Abstract:
One new and three known sulfated steroidal polyols have been isolated from the ophiuroid Ophioplocus januarii, collected at San Antonio Oeste, Rio Negro, Argentina. The four compounds possess 4α,11β-dihydroxy-3α,21- disulfoxy substituents and the A/B cis ring junction but differ in the side chain. The new compound has been characterized as (22E)-5β-24-norcholest- 22-ene-3α,4α,11β,21-tetrol 3,21-disulfate (4). The structures of the four compounds were determined from spectral data and comparison with those of related steroidal polyols. The four compounds were tested for their inhibitory effect on the replication of one DNA and three RNA viruses. Compounds 2 and 4 were active against respiratory syncytial and polio viruses, and compound 3 inhibited Junin virus, responsible for Argentine hemorrhagic fever.
Registro:
Documento: |
Artículo
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Título: | Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii |
Autor: | Roccatagliata, A.J.; Maier, M.S.; Seldes, A.M.; Pujol, C.A.; Damonte, E.B. |
Filiación: | Depto. de Quim. Orgánica, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina Depto. de Quim. Biológica, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina
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Palabras clave: | 5beta 24 norcholest 22 ene 3alpha,4alpha,11beta,21 tetrol 3,21 disulfate; antivirus agent; natural product; steroid; unclassified drug; antiviral activity; article; drug isolation; drug structure; human; human cell; invertebrate; junin virus; nonhuman; poliomyelitis virus; respiratory syncytial pneumovirus; Animals; Anti-HIV Agents; Cell Survival; Cytopathogenic Effect, Viral; DNA Replication; DNA Viruses; RNA Viruses; Starfish; Sterols; Virus Replication; Argentina (fish); Invertebrata; Junin virus; Ophioplocus; Ophioplocus januarii; Ophiuroidea; Polio virus; Poliovirus; Respiratory syncytial virus; RNA viruses |
Año: | 1996
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Volumen: | 59
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Número: | 9
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Página de inicio: | 887
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Página de fin: | 889
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DOI: |
http://dx.doi.org/10.1021/np960171a |
Título revista: | Journal of Natural Products
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Título revista abreviado: | J. NAT. PROD.
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ISSN: | 01633864
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CODEN: | JNPRD
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CAS: | Anti-HIV Agents; Sterols
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01633864_v59_n9_p887_Roccatagliata |
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Citas:
---------- APA ----------
Roccatagliata, A.J., Maier, M.S., Seldes, A.M., Pujol, C.A. & Damonte, E.B.
(1996)
. Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii. Journal of Natural Products, 59(9), 887-889.
http://dx.doi.org/10.1021/np960171a---------- CHICAGO ----------
Roccatagliata, A.J., Maier, M.S., Seldes, A.M., Pujol, C.A., Damonte, E.B.
"Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii"
. Journal of Natural Products 59, no. 9
(1996) : 887-889.
http://dx.doi.org/10.1021/np960171a---------- MLA ----------
Roccatagliata, A.J., Maier, M.S., Seldes, A.M., Pujol, C.A., Damonte, E.B.
"Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii"
. Journal of Natural Products, vol. 59, no. 9, 1996, pp. 887-889.
http://dx.doi.org/10.1021/np960171a---------- VANCOUVER ----------
Roccatagliata, A.J., Maier, M.S., Seldes, A.M., Pujol, C.A., Damonte, E.B. Antiviral sulfated steroids from the ophiuroid Ophioplocus januarii. J. NAT. PROD. 1996;59(9):887-889.
http://dx.doi.org/10.1021/np960171a