Artículo
Filevich, O.; Salierno, M.; Etchenique, R. "A caged nicotine with nanosecond range kinetics and visible light sensitivity" (2010) Journal of Inorganic Biochemistry. 104(12):1248-1251
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Abstract:
We report the synthesis, characterization and applications of a ruthenium-bipyridine based caged nicotine. The complex [Ru(bpy)2(nic)2]2+ (where bpy=2,2' bipyridine and nic=nicotine (3-[(2S)-1-methylpyrrolidin-2-yl] pyridine)) releases nicotine with a quantum yield Φ=0.23 upon irradiation with biologically harmless, blue (473nm) or green (532nm) light. The photolysis reaction is clean and very fast, with a time constant of 17ns. The synthesis is simple and the obtained compound is characterized by NMR, UV-Vis spectroscopy and cyclic voltametry. We find that this compound is active in biological systems, being able to elicit action potentials in leech neurons. © 2010 Elsevier Inc.
Registro:
| Documento: | Artículo |
| Título: | A caged nicotine with nanosecond range kinetics and visible light sensitivity |
| Autor: | Filevich, O.; Salierno, M.; Etchenique, R. |
| Filiación: | Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2 Piso 3, C1428EHA, Buenos Aires, Argentina |
| Palabras clave: | Caged compound; Leech; NAChR; Neurotransmitter; Nicotine; Ruthenium complex; bipyridine; caged nicotine; nicotine; ruthenium; unclassified drug; article; complex formation; controlled study; cyclic potentiometry; irradiation; kinetics; leech; nonhuman; nuclear magnetic resonance spectroscopy; photolysis; quantum yield; synthesis; ultraviolet spectroscopy; Animals; Electrophysiology; Leeches; Light; Magnetic Resonance Spectroscopy; Models, Chemical; Neurons; Nicotine; Photochemistry; Photolysis; Ruthenium; Hirudinida |
| Año: | 2010 |
| Volumen: | 104 |
| Número: | 12 |
| Página de inicio: | 1248 |
| Página de fin: | 1251 |
| DOI: | http://dx.doi.org/10.1016/j.jinorgbio.2010.08.003 |
| Título revista: | Journal of Inorganic Biochemistry |
| Título revista abreviado: | J. Inorg. Biochem. |
| ISSN: | 01620134 |
| CODEN: | JIBID |
| CAS: | bipyridine, 37275-48-2; nicotine, 54-11-5; ruthenium, 7440-18-8; Nicotine, 54-11-5; Ruthenium, 7440-18-8 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01620134_v104_n12_p1248_Filevich |
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Citas:
---------- APA ----------
Filevich, O., Salierno, M. & Etchenique, R. (2010) . A caged nicotine with nanosecond range kinetics and visible light sensitivity. Journal of Inorganic Biochemistry, 104(12), 1248-1251.http://dx.doi.org/10.1016/j.jinorgbio.2010.08.003
---------- CHICAGO ----------
Filevich, O., Salierno, M., Etchenique, R. "A caged nicotine with nanosecond range kinetics and visible light sensitivity" . Journal of Inorganic Biochemistry 104, no. 12 (2010) : 1248-1251.http://dx.doi.org/10.1016/j.jinorgbio.2010.08.003
---------- MLA ----------
Filevich, O., Salierno, M., Etchenique, R. "A caged nicotine with nanosecond range kinetics and visible light sensitivity" . Journal of Inorganic Biochemistry, vol. 104, no. 12, 2010, pp. 1248-1251.http://dx.doi.org/10.1016/j.jinorgbio.2010.08.003
---------- VANCOUVER ----------
Filevich, O., Salierno, M., Etchenique, R. A caged nicotine with nanosecond range kinetics and visible light sensitivity. J. Inorg. Biochem. 2010;104(12):1248-1251.http://dx.doi.org/10.1016/j.jinorgbio.2010.08.003
