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Zanichelli, P.G.; Miotto, A.M.; Estrela, H.F.G.; Soares, F.R.; Grassi-Kassisse, D.M.; Spadari-Bratfisch, R.C.; Castellano, E.E.; Roncaroli, F.; Parise, A.R.; Olabe, J.A.; De Brito, A.R.M.S.; Franco, D.W. "The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays" (2004) Journal of Inorganic Biochemistry. 98(11):1921-1932
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Abstract:

The [Ru II(Hedta)NO +] complex is a diamagnetic species crystallizing in a distorted octahedral geometry, with the Ru-N(O) length 1.756(4) Å and the RuNO angle 172.3(4)°. The complex contains one protonated carboxylate (pK a = 2.7 ± 0.1). The [Ru II(Hedta)NO +] complex undergoes a nitrosyl-centered one-electron reduction (chemical or electrochemical), with E NO+/NO = -0.31 V vs SCE (I = 0.2 M, pH 1), yielding [Ru II(Hedta)NO] -, which aquates slowly: k -NO = 2.1 ± 0.4 × 10 -3 s -1 (pH 1.0, I = 0.2 M, CF 3COOH/NaCF 3COO, 25°C). At pHs > 12, the predominant species, [Ru II(edta)NO] -, reacts according to [Ru II(edta) NO] - + 2OH - ⇒ [Ru II(edta)NO 2] 3-, with K eq = 1.0 ± 0.4 × 10 3 M -2 (I = 1.0 M, NaCl; T = 25.0 ± 0.1°C). The rate-law is first order in each of the reactants for most reaction conditions, with k OH - = 4.35 ± 0.02 M -1 s -1 (25.0°C), assignable mechanistically to the elementary step comprising the attack of one OH - on [Ru II(edta)NO] -, with subsequent fast deprotonation of the [Ru II(edta) NO 2H] 2- intermediate. The activation parameters were ΔH # = 60 ± 1 kJ/mol, ΔS # = -31 ± 3 J/K mol, consistent with a nucleophilic addition process between likely charged ions. In the toxicity up-and-down tests performed with Swiss mice, no death was observed in all the doses administered (3-9.08 × 10 -5 mol/kg). The biodistribution tests performed with Wistar male rats showed metal in the liver, kidney, urine and plasma. Eight hours after the injection no metal was detected in the samples. The vasodilator effect of [Ru II(edta)NO] - was studied in aortic rings without endothelium, and was compared with sodium nitroprusside (SNP). The times of maximal effects of [Ru II(edta)NO] - and SNP were 2 h and 12 min, respectively, suggesting that [Ru II(edta)NO] - releases NO slowly to the medium in comparison with SNP. © 2004 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays
Autor:Zanichelli, P.G.; Miotto, A.M.; Estrela, H.F.G.; Soares, F.R.; Grassi-Kassisse, D.M.; Spadari-Bratfisch, R.C.; Castellano, E.E.; Roncaroli, F.; Parise, A.R.; Olabe, J.A.; De Brito, A.R.M.S.; Franco, D.W.
Filiación:Inst. de Quím. de S. Carlos, Univ. S. Paulo - Av. Trabalhador S., CEP: 13560-970 - S. Carlos - SP, B., Brazil
Depto. de Fisiol. e Biofísica, Instituto de Biologia, Univ. Estadual Campinas - C., Brazil
Inst. de Fís. de S. Carlos, Universidade de São Paulo, 135 - Av. Trabalhador S. C., Brazil
Depto. de Quím. Inorg., Analitica Y Quim. Fis., INQUIMAE, Fac. Cie. Exact. Y N., Argentina
Palabras clave:Nitrosyl reactivity; NO-donors; Nucleophilic reactivity; Ruthenium nitrosyl; Vasodilator activity; carboxylic acid; hydroxide; metal; nitric oxide; nitroprusside sodium; ruthenium derivative; addition reaction; animal experiment; article; bioaccumulation; bioassay; chemical reaction; controlled study; crystallization; death; drug effect; drug structure; electricity; electrochemistry; electron; endothelium; geometry; injection; kidney; liver; male; nonhuman; parameter; plasma; proton transport; rat; reaction analysis; reduction; sample; structure analysis; time; toxicity; urine; vascular ring; vasodilatation; Animals; Crystallography, X-Ray; Edetic Acid; Electrochemistry; Male; Mice; Models, Molecular; Molecular Conformation; Nitric Oxide; Ruthenium; Tissue Distribution; Xenox
Año:2004
Volumen:98
Número:11
Página de inicio:1921
Página de fin:1932
DOI: http://dx.doi.org/10.1016/j.jinorgbio.2004.08.020
Título revista:Journal of Inorganic Biochemistry
Título revista abreviado:J. Inorg. Biochem.
ISSN:01620134
CODEN:JIBID
CAS:hydroxide, 14280-30-9; nitric oxide, 10102-43-9; nitroprusside sodium, 14402-89-2, 15078-28-1; Edetic Acid, 60-00-4; N-(hydroxyethyl)ethylenediaminetriacetic acid, 150-39-0; Nitric Oxide, 10102-43-9; Ruthenium, 7440-18-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01620134_v98_n11_p1921_Zanichelli

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Citas:

---------- APA ----------
Zanichelli, P.G., Miotto, A.M., Estrela, H.F.G., Soares, F.R., Grassi-Kassisse, D.M., Spadari-Bratfisch, R.C., Castellano, E.E.,..., Franco, D.W. (2004) . The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays. Journal of Inorganic Biochemistry, 98(11), 1921-1932.
http://dx.doi.org/10.1016/j.jinorgbio.2004.08.020
---------- CHICAGO ----------
Zanichelli, P.G., Miotto, A.M., Estrela, H.F.G., Soares, F.R., Grassi-Kassisse, D.M., Spadari-Bratfisch, R.C., et al. "The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays" . Journal of Inorganic Biochemistry 98, no. 11 (2004) : 1921-1932.
http://dx.doi.org/10.1016/j.jinorgbio.2004.08.020
---------- MLA ----------
Zanichelli, P.G., Miotto, A.M., Estrela, H.F.G., Soares, F.R., Grassi-Kassisse, D.M., Spadari-Bratfisch, R.C., et al. "The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays" . Journal of Inorganic Biochemistry, vol. 98, no. 11, 2004, pp. 1921-1932.
http://dx.doi.org/10.1016/j.jinorgbio.2004.08.020
---------- VANCOUVER ----------
Zanichelli, P.G., Miotto, A.M., Estrela, H.F.G., Soares, F.R., Grassi-Kassisse, D.M., Spadari-Bratfisch, R.C., et al. The [Ru(Hedta)NO] 0,1- system: Structure, chemical reactivity and biological assays. J. Inorg. Biochem. 2004;98(11):1921-1932.
http://dx.doi.org/10.1016/j.jinorgbio.2004.08.020