26-dihydroxy- 17(13→18)-abeo-ergosta-2,13,15,17-tetraen-1-one (salpichrolide G, 1), (20S,22R,24S,25R)-5α,6α:22,26-diepoxy-24,25,26-trihydroxy-17(13→18)-abeo- ergosta-2,13,15,17-tetraen-1-one (salpichrolide H, 2), and (20S,22R,25S)- 5α,6α:22,26-diepoxy-25,26-dihydroxy-17(13→18)-abeo-ergosta-2,13,15,17,23- pentaen-1-one (salpichrolide I, 3), were isolated and characterized by spectroscopic methods and with the aid of molecular modeling. The latter two compounds were obtained as an epimeric mixture at C-26.
Registro:
Documento: |
Artículo
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Título: | New hydroxylated withanolides from Salpichroa origanifolia |
Autor: | Tettamanzi, M.C.; Veleiro, A.S.; Oberti, J.C.; Burton, G. |
Filiación: | Depto. de Quim. Orgánica, Pabellón 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina Depto. de Quim. Orgánica, Facultad de Ciencias Químicas, Univ. Nacional de Córdoba, Ap. Postal 4, Casilla 61, 5000 Córdoba, Argentina
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Palabras clave: | salpichrolide g; salpichrolide h; salpichrolide i; unclassified drug; withanolide; article; carbon nuclear magnetic resonance; chemical structure; hydroxylation; molecular model; nuclear Overhauser effect; plant leaf; proton nuclear magnetic resonance; spectroscopy; stereochemistry; Salpichroa origanifolia |
Año: | 1998
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Volumen: | 61
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Número: | 3
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Página de inicio: | 338
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Página de fin: | 342
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DOI: |
http://dx.doi.org/10.1021/np970387s |
Título revista: | Journal of Natural Products
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Título revista abreviado: | J. Nat. Prod.
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ISSN: | 01633864
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CODEN: | JNPRD
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CAS: | withanolide, 40326-62-3
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v61_n3_p338_Tettamanzi |
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Citas:
---------- APA ----------
Tettamanzi, M.C., Veleiro, A.S., Oberti, J.C. & Burton, G.
(1998)
. New hydroxylated withanolides from Salpichroa origanifolia. Journal of Natural Products, 61(3), 338-342.
http://dx.doi.org/10.1021/np970387s---------- CHICAGO ----------
Tettamanzi, M.C., Veleiro, A.S., Oberti, J.C., Burton, G.
"New hydroxylated withanolides from Salpichroa origanifolia"
. Journal of Natural Products 61, no. 3
(1998) : 338-342.
http://dx.doi.org/10.1021/np970387s---------- MLA ----------
Tettamanzi, M.C., Veleiro, A.S., Oberti, J.C., Burton, G.
"New hydroxylated withanolides from Salpichroa origanifolia"
. Journal of Natural Products, vol. 61, no. 3, 1998, pp. 338-342.
http://dx.doi.org/10.1021/np970387s---------- VANCOUVER ----------
Tettamanzi, M.C., Veleiro, A.S., Oberti, J.C., Burton, G. New hydroxylated withanolides from Salpichroa origanifolia. J. Nat. Prod. 1998;61(3):338-342.
http://dx.doi.org/10.1021/np970387s