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Abstract:

Alloimmunized lymphoid cells exert inotropic effects on isolated mouse atria. We here show that, when thymocytes were assayed on spontaneously beating isolated atria, a negative inotropic effect always appeared. When lymph node or spleen cells were assayed, they led to a biphasic effect: negative or positive inotropic effect, depending on the number of immunizations. Non-immunized lymphoid cells never exerted inotropic effects. Supernatants of alloimmunized cells cocultivated with pieces of atria from the immunizing strain exerted pharmacological effects on atria that mimicked those of whole cells. Inhibitors of lipoxygenase(s) and cyclooxygenase of arachidonic acid metabolism, inhibited the positive and negative inotropic effects, respectively. The specificity of the negative and positive inotropic effects, both in their induction and expression, was linked to the major histocompatibility complex. When T and B cells were purified from lymphoid tissues we found that they were responsible for the negative and positive inotropic effects on atria, respectively. Additionally, supernatants of T cells cultured with alloextracts triggered negative inotropic effects, but those from B cells were inactivated. © 1986.

Registro:

Documento: Artículo
Título:H-2 specific inotropic effect of alloimmune lymphoid cells on mouse isolated atria
Autor:Genaro, A.M.; Borda, E.S.; Cremaschi, G.A.; Sterin-Borda, L.; Braun, M.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET), Serrano 665/69, 1414 Buenos Aires, Argentina
Palabras clave:Alloimmunization; Arachidonic acid metabolites; Lymphocytes; Major histocompatibility complex; Myocardial activity; acetylsalicylic acid; dexamethasone; dithizone; indometacin; mepyramine; nordihydroguaiaretic acid; animal cell; b lymphocyte; cytology; drug administration; drug mechanism; heart; heart atrium; heart muscle contractility; immunization; inotropism; lymphoid cell; major histocompatibility complex; mouse; nonhuman; preliminary communication; priority journal; t lymphocyte; Animals; Atrial Function; Cells, Cultured; H-2 Antigens; Heart Atria; Immunoglobulin G; Isoantibodies; Lymph Nodes; Lymphocytes; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C57BL; Myocardial Contraction; Species Specificity; Spleen; T-Lymphocytes; Thymus Gland
Año:1986
Volumen:11
Número:3
Página de inicio:129
Página de fin:140
DOI: http://dx.doi.org/10.1016/0162-3109(86)90015-9
Título revista:Immunopharmacology
Título revista abreviado:Immunopharmacology
ISSN:01623109
CODEN:IMMUD
CAS:acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; dexamethasone, 50-02-2; dithizone, 60-10-6; indometacin, 53-86-1, 74252-25-8, 7681-54-1; mepyramine, 6036-95-9, 91-84-9; nordihydroguaiaretic acid, 500-38-9; H-2 Antigens; Immunoglobulin G; Isoantibodies
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01623109_v11_n3_p129_Genaro

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Citas:

---------- APA ----------
Genaro, A.M., Borda, E.S., Cremaschi, G.A., Sterin-Borda, L. & Braun, M. (1986) . H-2 specific inotropic effect of alloimmune lymphoid cells on mouse isolated atria. Immunopharmacology, 11(3), 129-140.
http://dx.doi.org/10.1016/0162-3109(86)90015-9
---------- CHICAGO ----------
Genaro, A.M., Borda, E.S., Cremaschi, G.A., Sterin-Borda, L., Braun, M. "H-2 specific inotropic effect of alloimmune lymphoid cells on mouse isolated atria" . Immunopharmacology 11, no. 3 (1986) : 129-140.
http://dx.doi.org/10.1016/0162-3109(86)90015-9
---------- MLA ----------
Genaro, A.M., Borda, E.S., Cremaschi, G.A., Sterin-Borda, L., Braun, M. "H-2 specific inotropic effect of alloimmune lymphoid cells on mouse isolated atria" . Immunopharmacology, vol. 11, no. 3, 1986, pp. 129-140.
http://dx.doi.org/10.1016/0162-3109(86)90015-9
---------- VANCOUVER ----------
Genaro, A.M., Borda, E.S., Cremaschi, G.A., Sterin-Borda, L., Braun, M. H-2 specific inotropic effect of alloimmune lymphoid cells on mouse isolated atria. Immunopharmacology. 1986;11(3):129-140.
http://dx.doi.org/10.1016/0162-3109(86)90015-9