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Abstract:

The contractile activity of uterine horns maintained for 90 to 120 minutes under normal oxygenation (carbogen or 100% O2) became undetectable. When in this condition the gassing was stopped one or two minutes later, regular phasic contractions appeared super-imposed on a small increment of the basal resting tone. Indomethacin and aspirin well known inhibitors of prostaglandin (PG) synthesis, blocked the contractile influence of hypoxia whereas neither tranylcypromine or imidazole were able to alter the stimulatery action. PGE2, PGE1 and PGF2α released into the bathing solution during 10 minutes of normoxia or 10 minutes of hypoxia, were measured. Under O2, PGE2 and PGF2α production diminished significantly (P < 0.05 and P < 0.01, normoxia vs. hypoxia, respectively) whereas PGE1 increased (P < 0.05). "PGI2-like material" generated was also detected and it was found that the values during hypoxia were lower than those observed in 02; however the difference was not statistically significant. Dose-response contractile activity to PGs with and without gassing was explored. It was necessary to add 100 times more PGF2α to obtain the minimal response under hypoxic conditions as compared to normoxia. On the other hand the threshold response to PGE1 was 10 times lower under hypoxic conditions than in normoxia. The possible mechsnism(s) that induce an increment in PGE1 generation accompanied by a simultaneous decrement of PGE2 during hypoxia is discussed in connection with a possible role of PGE1 evoking uterine contractions when the gassing of the suspending solution is stopped. © 1981.

Registro:

Documento: Artículo
Título:Does hypoxia selectively stimulate the generation of prostaglandin E1 by the isolated rat uterus?
Autor:Gimeno, M.F.; Chaud, M.; Borda, E.S.; Lazzari, M.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Natureles (CEFAPRIN), V. de Obligedo 2490, 1428 Buenos Aires, Argentina
Consejo Necional de Investigeciones Cientificas y Técnicas (CONICET), V. de Obligedo 2490, 1428 Buenos Aires, Argentina
Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Argentina Technical assistance of A.M.Fuentes and S.Lugo is gratefully acknowledged, Pacheco de Melo 3081, 1425 Buenos Aires
Palabras clave:acetylsalicylic acid; imidazole; indometacin; prostacyclin; prostaglandin e1; prostaglandin e2; prostaglandin f2 alpha; radioisotope; tranylcypromine; animal experiment; dose response; drug response; female genital system; hypoxia; in vitro study; radioimmunoassay; rat; uterus contractility; uterus contraction; Alprostadil; Animals; Anoxia; Dinoprost; Dinoprostone; Female; Oxygen; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Uterine Contraction; Uterus
Año:1981
Volumen:7
Número:5
Página de inicio:375
Página de fin:388
DOI: http://dx.doi.org/10.1016/0161-4630(81)90026-4
Título revista:Prostaglandines and Medicine
ISSN:01614630
CAS:acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; imidazole, 1467-16-9, 288-32-4; indometacin, 53-86-1, 74252-25-8, 7681-54-1; prostacyclin, 35121-78-9, 61849-14-7; prostaglandin E1, 745-65-3; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; tranylcypromine, 13492-01-8, 155-09-9, 54-97-7; Alprostadil, 745-65-3; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Oxygen, 7782-44-7; Prostaglandins E; Prostaglandins F
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01614630_v7_n5_p375_Gimeno

Referencias:

  • Alexander, Kent, Pisano, Keiser, Cooper, Regulation of postoclusive hyperemnia by endogenously synthesized prostaglandins in the dog heart (1975) Journal of Clinical Investigation, 35, p. 1174
  • Block, Feinderg, Herbaczynska-Cedro, Vane, Anoxia induced release of prostaglandin in rabbit isolated hearts (1975) Circulation Res., 36, p. 34
  • Wennmalm, Pham-Huu-Chanh, Justand, Hypoxia causes prostaglandin release from perfused rabbit hearts (1974) Acta Physiol. Scand., 91, p. 133
  • Needleman, Ke, Isakson, Kulkarni, Relationship between oxygen tension, coronary vasodilatation and prostaglandin biosynthesis in the isolated rabbit heart (1975) Prostaglandins, 9, p. 123
  • Jaffe, Parker, Marshall, Needleman, Renal concentrations of prostaglandin E in acute and chronic renal ischemia (1972) Biochem. Biophys. Res. Comm., 49, p. 799
  • Said, Yoshida, Kitamura, Vreim, Pulmonary alveolar hypoxia release of Prostaglandins and other humoral mediators (1974) Science, 185, p. 1181
  • Clyman, Mauray, Demers, Rudolph, Roman, Does oxygen regulate prostaglandin-induced relaxation in the lamb ductus arteriosus? (1980) Prostaglandin, 19, p. 489
  • Zenser, Levitt, Davis, Possible modulation of renal prostaglandins by oxygen (1977) Prostaglandins, 13, p. 143
  • Flower, Blackwell, The importance of phospholipase A2 in prostaglandin biosynthesis (1976) Biochem. Pharmacol., 25, p. 285
  • Lands, Samuelsson, Phospholipid precursors of prostaglandins (1968) Biochim. Biophys. Acta, 164, p. 426
  • Haye, Champion, Jacqueim, Control by TSH of a phospholipase A2 activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid (1973) FEBS LETT., 30, p. 253
  • Nugteren, Van Dorp, The participation of molecular oxygen in the biosynthesis of prostaglandins (1975) Biochem. Biophys. Acta, 98, p. 652
  • Hsueh, Isakson, Needlemen, Hormone relective lipase activation in the isolated rabbit heart (1977) Prostaglandins, 13, p. 1073
  • Markelonis, Garbus, Elaboration of medium chain free fatty acids and long chain fatty acid prostaglandin precursors by isolated anoxic rat liver mitochondria (1975) FEBS LETT., 51, p. 7
  • Ventura, Freun, Influence of P02 on the motility of the rat female reproductive tract, in vitro and its response to oxytocin (1971) Eur. J. Pharmacol., 14, p. 257
  • Lima, Gimeno, Goldraij, Gimeno, Prostaglandin F2α and motility of the myometrium isolated from ovariectomized rats. Effects of 17β estradiol (1971) Life Sci., 10, p. 999
  • Borda, Sauvage, Sterin-Borda, Gimeno, Gimeno, Adrenoceptors involved in the contractile activity of isolated pegnent rat uterus (1979) European Journal of Pharmacology, 56, p. 61
  • Gimeno, Sterin-Speziele, Landa, Bonacossa, Gimeno, Is the spontaneous motility of isolated rat uterus controled by prostaglandin E? (1979) Prostaglandins, 17, p. 673
  • Sterin-Speziale, Gimeno, Bonacossa, Gimeno, The effect of estradiol on isolated rat uterine motility and on prostaglandin generation (1980) Prostaglandins, 20, p. 233
  • Gimeno, Borda, Lazzari, Gimeno, Ovarian hormones inhibit the release of prostacyclin-like material from isolated rat uterus (1980) Prostaglandins, 20, p. 223
  • Maclouf, Andrieu, Dray, Validity of PGE1 radioimmunoassay by using PGE1 antisera with differential binding parameters (1975) FEBS LETT., 56, p. 273
  • Pipili, Poyser, Effects of nerve stimulation and of administration of noradrenaline or potassium chloride upon the release of prostaglandins I2, E2 and F2α from perfused mesenteric arterial bed of the rabbit (1981) Br. J. Pharmac., 72, p. 89
  • Gimeno, Borda, Lazzari, Gimeno, Ovarian hormones inhibit the release of prostacyclin-like material from isolated rat uterus (1980) Prostaglandins, 20, p. 223
  • Gryglewsky, Bunting, Moncada, Flower, Vane, Arterial walls are protected against deposition of platelet thrombi by a substance (Prostaglandin X) which they make from prostaglandin endoperoxidese (1976) Prostaglandins, 12, p. 685
  • Moncada, Bunting, Mullene, ThoroGood, Vane, Imidazol: a selective inhibitor of thrombaxone synthetase (1977) Prostaglandins, 13, p. 611
  • Williams, Dembinske-Kiec, Zmuda, Gryglewski, Prostacyclin formation by myometrial and decidual fractions of the pregnant rat uterus (1978) Prostaglandins, 15, p. 343
  • Polacek, Daniel, Accumulation of adenosine 3′5 monophosphate and relaxation of the rat uterus in vitro (1971) Can. J. Physiol. Pharmecol., 49, p. 999
  • Kalsner, The effect of hypoxia on prostaglandin output and on the tone in isolated coronary arteries (1977) Can. J. Physiol. Pharmacal., 55, p. 882
  • Van Dorp, Becrthuis, Nugteren, Von Kerman, Enzymatic conversion of all-cispolyunsatured fatty acids into prostaglandins (1964) Nature, 203, p. 839
  • Leaver, Poyser, Distribution of arachidonic acid and other fatty acids in the lipids of guinea-pig uterus and plasma in relation to uterine prostaglandin synthesis (1981) J. Reprod. Fert., 61, p. 325
  • Manku, Horrobin, Karmazyn, Cunnane, Prolactin and zinc effects on rat vascular reactivity: possible relationship to dihomogamma malinolenic acid and to prostaglandin synthesis (1979) Endocrinology, 104, p. 774
  • Horrobin, Oka, Manku, The regulation of prostaglandin E1 formation: a candidate for one of the fundamental mechanisms involved in the actions of vitamin C (1979) Medical Hypotheses, 5, p. 849
  • Manku, Oka, Horrobin, Differential regulation of the formation of prosteglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. I. Effects of ethanol (1979) Prostaglandins Med., 3, p. 119
  • Feinstein, Becker, Fraser, Thrombin, collagen and A23187 stimulate platelet arachidonate metabolism: differential inhibition by PGE1, local anesthetic and a serine-protease inhibitor (1977) Prostaglandins, 14, p. 1075
  • Strong, Bohr, Effects of prostaglandins E1, E2, A1 and F1α an isolated vascular smooth muscle (1967) Am. J. Physiol., 213, p. 725
  • Kadotiitz, Joiner, Hymen, George, Influence of PGE1 and F2α on pulmonary vascular resistance isolated lobar vessels and cyclic nucleotide levels (1975) J. Pharmacol. Exp. Ther., 192, p. 677
  • Beatty, Bocek, Prostaglandins: their effects on the carbohydrate metabolism of myometrium from Rhesus Monkeys (1972) Endocrinology, 90, p. 1295
  • Willebrands, Tasseron, Effects of hormones on sustrate preference in isolated rat heart (1968) Am.J. Physiol., 215, p. 1089

Citas:

---------- APA ----------
Gimeno, M.F., Chaud, M., Borda, E.S., Lazzari, M. & Gimeno, A.L. (1981) . Does hypoxia selectively stimulate the generation of prostaglandin E1 by the isolated rat uterus?. Prostaglandines and Medicine, 7(5), 375-388.
http://dx.doi.org/10.1016/0161-4630(81)90026-4
---------- CHICAGO ----------
Gimeno, M.F., Chaud, M., Borda, E.S., Lazzari, M., Gimeno, A.L. "Does hypoxia selectively stimulate the generation of prostaglandin E1 by the isolated rat uterus?" . Prostaglandines and Medicine 7, no. 5 (1981) : 375-388.
http://dx.doi.org/10.1016/0161-4630(81)90026-4
---------- MLA ----------
Gimeno, M.F., Chaud, M., Borda, E.S., Lazzari, M., Gimeno, A.L. "Does hypoxia selectively stimulate the generation of prostaglandin E1 by the isolated rat uterus?" . Prostaglandines and Medicine, vol. 7, no. 5, 1981, pp. 375-388.
http://dx.doi.org/10.1016/0161-4630(81)90026-4
---------- VANCOUVER ----------
Gimeno, M.F., Chaud, M., Borda, E.S., Lazzari, M., Gimeno, A.L. Does hypoxia selectively stimulate the generation of prostaglandin E1 by the isolated rat uterus?. 1981;7(5):375-388.
http://dx.doi.org/10.1016/0161-4630(81)90026-4