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Abstract:

The selectivity of MnIII/II porphyrinates toward nitroxyl or nitric oxide donors provides a convenient starting point for the development of new materials for the speciation of these nitrogen-containing redox relatives. In the present report, we describe the insertion of MnIII protoporphyrinate IX in apomyoglobin and its chemical behavior toward HNO or NO donors, either under anaerobic or aerobic conditions. For comparison and discussion, the MnIII porphyrinate, devoid of the protein matrix, was studied in parallel. The MnIII reconstituted globin successfully reacted with the nitroxyl donor trioxodinitrate, while it was unreactive toward NO or NO donors, in good agreement with previously reported data on water soluble MnIII porphyrinates. The estimated association rate constant for the reaction with the nitroxyl donor was of the same order of magnitude for the reconstituted globin and the free porphyrinate, suggesting that the protein environment is not involved in the reaction mechanism. In contrast, the reaction product exhibited enhanced stability in the presence of dioxygen only when the porphyrinate was included in the protein matrix; this feature is ascribed to the role of the distal residues on the metal centered reactivity. This behavior is required for spectroscopic detection under biologically relevant conditions. © 2011 Elsevier Inc.

Registro:

Documento: Artículo
Título:A protective protein matrix improves the discrimination of nitroxyl from nitric oxide by MnIII protoporphyrinate IX in aerobic media
Autor:Boron, I.; Suárez, S.A.; Doctorovich, F.; Martí, M.A.; Bari, S.E.
Filiación:Departamento de Química Inorgánica, Analítica y Química Física, Ciudad Universitaria, Pab. II, Buenos Aires (C1428EHA), Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pab. II, Buenos Aires (C1428EHA), Argentina
Palabras clave:Nitric oxide; Nitroxyl; Reconstituted apomyoglobin; Speciation; apomyoglobin; manganese; nitric acid derivative; nitric oxide; aerobic capacity; anaerobic capacity; article; chemical reaction; chemical reaction kinetics; controlled study; culture medium; decomposition; molecular mechanics; spectral sensitivity; spectroscopy
Año:2011
Volumen:105
Número:8
Página de inicio:1044
Página de fin:1049
DOI: http://dx.doi.org/10.1016/j.jinorgbio.2011.05.002
Título revista:Journal of Inorganic Biochemistry
Título revista abreviado:J. Inorg. Biochem.
ISSN:01620134
CODEN:JIBID
CAS:manganese, 16397-91-4, 7439-96-5; nitric oxide, 10102-43-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01620134_v105_n8_p1044_Boron

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Citas:

---------- APA ----------
Boron, I., Suárez, S.A., Doctorovich, F., Martí, M.A. & Bari, S.E. (2011) . A protective protein matrix improves the discrimination of nitroxyl from nitric oxide by MnIII protoporphyrinate IX in aerobic media. Journal of Inorganic Biochemistry, 105(8), 1044-1049.
http://dx.doi.org/10.1016/j.jinorgbio.2011.05.002
---------- CHICAGO ----------
Boron, I., Suárez, S.A., Doctorovich, F., Martí, M.A., Bari, S.E. "A protective protein matrix improves the discrimination of nitroxyl from nitric oxide by MnIII protoporphyrinate IX in aerobic media" . Journal of Inorganic Biochemistry 105, no. 8 (2011) : 1044-1049.
http://dx.doi.org/10.1016/j.jinorgbio.2011.05.002
---------- MLA ----------
Boron, I., Suárez, S.A., Doctorovich, F., Martí, M.A., Bari, S.E. "A protective protein matrix improves the discrimination of nitroxyl from nitric oxide by MnIII protoporphyrinate IX in aerobic media" . Journal of Inorganic Biochemistry, vol. 105, no. 8, 2011, pp. 1044-1049.
http://dx.doi.org/10.1016/j.jinorgbio.2011.05.002
---------- VANCOUVER ----------
Boron, I., Suárez, S.A., Doctorovich, F., Martí, M.A., Bari, S.E. A protective protein matrix improves the discrimination of nitroxyl from nitric oxide by MnIII protoporphyrinate IX in aerobic media. J. Inorg. Biochem. 2011;105(8):1044-1049.
http://dx.doi.org/10.1016/j.jinorgbio.2011.05.002